DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and zip

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster

Alignment Length:	896	Identity:	219/896 - (24%)
Similarity:	355/896 - (39%)	Gaps:	215/896 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 QKMQQQQQQGNSSPK--DMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVG 521
            |||        :.||  .::|:..|: .|.|.:|:..::.|:.....:|..|...:.:|||
  Fly   123 QKM--------NPPKFDKVEDMAELT-CLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPY---- 174

  Fly   522 NPLTLTSTRAM---------PLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLR 577
            ..|.:.:.:.|         .:.|.:..|...|.|........|:|:.:|.||||||.|...:::
  Fly   175 KKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQ 239

  Fly   578 QLFAIAGGGP----------------------------------------------------ETD 590
            .|..:|...|                                                    |.:
  Fly   240 FLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGE 304

  Fly   591 AFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQV-TDGALYRTKIHCYFLDQTRVIRPLPKE 654
            ..:.|..|..:|.:.|:|||..|..|||.|:||.:.. ..|.:....|..|.|:::|.||....|
  Fly   305 LEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDE 369

  Fly   655 KNYHIFYQLLAGLSREERQKLHLDGYSPANLRYL-RGDIGQNEQEDAARFQAWKTCLGILGI--- 715
            :.:|||||||||.:.|:|:|..||...  :..:| .|.:.....:|.|.|||....:.|:|:
  Fly   370 RTFHIFYQLLAGATPEQREKFILDDVK--SYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSE 432

  Fly   716 PFLDVVRVLAAVLLLGNVQF-IDGGGLEVDVKGETELNSVASLLGVPPAALFRGLTTRTHNVRGQ 779
            .|..:.|:::||||.|:::| .:....:..:...|....:|.|||:....:.|...|....|...
  Fly   433 DFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRD 497

  Fly   780 LVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQH 844
            .|.............:.:|||.|.|....:|.|.|
  Fly   498 FVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRIN------------------------------ 532

  Fly   845 ASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNT 909
                          .:|:...|...|  |||||||.|||....:: .|.||||...|.:|..:|.
  Fly   533 --------------RSLDRTKRQGAS--FIGILDMAGFEIFELNS-FEQLCINYTNEKLQQLFNH 580

  Fly   910 HIFKSSVESCRDEGIVCDTEVDY-VDNVPCIDLISSLRTGLLSMLDAEC-SVRGTAESYVTKL-- 970
            .:|....|..:.|||.... :|: :|..|.||||.. ..|::::||.|| ..:.|.:::|.||
  Fly   581 TMFILEQEEYQREGIEWKF-IDFGLDLQPTIDLIDK-PGGIMALLDEECWFPKATDKTFVDKLVS 643

  Fly   971 -KVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFY----KHT 1030
             ...|....:.:.:..|:      |.|.|:||||:|....:|..|.|.:.:::|.:..    ...
  Fly   644 AHSMHPKFMKTDFRGVAD------FAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFV 702

  Fly  1031 CNFGFATHLFGSELKALYAQQ---QAPRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLR 1092
            .|......:.|...:||...|   :..:|: ||                 |::..:..:|..|:.
  Fly   703 VNIWKDAEIVGMAQQALTDTQFGARTRKGM-FR-----------------TVSHLYKEQLAKLMD 749

  Fly  1093 TLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRML 1157
            ||.:..|:|||||..|..:.|...|...|:.|:|...|||.:.:...|||:|:.|::|..||.:|
  Fly   750 TLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELL 814

  Fly  1158 APFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEH------- 1215
            .| .::.:......:.|:.::: |:|    ||.::   :..|:..:|...|:..|||.
  Fly   815 TP-NVIPKGFMDGKKACEKMIQ-ALE----LDSNL---YRVGQSKIFFRAGVLAHLEEERDFKIS 870

  Fly  1216 ----------------------------LRTEIRHKSATLMQATWRGWWWR 1238
                                        :|...|:.:|.|....|:  |||
  Fly   871 DLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQ--WWR 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	206/854 (24%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	198/796 (25%)
zip	NP_523860.2	Myosin_N	80..117	CDD:280832
		Myosin_head	133..854	CDD:278492	202/809 (25%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	198/796 (25%)
		Myosin_tail_1	931..2011	CDD:279860
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930