DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and ASPM

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_060606.3	Gene:	ASPM / 259266	HGNCID:	19048	Length:	3477	Species:	Homo sapiens

Alignment Length:	1416	Identity:	275/1416 - (19%)
Similarity:	466/1416 - (32%)	Gaps:	470/1416 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RGLKSKLQRSKSSDASSSSYERTVDFFENIPD-----FHGES----LSTFLYSPSAEQDAQAKGD 82
            ||..|||..:.:..::.:..:..:.|..  ||     .||.:    |.|.|.|....:|   ...
Human   290 RGENSKLSLTPNCSSTLNITQSQIHFLS--PDSFVNNSHGANNELELVTCLSSDMFMKD---NSQ 349

  Fly    83 EVRLER-------NRLADDDE--------DQDSESTSQSDDCEDDDVLRLCEDFLCRHRMRPDFF 132
            .|.||.       .::...|.        :||.||.|.:.....:..|:....::|..:..
Human   350 PVHLESTIAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQT---- 410

  Fly   133 CQ--YHKAVSSTTPSP---KQTKTSTPIVQCKSASPPVKVQSDLKDFKSNRTSAVVERFAKFSA- 191
            |:  .....|....||   ::::.|..|.:|:.:..|..:..:|.:.|||..|.:.:...||||
Human   411 CKVPLSNENSQVPQSPEDWRKSEVSPRIPECQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAV 475

  Fly   192 ----------------IYTLPVPKRKKAC---NKTTGNITDASSS-NEAVHLQQRLKSLSTELVT 236
                            |.:..|.|||..|   |:|..|...|... |.||...:::.:...|...
Human   476 QDISSHSHNKQPKRRPILSATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKED 540

  Fly   237 LRNRLHVGHGP--GQGQSQGNGAQPVAPAPNAGPKANNFDLNASSPNLNLSSSGAGLSASAVQQH 299
            ..:.|.: ..|  .:.:|..|...|.:...:...|..: |.:....|:.:          |:.:|
Human   541 FHSYLPI-IDPILSKSKSYKNEVTPSSTTASVARKRKS-DGSMEDANVRV----------AITEH 593

  Fly   300 TNGHHTTSKNHSFSHTLPANSGSGGGGGAGGGAVVSARNTSIPHPLPHQLAEKPGLSHQQSGSGH 364
            |.....  |...||.:.|..|           ||...:|  :..|:..:::.:..|:.::.
Human   594 TEVREI--KRIHFSPSEPKTS-----------AVKKTKN--VTTPISKRISNREKLNLKKK---- 639

  Fly   365 GQSTGTLPHMSGMGSILGQNSHSHAPVNNNSNNSNTLPMRTSNSGHLGINGGGVGHHLSHAHSQQ 429
                             ...|....|:  :..|..|.|:                  ::.|.| .
Human   640 -----------------TDLSIFRTPI--SKTNKRTKPI------------------IAVAQS-S 666

  Fly   430 LPFIPQSKHTNPCQSVKTLPFGFGFSESQQKMQQQQQQGNS-------SPKDMQDLIHLS----- 482
            |.||...|...|..   .:||........::.:::|:||.:       :|.|.....::|
Human   667 LTFIKPLKTDIPRH---PMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAA 728

  Fly   483 ----------------GPLTEHAVMR--TLQARFNER-----RYFTN------VGPILLSINP-- 516
                            .|..|...:|  |.:.|.|..     |.||:      :..:.:.|..
Human   729 TLLLGIENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARR 793

  Fly   517 ---------YLDVG------------NPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIIL 560
                     :.|||            |||.|                    |...||.|.:.|.|
Human   794 LIVRKDRHLWKDVGERQKVLNWLLSYNPLWL--------------------RIGLETTYGELISL 838

  Fly   561 SGTSGAGKTANAMLMLRQLFAIAGGGPETDA-FKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIE 624
            ...|..  |..||.:|.:|.    ..|:..| ::|                .|.....|.|.  |
Human   839 EDNSDV--TGLAMFILNRLL----WNPDIAAEYRH----------------PTVPHLYRDGH--E 879

  Fly   625 VQVTDGALYRTKIHCYFLDQTRVIRPLP-------KEKNYHIFYQLLAGLSREERQKLHLDGYSP 682
            ..::...|.:..:...|||..::.|.:.       |:..:....::|...||:     .|.|
Human   880 EALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRD-----FLSG--- 936

  Fly   683 ANLRYLRGDIGQNEQEDAARFQAWKTCLGILGIPFLDV---------------VRVLAAVLLLGN 732
                  .||:.::              ||:||:|...|               |.:...|.|:..
Human   937 ------EGDLSRH--------------LGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRT 981

  Fly   733 VQFIDGGGLEVDVKGETELNSVASLLGVPPAALFRGLTTRTHNVR--GQLVKS---VCGD--GDA 790
            ::.:            |:...::..|.:|..:..:    :.|||.  .|::||   ...|  |:.
Human   982 MELL------------TQNWDLSKKLRIPAISRLQ----KMHNVDIVLQVLKSRGIELSDEHGNT 1030

  Fly   791 NMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHN-QADVA-SQHASTIGGGNA 853
            .:::|.:.:           .|..:|:.|.........|.:.::.. :.::| .:|..:|
Human  1031 ILSKDIVDR-----------HREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSI----- 1079

  Fly   854 GSKSMAALNNAVRHATSDGFI----GILDMFGFEEPSPHAHLEHLCIN-LCAETMQHFYNTHIFK 913
             .|:::.|:     ..||..|    |..|...||:.|.:..|....:| :||     |||..:..
Human  1080 -KKTISLLS-----CHSDDLINKKKGKRDSGSFEQYSENIKLLMDWVNAVCA-----FYNKKVEN 1133

  Fly   914 SSVESCRDEGIVCDTEVDYVDNVPC---IDLISSLRTGLLSMLDAECSVRGTAESYVTKLKVQHR 975
            .:| |..|..::|.....|   .||   .|.|....|..:     ||:..|:.        |.:.
Human  1134 FTV-SFSDGRVLCYLIHHY---HPCYVPFDAICQRTTQTV-----ECTQTGSV--------VLNS 1181

  Fly   976 SSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLF 1040
            ||                          |.|.:. ||.:......:.....||         .|.
Human  1182 SS--------------------------ESDDSS-LDMSLKAFDHENTSELYK---------ELL 1210

  Fly  1041 GSELKALYAQQQAPRGLSFRISPTSHSDLLN--GDEPVSTLTQDFHTRLDNLLRTLVHARPHF-- 1101
            .:|.|..:..:.|.|.|....:..:|||:.|  .||.|..      |.|..|...|:..|...
Human  1211 ENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVI------TYLSFLCARLLDLRKEIRA 1269

  Fly  1102 VRCIRSN------GTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNA-----RY- 1154
            .|.|::.      .|:..|..:|....|.|:    |..:|.:|.   .|:| |:.||     :|
Human  1270 ARLIQTTWRKYKLKTDLKRHQEREKAARIIQ----LAVINFLAK---QRLR-KRVNAALVIQKYW 1326

  Fly  1155 -RMLAPFRLLRRSEDKALEDCQ--------------------LILKYAMEQPPVLDGSV--TLAW 1196
             |:||..:||...::| ||..|                    |.|||   ...:|...:  .:|.
Human  1327 RRVLAQRKLLMLKKEK-LEKVQNKAASLIQGYWRRYSTRQRFLKLKY---YSIILQSRIRMIIAV 1387

  Fly  1197 APGKRHVFLSEGIRQH--------LEHLRTEIRHKSATLMQATWRGWWWRK 1239
            ...||:::.:..|::|        .:..|.|:...|..::|:.:|.|..||
Human  1388 TSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRK 1438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	170/884 (19%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	165/832 (20%)
ASPM	NP_060606.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		ASH	37..134	CDD:292408
		Sufficient for interaction with KATNA1:KATNB1. /evidence=ECO:0000250\|UniProtKB:Q8CJ27	308..409		21/105 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..443		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..581		4/22 (18%)
		CH	960..1056	CDD:294029	18/122 (15%)
		CH	1114..>1171	CDD:278723	17/70 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900