Protein Alignment dachs and Myo10A

DIOPT Version :10

• Sequence 1: NP_001188730.1
• Gene: dachs / 34179
• FlyBaseID: FBgn0262029
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Alignment Length: 1035
• Identity: 292/1035 - (28%)
• Similarity: 436/1035 - (42%)
• Gaps: 209/1035 - (20%)

  Fly   421 HLSHAHSQQLPFIPQSK-HTNPC---QSVKTL-----------PFGFGFSESQQKMQQQQQQGNS 470
            :||..|    |.:|.|: ....|   |.||.|           |..|.....:..::.:|..|:|
  Fly    95 NLSAKH----PALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSS 155

  Fly   471 SPKDMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPY--------LDV-----GN 522
            ..:||.    |...|.|.:::..|:.|:::...:|..|.||:::|||        |:|     |.
  Fly   156 GVEDMT----LLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGR 216

  Fly   523 PLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGP 587
            ||.       .|.|.|..|...|   .:....||.:::||.||:|||.:..|:::.|.|:..||.
  Fly   217 PLG-------SLPPHLFAIGAAA---HAALPSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGG 271

  Fly   588 ETDAF--KHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTDGALYRTKIHCYFLDQTRVIRP 650
            ...|.  :.:..|..:|.:.|:|:|..|..|||.|:::||....||:...||..|.|:::|::..
  Fly   272 SASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVGAKITQYLLEKSRIVTQ 336

  Fly   651 LPKEKNYHIFYQLLAGLSREERQK---LHLDGYSPANLRYLRGDIGQNEQEDAARFQAWKTCLG- 711
            .|.|:|||:||:||.|||..||.|   |..|.|...|         |...:.|:....|::..|
  Fly   337 APGERNYHVFYELLGGLSETERSKYGLLEADKYFYLN---------QGATDCASGRVDWESLQGA 392

  Fly   712 --ILGIPFLD---VVRVLAAVLLLGNVQF----IDGGGLEVDVKGETELNSVASLLGVPPAALFR 767
              :||:...:   :||||||||.||||.|    :..|...|:|..:.|:...|.||.:....|.|
  Fly   393 MQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHR 457

  Fly   768 GLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNE 832
            .||:||...|.:.:.:..|...|...||..|||||......:|.|.||:.:.|.|
  Fly   458 ALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGT---------- 512

  Fly   833 SVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCIN 897
                                         ::|.|       |.|||:||||:.:.:: .|.||||
  Fly   513 -----------------------------HDAHR-------ISILDIFGFEDLAENS-FEQLCIN 540

  Fly   898 LCAETMQHFYNTHIFK-SSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-R 960
            ...|.:|.::|.|:|| ...|..|:.  :..|.:.:.||:|.|.|::....|:..:||.|.:. |
  Fly   541 YANENLQLYFNKHVFKLEQAEYARER--LEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPR 603

  Fly   961 GTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGV 1025
            .|..|::.|....|..| .|..:|.....:   |.:.|:||:|.|....|||.|||.:..|::.:
  Fly   604 ATDLSFLEKCHYNHALS-ELYARPRIGAQE---FGVTHYAGQVWYCVDGFLDKNRDALRGDVLEL 664

  Fly  1026 FYKHTCNFGFATHLFGSELKALYAQQQA----PRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTR 1086
            ....      ...|.|...|.|.||:.|    |:|        |:...:.......|:...|...
  Fly   665 LASS------RLPLVGELTKQLRAQRDAGKTLPKG--------SNGRFVTMKPRTPTVAARFADS 715

  Fly  1087 LDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFN 1151
            |..||:::....|.|||||:.|..:.|...|...|::|:|.|.:|:|:.:...|:|.|:||:.|.
  Fly   716 LQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFV 780

  Fly  1152 ARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHL 1216
            .|||.|.|..|.|.:..:.|  |:.:|: ||.:..|......|    |...|||.|.:.:.||..
  Fly   781 ERYRHLLPSPLARGTPYREL--CRALLE-AMPRTGVEGPDYQL----GATRVFLREALHRALESG 838

  Fly  1217 RTE-----------------------IRHKSATLMQATWRGW-----WWRKKMG--------NGG 1245
            |||                       .|..:||.:||.|||.     :.|.:.|        .|.
  Fly   839 RTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGR 903

  Fly  1246 AKRSKIPGLQQAPLPNNKTTPNSAAQNKAASSTMAALAAVAAAAPISVPRLSAKTTSL------- 1303
            ..|.::..|:..  ...:.....|||.  |.....|..||...:.:|...:.|:...:
  Fly   904 QARRRVQQLRSD--HRRRQEAREAAQR--AREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGW 964

  Fly  1304 ----------GIGGTVARPRPQPIAGTPPPDPQEKCDQKIIQQTCNLFGLDLERPPPVPP 1353
                      .:.|||  |.|...|...|.|..:....|.....||...|...|.|...|
  Fly   965 SPPHGDRHLVKVLGTV--PGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAP 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dachs	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	227/751 (30%)
		IQCD	1219..1250	CDD:467745	13/66 (20%)
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	227/751 (30%)
		PTZ00121	<828..>943	CDD:173412	26/118 (22%)
		MyTH4	1014..1171	CDD:470587	3/9 (33%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022