DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and hum-4

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001359540.1	Gene:	hum-4 / 181335	WormBaseID:	WBGene00002037	Length:	2577	Species:	Caenorhabditis elegans

Alignment Length:	875	Identity:	197/875 - (22%)
Similarity:	338/875 - (38%)	Gaps:	239/875 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   475 MQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVGNPLTL----TSTRAMPLA 535
            |.:||.|... :|..:.:.|..||.:...:|....:|:.:|.:.|..:...|    :||..:...
Worm     1 MDNLIELPDQ-SEAGIAQNLHERFKKGVTYTKASNVLVFVNDFNDKDSEDQLSWETSSTSGVNAV 64

  Fly   536 PQ--LQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAA 598
            .:  |.||...:...:|       |:..|.||:||:.|.....:.|.:.......|   ||.::.
Worm    65 AKNALNKIFNMSSNAES-------IVFGGESGSGKSYNVFKAFKYLTSQPKSKVST---KHSSSI 119

  Fly   599 FTVLRSLGSAKTTTNSESSRIGQFIEVQVTDGALYRTKI-------HCYFLDQTRVIRPLPKEKN 656
            ..|.:|.|.|||..|.|::|.|..|::      ||:..:       :...|:..|||...|.|:|
Worm   120 EFVFKSFGCAKTLKNDEATRFGCSIDL------LYKRNVLTGLNLKYTVPLEVPRVISQKPGERN 178

  Fly   657 YHIFYQLLAGLSREERQKLHLDGYSPANLRYL-RGDIGQNEQEDAARFQAWKTCLGILGIP---F 717
            ::|||::..|||.|.:.|..:.|..  ...|: :|:..:|.|.|..||:..::.|.:||..   .
Worm   179 FNIFYEVYHGLSDEMKAKFGIKGLQ--KFFYINQGNSSENIQHDVNRFKHLESALHVLGFSDDHC 241

  Fly   718 LDVVRVLAAVLLLGNVQFID--GGGLE---VDVKGETELNSVASLLGVPPAALFRGLTTRTHNVR 777
            :.:.::::.:|.:||:.|..  ...:|   |::....||..:|.||.|.               .
Worm   242 MSIYKIISTILHIGNIYFRTKRNPNVEQDVVEIGNLAELKWIAFLLEVD---------------F 291

  Fly   778 GQLVKSVCGDGDANMT---------RDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNES 833
            .||||.:....:...|         ||..|..:|......:      |.|:|..|..       |
Worm   292 DQLVKFLLPTSEDGSTIELNAALDNRDSFAMMIYEELFKWV------LNRIGLQLKC-------S 343

  Fly   834 VHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINL 898
            :|.                                   |.|.|||.:|||:.:.:. :|...||.
Worm   344 LHT-----------------------------------GVISILDHYGFEKYNNNG-VEEFLINS 372

  Fly   899 CAETMQHFYNTHIFKSSVESCRDEGIVCDTEV-DYVDNVPCIDLISSLRTGLLSMLDAECSV-RG 961
            ..|.:::.:..|.|...:.....:||..|.:| :.::|...::|:.....||||:|..||.. :|
Worm   373 VNERIENLFVKHCFHDQLIDYAKDGISVDYKVPNSIENGKTVELLFKKPYGLLSLLTDECKFPKG 437

  Fly   962 TAESYVTKLKVQH---------RSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDV 1017
            |.|:|:....:.|         |:..|||            |.:||..|...|:.|||...|:.:
Worm   438 THETYLEHCNLNHTDRSAYGKARNKERLE------------FGVRHCIGTTWYNVTDFFARNKRI 490

  Fly  1018 V-----------PDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLN 1071
            :           .:.::|:.::   ::|      |:....:.:|.|.               :|.
Worm   491 ISLSAVQLMRNSKNPIIGLLFE---SYG------GNTSDIIVSQAQF---------------VLR 531

  Fly  1072 GDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNL 1136
            |.:.::......|.              ||||||:||....:..||...|.|||::|.:.|.::.
Worm   532 GAQDIADKINVSHV--------------HFVRCIKSNNERQSTKFDIPLVNRQIKNLLLAELLSF 582

  Fly  1137 MASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLIL-----KYAMEQPPVLDGSVTLAW 1196
            ...|:|.::....|..:||.|.|..:.:...:|  |..|.||     ||..:            :
Worm   583 RVKGYPVKISKTTFARQYRCLLPGDIAQCQNEK--EIIQDILQGQGVKYEDD------------F 633

  Fly  1197 APGKRHVFLSEGIRQHLEHLRTEI----------------------RHKSATL-MQATWRGWWWR 1238
            ..|..:|||.|.:.:..:.|:.:|                      |.::|.: :|:..|||..|
Worm   634 KIGTEYVFLRERLAERYDGLQNKICGDAAIIIQKNMKSFVAQKVYKRMRAAIIKLQSGLRGWKAR 698

  Fly  1239 -----------KKMGNGGAKRSKIPGLQQA 1257
                       |.:|....:..::....||
Worm   699 RDYIIKREEMFKAIGRTMKRNKRLDAYHQA 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	183/798 (23%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	177/775 (23%)
hum-4	NP_001359540.1	MYSc_Myo12	13..643	CDD:276841	177/775 (23%)
		IQ	680..701	CDD:197470	7/20 (35%)
		MyTH4	803..952	CDD:214535
		PRK10263	<1162..>1357	CDD:236669
		SH3	1974..2030	CDD:388381
		MyTH4	2100..2255	CDD:214535
		B41	2262..2475	CDD:214604
		PH-like	2489..2563	CDD:388408
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158913
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840