DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and Myo5c

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006243475.1	Gene:	Myo5c / 315820	RGDID:	1309994	Length:	1749	Species:	Rattus norvegicus

Alignment Length:	793	Identity:	235/793 - (29%)
Similarity:	358/793 - (45%)	Gaps:	117/793 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 DLIHLSGPLTEHAVMRTLQARFNERR-YFTNVGPILLSINPYLDV---GNPL--TLTSTRAMPLA 535
            ||..|| .|.|.||:..|:.||.|.: .:|..|.||:::|||..:   |:.:  ..:......:.
  Rat    71 DLTALS-YLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMD 134

  Fly   536 PQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAAFT 600
            |.:..:.:||.:|.:.....|:||:||.||||||.:|...:|....::.........:.:.|:..
  Rat   135 PHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSSSNAHVEEKVLASNP 199

  Fly   601 VLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GALYRTKIHCYFLDQTRVIRPLPKEKNYHIF 660
            :..::|:||||.|..|||.|::.|:...:     ||..||    |.|:::||:.....|:|||||
  Rat   200 ITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRT----YLLEKSRVVFQSENERNYHIF 260

  Fly   661 YQLLAGLSREERQKLHLDGYSPANLRYLRGDI---GQNEQEDAARFQAWKTCLGILGIPFLDVVR 722
            |||.|...:.|.:.|.|......|...:.|:.   |.:::.|.|..|...|.||......:||.:
  Rat   261 YQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVDDRADMAETQKTFTLLGFKKDFQMDVFK 325

  Fly   723 VLAAVLLLGNVQFIDGGGLEVDV-KGETELNSVASLLGVPPAALFRGLTTRTHNVRGQLVKSVCG 786
            :|||:|.|||||....|.....| :.::.|.....|||:....:.:.|..|......:.|.....
  Rat   326 ILAAILHLGNVQVTTVGNERSAVSEDDSHLKVFCELLGLETIKVAQWLCNRKIVTSSETVVKPMT 390

  Fly   787 DGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGG 851
            ...|...||.|||.:|......||.:.                 |:::|..   ..||.
  Rat   391 RPQAINARDALAKKIYAHLFDFIVEQI-----------------NQALHFS---GKQHT------ 429

  Fly   852 NAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSV 916
                                 |||:||::|||....:: .|..|||...|.:|..:|.|:||...
  Rat   430 ---------------------FIGVLDIYGFETFDVNS-FEQFCINYANEKLQQQFNLHVFKLEQ 472

  Fly   917 ESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRL 980
            |....|.|.. |.:|:.||.|.||||.: :.|:|.:||.||.: .||.|:::.||.....:...|
  Rat   473 EEYMKEDIPW-TLIDFYDNQPVIDLIEA-KMGILELLDEECLLPHGTDENWLQKLYNNFVNKNSL 535

  Fly   981 ETKPTAEPHDPRM----FLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYK---HTCNFGF--- 1035
            ..|       |||    |:|:|||.:|||....||:.|||.|.|.||.|...   |.|...|
  Rat   536 FEK-------PRMSNSSFIIQHFADKVEYQCEGFLEKNRDTVYDMLVEVLRASKFHLCAAFFQES 593

  Fly  1036 --ATHLFGSELKALYAQQQ-APRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHA 1097
              .:..||:.:....|:|. .|....||                :|:...|.:.|..|:.||...
  Rat   594 PVPSSPFGAMITVKSAKQVIKPNTKHFR----------------TTVGNKFRSSLFLLMETLNAT 642

  Fly  1098 RPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRL 1162
            .||:||||:.|..:....||...:|:|:|:..||||:.:.|..:|.|..:.:|.:||.:|...:.
  Rat   643 TPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYLEFYSRYGVLMTQQE 707

  Fly  1163 LRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATL 1227
            |..|:.|  |.|:::|...::.        :..:..|:..:|...|...:||.||.:...:...:
  Rat   708 LSLSDKK--EVCKVVLHRLIQD--------SNQYQFGRTKIFFRAGQVAYLEKLRLDKLRQGCIV 762

  Fly  1228 MQATWRGWWWRKK 1240
            :|...|||..|||
  Rat   763 IQKHVRGWLQRKK 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	226/768 (29%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	217/746 (29%)
Myo5c	XP_006243475.1	Myosin_N	12..48	CDD:280832
		MYSc	62..752	CDD:214580	226/768 (29%)
		MYSc_Myo5	81..741	CDD:276831	217/746 (29%)
		IQ	755..776	CDD:197470	7/21 (33%)
		IQ	830..851	CDD:197470
		COG1340	890..1150	CDD:224259
		GBP_C	<929..1030	CDD:303769
		RILP-like	<977..1096	CDD:304877
		coiled coil	1001..1010	CDD:293879
		coiled coil	1019..1030	CDD:293879
		Myo5c_CBD	1376..1743	CDD:271260
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920