DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and Myo5b

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_008770307.1	Gene:	Myo5b / 25132	RGDID:	621347	Length:	1854	Species:	Rattus norvegicus

Alignment Length:	822	Identity:	240/822 - (29%)
Similarity:	383/822 - (46%)	Gaps:	139/822 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   467 QGNSSP-----------KDMQDLIHLSGPLTEHAVMRTLQARFNERRY-FTNVGPILLSINPYLD 519
            |.|..|           .|:..|.||..|    ||:..|:.||.|..: :|..|.:|::||||..
  Rat    63 QNNQVPFLRNPDILVGENDLTALSHLHEP----AVLHNLKVRFLESNHIYTYCGIVLVAINPYEQ 123

  Fly   520 VGNPL-------TLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLR 577
            :  |:       ..:......:.|.:..:.:||.:|.:.....|:||:||.||||||.:|...:|
  Rat   124 L--PIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMR 186

  Fly   578 QLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GALYRTKI 637
            ....:.|...:|:..:.:.|:..::.::|:||||.|..|||.|::||:....     ||..||
  Rat   187 YFATVGGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRT-- 249

  Fly   638 HCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHL----DGYSPANLRYLRGDIGQNEQE 698
              |.|:::||:.....|:||||||||.|..|..|.::|.|    |.:..|:    .|:......:
  Rat   250 --YLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTAH----GGNTTIEGVD 308

  Fly   699 DAARFQAWKTCLGILGI---PFLDVVRVLAAVLLLGNVQF---IDGGGLEVDVKGETELNSVASL 757
            ||..|:..:..|.:||:   ..:.:.:::|::|.||:|:.   .||....:..:.| .|::...|
  Rat   309 DAEDFEKTRQALTLLGVRESHQISIFKIIASILHLGSVEIQAERDGDSCSISPQDE-HLSNFCRL 372

  Fly   758 LGVPPAALFRGL------TTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSL 816
            ||:..:.:...|      ||....|:...::.|..      .|:.|||.:|.:..:.||...|
  Rat   373 LGIEHSQMEHWLCHRKLVTTSETYVKTMSLQQVVN------ARNALAKHIYAQLFSWIVEHIN-- 429

  Fly   817 KRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFG 881
            |.|.::|                  .||:                           |||:||::|
  Rat   430 KALQTSL------------------KQHS---------------------------FIGVLDIYG 449

  Fly   882 FEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLR 946
            ||....:: .|..|||...|.:|..:|:|:||...|....|.|.. |.:|:.||.||||||.: :
  Rat   450 FETFEINS-FEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPW-TLIDFYDNQPCIDLIEA-K 511

  Fly   947 TGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRM----FLIRHFAGRVEYD 1006
            .|:|.:||.||.| :||.:::..||..:|.:|...:        .|||    |::.|||.:|||.
  Rat   512 LGILDLLDEECKVPKGTDQNWAQKLYERHSNSQHFQ--------KPRMSNTAFIVIHFADKVEYL 568

  Fly  1007 TTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLN 1071
            :..||:.|||.|.::.:.:.  ....|.....||..:..::.|...|....|.:|:..|...|:.
  Rat   569 SDGFLEKNRDTVYEEQINIL--KASKFPLVADLFRDDKDSVPATNTAKSRSSSKINVRSSRPLMK 631

  Fly  1072 --GDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETV 1134
              ..|...::...|.|.|:.|:.||....||:||||:.|..:....||....|:|:|:..||||:
  Rat   632 APNKEHKKSVGYQFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETI 696

  Fly  1135 NLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPG 1199
            .:.|:|:|.|..:..|..|||:|...|.|..:.||. ..|:.:|:..::.|.        .:..|
  Rat   697 RISAAGYPSRWTYHDFFNRYRVLMKKRELANTTDKK-NICKSVLESLIKDPD--------KFQFG 752

  Fly  1200 KRHVFLSEGIRQHLEHLRTEIRHKSATLM-QATWRGWWWRKK 1240
            :..:|...|...:||.||.: :.:.||:| |.|.|||..|.|
  Rat   753 RTKIFFRAGQVAYLEKLRAD-KFREATIMIQKTVRGWLQRVK 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	224/776 (29%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	217/753 (29%)
Myo5b	XP_008770307.1	MYSc	72..770	CDD:214580	225/787 (29%)
		MYSc_Myo5	91..759	CDD:276831	218/757 (29%)
		IQ	871..891	CDD:197470
		DUF1690	910..1002	CDD:285231
		Rab5-bind	919..1179	CDD:286404
		RILP-like	<979..1069	CDD:304877
		Uso1_p115_C	1155..1267	CDD:282695
		GBP_C	<1340..1416	CDD:303769
		coiled coil	1385..1396	CDD:293879
		coiled coil	1405..1416	CDD:293879
		Myo5b_CBD	1480..1851	CDD:271261
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820