DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and Myo61F

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	914	Identity:	247/914 - (27%)
Similarity:	395/914 - (43%)	Gaps:	196/914 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 SQQKMQ----QQQQQGNSSPKDMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPY 517
            ||.||:    ::.:.|      :||.:.|....:|.|.:..|:.||.|...:|.:|.:|:|:|||
  Fly    23 SQLKMETGLHERDRAG------VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPY 81

  Fly   518 LDVGNPL-TLTSTRA--------MPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAM 573
            ..:  |: |....:|        ||  |.:..:...|.|...|....|.:::||.||:|||..:.
  Fly    82 KQL--PIYTDDHVKAYRNKHFYEMP--PHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASK 142

  Fly   574 LMLRQLFAIAGGGPETDAFK-HLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVT-DGALYRTK 636
            .:|:.:.|.:|.....:..| .|..:..||.:.|:|||..|..|||.|:::::|.. .||.....
  Fly   143 KVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGN 207

  Fly   637 IHCYFLDQTRVIRPLPKEKNYHIFYQLLAG----LSREERQKLHLDGYSPANLRYLRGDIG--QN 695
            |..|.|:::||:..:..|:|:|||||||||    |.:|.|.:..||.||     ||...:.  ..
  Fly   208 ILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYS-----YLTDGLNGTVT 267

  Fly   696 EQEDAARFQAWKTCLGILGIPFL-----DVVRVLAAVLLLGNVQFIDGGGLEVDVKGETELNS-- 753
            ...||..|:..:..|.:  |.|.     ::..::|::|.||||.|       .:|:|..::||
  Fly   268 RINDADSFKQVQQALTV--IDFTKEEQREIFGIVASILHLGNVGF-------TEVEGNAKVNSRD 323

  Fly   754 ----VASLLGVPPAALFRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRAN 814
                .|.||||..:.|...||.||.:.||.:|.|......|...||.||||:|.|..:.:|:|.|
  Fly   324 LVVTAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLN 388

  Fly   815 SLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDM 879
                       :|..:.|                        :.|:.||.         :||||:
  Fly   389 -----------ISLQAKE------------------------TRASRNNV---------MGILDI 409

  Fly   880 FGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISS 944
            :|||....:: .|..|||.|.|.:|..:.....||..:..|.|||.. ..|:|.||....:||..
  Fly   410 YGFEIFQKNS-FEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEW-IPVEYFDNKVICNLIEE 472

  Fly   945 LRTGLLSMLDAECSVRG--TAESYVTKLK---VQHRSSTRLETKPTAEPHDPRM-----FLIRHF 999
            ...|::|:||.||...|  |.::::.||.   .||......|..|.   |..::     |.:.|:
  Fly   473 KHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPA---HIKKIMLRDEFRLVHY 534

  Fly  1000 AGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPT 1064
            ||.|.|....|||.|.|::..||     |.|.:                   :|..|:.....|
  Fly   535 AGEVTYSVNGFLDKNNDLLFRDL-----KETLS-------------------KAGNGIVRNCFP- 574

  Fly  1065 SHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQ 1129
             ..:|.:...|.:.:|| |...|:||:..|:...|.::|||:.|..:.|..|:...|:.|::.|.
  Fly   575 -EKELRSLKRPETAITQ-FRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLG 637

  Fly  1130 VLETVNLMASGFPHRMRFKQFNARYRMLA------------PFRLLRRSEDKALEDCQLILKYAM 1182
            ::|.:.:..:||.:|..::.|..||:.|:            |    :....:.::|    |.:..
  Fly   638 LMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGP----KAGVQQLVKD----LGWDE 694

  Fly  1183 EQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGW------------ 1235
            |:..|.:..:.:.|   .|.:|.:|...|       |.:|:.|.::||.|:|.
  Fly   695 EKYRVGETKLFIRW---PRTLFDTEDAYQ-------EKKHEIAAIIQAHWKGLMQRRKYLKLRAQ 749

  Fly  1236 ------WWRKKMGNGGAKR-----SKIPGLQQAPLPNNKTTPNSAAQNKAASSTMAALAAVAAAA 1289
                  :.|:|:....||:     .||....:..:..| ..||...:...|::....|..:|...
  Fly   750 VIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRN-DAPNGFNEEFIANAKRMWLLRLAKEL 813

  Fly  1290 PISV 1293
            |..|
  Fly   814 PTKV 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	221/790 (28%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	215/767 (28%)
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	221/798 (28%)
		MYSc_Myo1	52..707	CDD:276829	212/756 (28%)
		Myosin_TH1	863..1035	CDD:283635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466238
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940