Protein Alignment dachs and Myo5a

DIOPT Version :10

• Sequence 1: NP_001188730.1
• Gene: dachs / 34179
• FlyBaseID: FBgn0262029
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001423326.1
• Gene: Myo5a / 25017
• RGDID: 3143
• Length: 1877
• Species: Rattus norvegicus
• Alignment Length: 829
• Identity: 242/829 - (29%)
• Similarity: 365/829 - (44%)
• Gaps: 150/829 - (18%)

  Fly   473 KDMQ--------DLIHLSGP--------------LTEHAVMRTLQARF-NERRYFTNVGPILLSI 514
            ||::        :|.||..|              |.|.||:..|:.|| :.:..:|..|.:|::|
  Rat    46 KDLEYRLDPKTSELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAI 110

  Fly   515 NPY-------LDVGNPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANA 572
            |||       .|:.|  ..:......:.|.:..:.:||.:|.:.....|:||:||.||||||.:|
  Rat   111 NPYEQLPIYGEDIIN--AYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSA 173

  Fly   573 MLMLRQLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GAL 632
            ...:|....::|...|.:..:.:.|:..::.|:|:||||.|..|||.|::||:....     ||.
  Rat   174 KYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGAN 238

  Fly   633 YRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHL----------DGYSPANLRY 687
            .||    |.|:::||:....:|:||||||||.|.....|.:.|.|          .|.||.
  Rat   239 MRT----YLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADSFHYTKQGGSPM---- 295

  Fly   688 LRGDIGQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQFI--DGGGLEVDVKGETE 750
               ..|.::.::.|..:...|.|||.....:.:.|:||.:|.||||.|.  |.....:..|.| .
  Rat   296 ---IEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHE-P 356

  Fly   751 LNSVASLLGVPPAAL-----FRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIV 810
            |.....|:||....:     .|.|.|.|......:.|.     .|...||.|||.:|.:....||
  Rat   357 LIIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKL-----QATNARDALAKHIYAKLFNWIV 416

  Fly   811 RRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIG 875
            ...|.                                            ||::||:   ...|||
  Rat   417 GHVNQ--------------------------------------------ALHSAVK---QHSFIG 434

  Fly   876 ILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCID 940
            :||::|||....:: .|..|||...|.:|..:|.|:||...|....|.|.. |.:|:.||.|||:
  Rat   435 VLDIYGFETFEINS-FEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPW-TLIDFYDNQPCIN 497

  Fly   941 LISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVE 1004
            ||.| :.|:|.:||.||.: :||.:::..||...|.:...|..||..   ..:.|:|:|||.:||
  Rat   498 LIES-KLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRM---SNKAFIIKHFADKVE 558

  Fly  1005 YDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLS----FRISPTS 1065
            |....||:.|:|.|.::.:.|.  .:..|.....||..:.||:........|.:    ..:.||.
  Rat   559 YQCEGFLEKNKDTVFEEQIKVL--KSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTK 621

  Fly  1066 HSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQV 1130
            ........|...|:...|...|..|:.||....||:||||:.|..:...:||....|:|:|:..|
  Rat   622 GRPGQTAKEHKKTVGLQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGV 686

  Fly  1131 LETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALED----CQLILKYAMEQPPVLDGS 1191
            |||:.:.|:|||.|..:::|.:|||:|       ..:...|.|    ||.:|     :..:||..
  Rat   687 LETIRISAAGFPSRWTYQEFFSRYRVL-------MKQKDVLGDRKQTCQNVL-----EKLILDKD 739

  Fly  1192 VTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKK 1240
               .:..||..:|...|...:||.||.:....:...:|.|.|||..||:
  Rat   740 ---KYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKR 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dachs	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	222/756 (29%)
		IQCD	1219..1250	CDD:467745	7/22 (32%)
Myo5a	NP_001423326.1	COG5022	7..1445	CDD:227355	242/829 (29%)
		MYSc_Myo5	83..751	CDD:276831	222/756 (29%)
		Myo5a_CBD	1503..1877	CDD:271262