Protein Alignment dachs and Myo1a

DIOPT Version :10

• Sequence 1: NP_001188730.1
• Gene: dachs / 34179
• FlyBaseID: FBgn0262029
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_062197.1
• Gene: Myo1a / 299509
• RGDID: 3135
• Length: 1043
• Species: Rattus norvegicus
• Alignment Length: 833
• Identity: 232/833 - (27%)
• Similarity: 376/833 - (45%)
• Gaps: 151/833 - (18%)

  Fly   475 MQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPY--LDVGNPLTLTSTR---AMPL 534
            ::|||.|. ||.|.::::.||.|:.::..:|.:|.:::|:|||  |.:..|..:...|   ...|
  Rat    10 VEDLILLE-PLDEESLIKNLQLRYEKKEIYTYIGNVVISMNPYQQLPIYGPEFIAKYRDYTFYEL 73

  Fly   535 APQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFK-HLAAA 598
            .|.:..:...|.:...:....|.|:::|.||||||..:.|::..:.|:.|.|.:.::.| .|..:
  Rat    74 KPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQS 138

  Fly   599 FTVLRSLGSAKTTTNSESSRIGQFIEVQVT-DGALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQ 662
            ..||.:.|:|||..|..|||.|::::::.. .|:.....|..|.|:::||::.|..|:|:|||||
  Rat   139 NPVLEAFGNAKTIRNDNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNFHIFYQ 203

  Fly   663 LLAGLSREERQKLHLD----GYSPANLRYLRGDIGQ-NEQEDAARFQAWKTCLGILGI---PFLD 719
            ||||...:..:.|.|:    ||:     ||.|::.: |..:||:.|:|.:..:.::|.   ....
  Rat   204 LLAGADTQLLKALKLEEDARGYA-----YLNGEVSRVNGMDDASNFRAVQNAMAVIGFSEEEIRQ 263

  Fly   720 VVRVLAAVLLLGNVQFID---GGGLEV----DVKGETELNSVASLLGVPPAALFRGLTTRTHNVR 777
            |:.|.|.||.||||:..|   ..||..    |.||   :..:..::|:..|.|.:.|.:||....
  Rat   264 VLEVTALVLKLGNVKLADEFQANGLPASGVCDGKG---IQEIGEMMGLNSAELEKALCSRTMETG 325

  Fly   778 GQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVAS 842
            .:.|.:|.....|...||.|||.:|.|....||.|.|...::|:
  Rat   326 KEKVVTVLNVIQAQYARDALAKNIYSRLFDWIVNRINESIKVGT--------------------- 369

  Fly   843 QHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFY 907
                       |.|...              :|:||::|||....:: .|...||.|.|.:|..:
  Rat   370 -----------GEKRKV--------------MGVLDIYGFEILEDNS-FEQFVINYCNEKLQQVF 408

  Fly   908 NTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSVRGTAE--SYVTKL 970
            .....|...|..:.|||.. |:|:|.||....|||...:.|:|:|||.||...|...  :::.||
  Rat   409 IELTLKEEQEEYKREGIPW-TKVEYFDNGIICDLIEHSQRGILAMLDEECLRPGVVSDTTFLAKL 472

  Fly   971 KVQHRSSTRLETKPT---AEPHDPRM----FLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYK 1028
            .......:..|:|.|   ...:|..|    |.|.|:||:|.|:.|.|:|.|.|::..||....:|
  Rat   473 NQLFSKHSHYESKVTQNAQRQYDRTMGLSCFRICHYAGKVTYNVTSFIDKNNDLLFRDLSQTMWK 537

  Fly  1029 HTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRT 1093
                   |.|..   |.:|:.:.. |:..|.:..||:.:              .|...:..|::.
  Rat   538 -------AQHPL---LHSLFPEGN-PKEASLKRPPTAGT--------------QFKNSVAILMKN 577

  Fly  1094 LVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLA 1158
            |....|:::|||:.|..:....|....|:.|.|.|.:||.|.:..:|:..|..:|.|..|||:|:
  Rat   578 LYSKNPNYIRCIKPNDQQQQGRFTSELVMVQARYLGLLENVRVRRAGYAFRQAYKPFLERYRLLS 642

  Fly  1159 PFRLLR-RSEDKALEDCQLILKYAMEQPPVLDGSVTLA---WAPGKRHVFL-SEGIRQHLEHLRT 1218
            .....| ..||:  |..:.:|           ||:.|:   .|.|:..:|: |.....:||..|.
  Rat   643 RSTWPRWNGEDR--EGVEKVL-----------GSLILSSEELAYGRTKIFIRSPKTLFYLEEQRR 694

  Fly  1219 EIRHKSATLMQATWRGW------------------WWR--KKMGNGGAKRSKI 1251
            ....:.|||:|..:|||                  |:|  |:..:.|..||.:
  Rat   695 LRLQQLATLIQKVYRGWRCRTHYQQMRKSQILISAWFRGNKQKKHYGKIRSSV 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dachs	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	208/753 (28%)
		IQCD	1219..1250	CDD:467745	12/50 (24%)
Myo1a	NP_062197.1	MYSc_Myo1	22..681	CDD:276829	208/752 (28%)
		IQ	742..764	CDD:197470	2/6 (33%)
		Myosin_TH1	847..1042	CDD:461801