DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and Myo5b

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006525777.1	Gene:	Myo5b / 17919	MGIID:	106598	Length:	1849	Species:	Mus musculus

Alignment Length:	822	Identity:	241/822 - (29%)
Similarity:	384/822 - (46%)	Gaps:	140/822 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   467 QGNSSP-----------KDMQDLIHLSGPLTEHAVMRTLQARFNERRY-FTNVGPILLSINPYLD 519
            |.|..|           .|:..|.||..|    ||:..|:.||.|..: :|..|.:|::||||..
Mouse    55 QNNQVPFLRNPDILVGENDLTALSHLHEP----AVLHNLKVRFLESNHIYTYCGIVLVAINPYEQ 115

  Fly   520 VGNPL-------TLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLR 577
            :  |:       ..:......:.|.:..:.:||.:|.:.....|:||:||.||||||.:|...:|
Mouse   116 L--PIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMR 178

  Fly   578 QLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GALYRTKI 637
            ....:.|...:|:..:.:.|:..::.::|:||||.|..|||.|:|||:....     ||..||
Mouse   179 YFATVGGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKFIEIGFDKKYHIIGANMRT-- 241

  Fly   638 HCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHL----DGYSPANLRYLRGDI---GQN 695
              |.|:::||:.....|:||||||||.|..|..|.::|.|    |.:..|:    .|:.   |.|
Mouse   242 --YLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTAH----GGNTTIEGVN 300

  Fly   696 EQEDAARFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQF---IDGGGLEVDVKGETELNSVASL 757
            :.:|..:.:...|.||:.....:.:.:::|::|.||:|:.   .||....:..:.| .|::..||
Mouse   301 DADDFEKTRQALTLLGVRDSHQISIFKIIASILHLGSVEIQSERDGDSCSISPQDE-HLSNFCSL 364

  Fly   758 LGVPPAALFRGL------TTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSL 816
            ||:..:.:...|      ||....|:...::.|..      .||.|||.:|.:..:.||...|
Mouse   365 LGIEHSQMEHWLCHRKLVTTSETYVKTMSLQQVVN------ARDALAKHIYAQLFSWIVEHIN-- 421

  Fly   817 KRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFG 881
            |.|.::|                  .||:                           |||:||::|
Mouse   422 KALHTSL------------------KQHS---------------------------FIGVLDIYG 441

  Fly   882 FEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLR 946
            ||....:: .|..|||...|.:|..:|:|:||...|....|.|.. |.:|:.||.||||||.: :
Mouse   442 FETFEINS-FEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPW-TLIDFYDNQPCIDLIEA-K 503

  Fly   947 TGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRM----FLIRHFAGRVEYD 1006
            .|:|.:||.||.| :||.:::..||..:|.:|...:        .|||    |::.|||.:|||.
Mouse   504 LGILDLLDEECKVPKGTDQNWAQKLYERHSNSQHFQ--------KPRMSNTAFIVNHFADKVEYL 560

  Fly  1007 TTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLN 1071
            :..||:.|||.|.::.:.:.  ....|.....||..:..:..|...|....|.:|:..|...|:.
Mouse   561 SDGFLEKNRDTVYEEQINIL--KASKFPLVADLFHDDKDSAPATNTAKNRSSSKINVRSSRPLIK 623

  Fly  1072 --GDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETV 1134
              ..|...::...|.|.|:.|:.||....||:||||:.|..:....||....|:|:|:..||||:
Mouse   624 VPNKEHKKSVGYQFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETI 688

  Fly  1135 NLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPG 1199
            .:.|:|:|.|..:..|..|||:|...|.|..::.|.:  |:.:|:..::.|.        .:..|
Mouse   689 RISAAGYPSRWTYHDFFNRYRVLMKKRELTNTDKKNI--CKSVLESLIKDPD--------KFQFG 743

  Fly  1200 KRHVFLSEGIRQHLEHLRTEIRHKSATLM-QATWRGWWWRKK 1240
            :..:|...|...:||.||.: :.:.||:| |.:.|||..|.|
Mouse   744 RTKIFFRAGQVAYLEKLRAD-KFREATIMIQKSVRGWLQRVK 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	226/776 (29%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	219/753 (29%)
Myo5b	XP_006525777.1	COG5022	11..>1268	CDD:227355	241/822 (29%)
		MYSc_Myo5	83..750	CDD:276831	220/757 (29%)
		EnvC	1136..>1449	CDD:227278
		Myo5b_CBD	1475..1846	CDD:271261
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820