DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment d and Myo95E

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster

Alignment Length:	1025	Identity:	223/1025 - (21%)
Similarity:	363/1025 - (35%)	Gaps:	242/1025 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 SPNLNLSSSGAGLSASAVQQHTNGHHTTSKNHSFSHTLPANSGSGGGGGAGGGAVVSARNTSIPH 343
            :||: |....:..|||.:..|.:...::|.:.:.:..:..|......|.      ||.|.:  |.
  Fly   127 TPNV-LRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGS------VSRRQS--PS 182

  Fly   344 PLPHQLAEKPGLSHQQSGSGHGQSTGTLPHMSGMGSILGQNSHSHAPVNNNSNNSNTLPMRTSNS 408
            |.|.|.:.....|.::....|            |...:.....||   :.:|.|.:.||
  Fly   183 PGPSQRSRTRAESIERQSRRH------------MREKIVDFDFSH---HKSSENISGLP------ 226

  Fly   409 GHLGINGGGVGHHLSHAHSQQLPFIPQSKHTNPCQSVKTLPFGFGFSESQQKMQQQQQQGNSSPK 473
                      ..|..|.|..:..|..|....:.|.::.....|                   |||
  Fly   227 ----------ESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKG-------------------SPK 262

  Fly   474 DMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVGNPLTLTSTRAMPLAPQL 538
            .....::.......|:.....|:...|.|.........||        ...|.|:..|.|.....
  Fly   263 YAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLS--------TIATATTNPAHPHRGSC 319

  Fly   539 QKIV-QEAVRQQSETGYPQAIILSGT-----------------------SGAGKTANAMLMLRQL 579
            ..:: |.:...|.|....::.::..|                       |....|.:|...|.:.
  Fly   320 SNLMRQHSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRR 384

  Fly   580 FAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVT-DGALYRTKIHCYFLD 643
            ..    .|.....:.:..|...|.::|:|.|..|:.|||.|:..::::. .|......|..|.|:
  Fly   385 HK----SPTQRMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLE 445

  Fly   644 QTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHLDGY-SPANLRYLRGDIGQNEQEDAARFQAWK 707
            :||:..|:..|:|:|||||||.|...:..:.|.|  | :......||.....  :||...|...|
  Fly   446 KTRITDPIIGERNFHIFYQLLLGADLQLLKSLKL--YRNVEKYELLRNTTAM--EEDRMNFHYTK 506

  Fly   708 TCLGILGIPFLD---VVRVLAAVLLLGNVQF-----IDG-GGLEVDVKGETELNSVASLLGVPPA 763
            ..|.:||:...:   :.||:|.||.|||..|     ||| .|.:  |....|:...|.||.:...
  Fly   507 RSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQ--VSNVYEVQETAQLLNMEAQ 569

  Fly   764 ALFRGLTTRTHNVRGQLVKSVCGDGDANM---TRDCLAKALYCRTVATIVRRANSLKRLGSTLGT 825
            .|...||..  |......:.|..:.||..   .|:.|.:.||.|....:|.:.|.         :
  Fly   570 ILINCLTRA--NSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINE---------S 623

  Fly   826 LSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAH 890
            |.|...|                       |::|                :||.:|| |...|..
  Fly   624 LKSTQRE-----------------------KNLA----------------LLDFYGF-EALDHNS 648

  Fly   891 LEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDA 955
            .|...||..||.:...:..|:.:|..|....||:.. :.:||.||....:||.....|:||:::
  Fly   649 FEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEW-SRIDYFDNESICELIDKPSYGILSLIN- 711

  Fly   956 ECSVRGTAESYVTK-----LKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNR 1015
                    |.::..     |:||...:.......|..  :...|.|||:|..|.|....||:.|.
  Fly   712 --------EPHLNSNDALLLRVQQCCAGHPNFMTTGS--NSMCFQIRHYASVVNYSIHRFLEKNS 766

  Fly  1016 DVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVSTLT 1080
            |::|..:...||:...          |.:::|:.:....|.::               :..|||:
  Fly   767 DMLPKYISAAFYQSKL----------SLVQSLFPEGNPRRQVT---------------KKPSTLS 806

  Fly  1081 QDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRM 1145
            .:..|:|..||..:.|.|.|:|.||:.|..:....||.|.|..|:|.:.::..|:|..:|..:.:
  Fly   807 SNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHL 871

  Fly  1146 RFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLS---- 1206
            ...:|..||::|.............:|...||::    ..|:.....|:    |.::||:.
  Fly   872 LHVKFFHRYKLLNSLTWPHFHGGSQVEGIALIIR----NLPLPSAEFTI----GTKNVFVRSPRT 928

  Fly  1207 ----EGIRQ--------------HLEHLR---TEIRHKSATLMQATWRGW 1235
                |..|:              .:.|.|   ..:|| |..::.:.||.|
  Fly   929 VYELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRH-SQMIISSAWRTW 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	180/805 (22%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	177/760 (23%)
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568
		Motor_domain	403..924	CDD:277568	157/622 (25%)
		Myosin_TH1	1092..1267	CDD:283635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030