DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and Myo5c

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006510998.1	Gene:	Myo5c / 208943	MGIID:	2442485	Length:	1749	Species:	Mus musculus

Alignment Length:	820	Identity:	234/820 - (28%)
Similarity:	364/820 - (44%)	Gaps:	122/820 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 ESQQKMQQQQQQGNSSPKDMQDLIHLSGPLT------EHAVMRTLQARFNERR-YFTNVGPILLS 513
            |...:::.....|:..|....|::.....||      |.||:..|:.||.|.: .:|..|.||::
Mouse    43 EDGMELEYPVDPGSLPPLRNPDILVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVA 107

  Fly   514 INPYLDV---GNPL--TLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAM 573
            :|||..:   |:.:  ..:......:.|.:..:.:||.:|.:.....|:||:||.||||||.:|.
Mouse   108 MNPYKQLPIYGDAIIHAYSGQNMGDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSAR 172

  Fly   574 LMLRQLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GALY 633
            ..:|....::...........:.|:..:..::|:||||.|..|||.|::.|:...:     ||..
Mouse   173 YAMRYFATVSKSSSNAHVEDKVLASNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANM 237

  Fly   634 RTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHLDGYSPANLRYLRGDI---GQN 695
            ||    |.|:::||:.....|:||||||||.|...:.|.:.|.|......|...:.|:.   |.|
Mouse   238 RT----YLLEKSRVVFQSENERNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVN 298

  Fly   696 EQEDAARFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQFIDGGGLEVDV-KGETELNSVASLLG 759
            ::.|....|...|.||......:||.::|||:|.|||||....|.....| :.::.|.....|||
Mouse   299 DRADMVETQKTFTLLGFKKDFQMDVFKILAAILHLGNVQVTTVGNERSSVSEDDSHLKVFCELLG 363

  Fly   760 VPPAALFRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLG 824
            :..:.:.:.|..|......:.|........|...||.|||.:|......||.:.
Mouse   364 LETSKVAQWLCNRKIVTSSETVVKPMTRPQAINARDALAKKIYAHLFDFIVEQI----------- 417

  Fly   825 TLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHA 889
                  |:::|..   ..||.                           |||:||::|||....::
Mouse   418 ------NQALHFS---GKQHT---------------------------FIGVLDIYGFETFDVNS 446

  Fly   890 HLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLD 954
             .|..|||...|.:|..:|.|:||...|....|.|.. |.:|:.||.|.||||.: :.|:|.:||
Mouse   447 -FEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPW-TLIDFYDNQPVIDLIEA-KMGILELLD 508

  Fly   955 AECSV-RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRM----FLIRHFAGRVEYDTTDFLDTN 1014
            .||.: .||.|:::.||.....:...|..|       |||    |:|:|||.:|||....||:.|
Mouse   509 EECLLPHGTDENWLQKLYNNFVNKNSLFEK-------PRMSNSSFIIQHFADKVEYQCEGFLEKN 566

  Fly  1015 RDVVPDDLVGVFYK---HTCNFGF-----ATHLFGSELKALYAQQQ-APRGLSFRISPTSHSDLL 1070
            ||.|.|.||.:...   |.|...|     .:..||:.:....|:|. .|....||
Mouse   567 RDTVYDMLVEILRASKFHLCAAFFQESPVPSSPFGAMITVKSAKQVIKPNTKHFR---------- 621

  Fly  1071 NGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVN 1135
                  :|:...|.:.|..|:.||....||:||||:.|..:....||...:|:|:|:..||||:.
Mouse   622 ------TTVGNKFRSSLYLLMETLNATTPHYVRCIKPNDEKMPFEFDSKRIVQQLRACGVLETIR 680

  Fly  1136 LMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGK 1200
            :.|..:|.|..:.:|.:||.:|...:.|..|:.|  |.|:::|...::.        :..:..|:
Mouse   681 ISAQSYPSRWTYLEFYSRYGILMTQQELSLSDKK--EVCKVVLHRLIQD--------SNQYQFGR 735

  Fly  1201 RHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKK 1240
            ..:|...|...:||.||.:...:...::|...|||..|:|
Mouse   736 TKIFFRAGQVAYLEKLRLDKLRQDCIMIQKHVRGWLQRRK 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	223/775 (29%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	216/746 (29%)
Myo5c	XP_006510998.1	MYSc_Myo5	81..741	CDD:276831	216/746 (29%)
		DUF3584	<767..>1043	CDD:378817	5/9 (56%)
		SMC_prok_A	<922..1276	CDD:274009
		ERM	1220..>1354	CDD:366293
		Myo5c_CBD	1376..1743	CDD:271260
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820