DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and hum-10

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_508817.3	Gene:	hum-10 / 185693	WormBaseID:	WBGene00018377	Length:	853	Species:	Caenorhabditis elegans

Alignment Length:	947	Identity:	195/947 - (20%)
Similarity:	346/947 - (36%)	Gaps:	262/947 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 NKTTGNITDASSSNEAVHLQQRLKSLSTELVTLRNRLHVGHGPGQGQSQGNGAQPVAPAPNAGPK 269
            ||::..:.:.:.|.:...|:..::.||.:|..::.||...... |......|::.:.      .:
Worm    10 NKSSTMLRNPAKSVDVNRLRSDIEILSQQLEMVKARLESALAE-QDDIDEKGSKKML------SR 67

  Fly   270 ANNFDLNASSPNLNLSSSGAGLSASAVQQHTNGHHTTSKNHSFSHTLPANSGSGGGGGAGGGAVV 334
            .|:.|...|:   :|.|||:..|.:|          |...|.....:|..|.|.          :
Worm    68 DNSIDSRLST---SLFSSGSHDSCAA----------TPIPHPEQPIIPPRSNSN----------L 109

  Fly   335 SARNTSIPHPLPHQLAEKPGLSHQQSGSGHGQSTGTLPHMSGM--------------------GS 379
            |..|.::.....|...|...:|:::..... .|:...|.::.:                    |.
Worm   110 SKFNKALSMSTSHLTQEIEEISNKRLSMAL-PSSSAAPFITSLKRRETFTKVDEITKELNARIGK 173

  Fly   380 I-------LGQNSHSHAPVNNNSNNSNTLPMRTSNSGHLGINGGGVGHHLSHAHSQQLPFIPQSK 437
            :       :|.|.| ||||      ....|:||.                            |.:
Worm   174 VKRTESLSIGMNRH-HAPV------PPPKPLRTF----------------------------QEQ 203

  Fly   438 HTNPCQSVKTLPFGFGFSESQQKMQQQQQQGNSSPKDMQDLIHLSGPLTEHAVMRTLQARFNERR 502
            ...|...::|...| .||.:|:...|.....:||...:....|       ...:..:..||.:.:
Worm   204 LRKPVDQLQTNTMG-RFSNNQKFKSQTSSFMSSSVAFLSMCNH-------REFVDAINKRFTQGQ 260

  Fly   503 YFTNVGPILLSINPYLDVGNPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAG 567
            .:.:.|..|..:||:..|.:|    ......:.|.:...:.||   :|.|     :.|.|.||:|
Worm   261 CWFSRGGQLFFVNPFNTVSSP----RCNFYSVIPTITSSLFEA---KSST-----LFLRGVSGSG 313

  Fly   568 KTANAMLMLRQLF-AIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTDGA 631
            |:..|.|:...:. .:...|..:..||   .:.|:||...:|....|::.|:.......|..:..
Worm   314 KSHVAELICMDIVKRLDNQGQLSHLFK---ISITILRPFLTANNAYNNQCSKAVLHYMFQTKENR 375

  Fly   632 LYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHLDGYSPANLRYLRGDIGQNE 696
            |:|..:..:      .|..:.:....:||..:...|:..|::|..:.|:   .||....:.|
Worm   376 LHRISLKHF------PIESMSRGCRANIFAIVANDLTETEKEKYRIAGF---RLRETTFNYG--- 428

  Fly   697 QEDAARFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQF-IDGGGLEVDVKGETELNSVASLLGV 760
                 .|:..|..:.|:||...|::::::|.:||.|:.| .|....|||  ...:|...:|||||
Worm   429 -----NFEEIKAAMSIIGIDMADILKIISACILLNNINFKTDNTSSEVD--NIADLEDASSLLGV 486

  Fly   761 PPAALFRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGS---T 822
            ....::|.:      |...|:       |:.:.||.|..|||.|||..|:.:.|.|...||   .
Worm   487 SALTMYRFM------VSDALI-------DSRLIRDNLVTALYARTVKYILDKINLLLDAGSDPYD 538

  Fly   823 LGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSP 887
            .|::.:||..||           .||...|              |.     :.|:|:.|:...:.
Worm   539 RGSVVTDSGISV-----------GTINESN--------------HT-----VHIVDIPGYVRSTQ 573

  Fly   888 HAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSM 952
            :: |..|.:|...:.:|              |.|..:|             .:|:.|:..
Worm   574 NS-LNELIVNAANDIVQ--------------CTDSDMV-------------HELLKSVEI----- 605

  Fly   953 LDAECSVRGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHF--AGRVEYDTTDFLDTNR 1015
                                    :||.:...| |...|:|  |:|.  |..:.||....::.|.
Worm   606 ------------------------ATRNDEVWT-ESKSPKM--IKHCTEAFEIHYDLRLMIERNS 643

  Fly  1016 DVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQ-APRGLSFRISPTSHSDLL-NGDEPVST 1078
            :.|..:||.:|...||.|.||.:||..:::::..... ||..:::   |.:...:: |..|.:..
Worm   644 NRVSRELVNLFDFRTCTFPFAVNLFQQDIESMIVDNNYAPSAINW---PNNGKTVIQNVIESIRM 705

  Fly  1079 LTQDFHTRLDNLLRTLVHARPHFVRCIRSNGT-EAAR 1114
            |.:|.   .||..:.::        |::||.: |.||
Worm   706 LKKDI---ADNNSQQII--------CLKSNDSLEYAR 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	142/649 (22%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	141/637 (22%)
hum-10	NP_508817.3	Motor_domain	250..679	CDD:354959	126/565 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810