DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and Myo5a

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006510890.1	Gene:	Myo5a / 17918	MGIID:	105976	Length:	1880	Species:	Mus musculus

Alignment Length:	825	Identity:	241/825 - (29%)
Similarity:	365/825 - (44%)	Gaps:	142/825 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 KDMQ--------DLIHLSGP--------------LTEHAVMRTLQARF-NERRYFTNVGPILLSI 514
            ||::        :|.||..|              |.|.||:..|:.|| :.:..:|..|.:|::|
Mouse    46 KDLEYRLDPKTGELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAI 110

  Fly   515 NPY-------LDVGNPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANA 572
            |||       .|:.|  ..:......:.|.:..:.:||.:|.:.....|:||:||.||||||.:|
Mouse   111 NPYEQLPIYGEDIIN--AYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSA 173

  Fly   573 MLMLRQLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GAL 632
            ...:|....::|...|.:..:.:.|:..::.|:|:||||.|..|||.|::||:....     ||.
Mouse   174 KYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGAN 238

  Fly   633 YRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHL----------DGYSPANLRY 687
            .||    |.|:::||:....:|:||||||||.|.....|.:.|.|          .|.||.
Mouse   239 MRT----YLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADSFHYTKQGGSPM---- 295

  Fly   688 LRGDIGQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQFI--DGGGLEVDVKGETE 750
               ..|.::.::.|..:...|.|||.....:.:.|:||.:|.||||.|.  |.....:..|.| .
Mouse   296 ---IEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHE-P 356

  Fly   751 LNSVASLLGVPPAAL-----FRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIV 810
            |.....|:||....:     .|.|.|.|......:.|.     .|...||.|||.:|.:....||
Mouse   357 LTIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKL-----QATNARDALAKHIYAKLFNWIV 416

  Fly   811 RRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIG 875
            ...|.                                            ||::||:   ...|||
Mouse   417 DHVNQ--------------------------------------------ALHSAVK---QHSFIG 434

  Fly   876 ILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCID 940
            :||::|||....:: .|..|||...|.:|..:|.|:||...|....|.|.. |.:|:.||.|||:
Mouse   435 VLDIYGFETFEINS-FEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPW-TLIDFYDNQPCIN 497

  Fly   941 LISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVE 1004
            ||.| :.|:|.:||.||.: :||.:::..||...|.:...|..||..   ..:.|:|:|||.:||
Mouse   498 LIES-KLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRM---SNKAFIIKHFADKVE 558

  Fly  1005 YDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLS----FRISPTS 1065
            |....||:.|:|.|.::.:.|.  .:..|.....||..:.||:........|.:    ..:.||.
Mouse   559 YQCEGFLEKNKDTVFEEQIKVL--KSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTK 621

  Fly  1066 HSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQV 1130
            ........|...|:...|...|..|:.||....||:||||:.|..:...:||....|:|:|:..|
Mouse   622 GRPGQTAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGV 686

  Fly  1131 LETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLA 1195
            |||:.:.|:|||.|..:::|.:|||:|       ..:...|.|.:...|..:|: .:||..   .
Mouse   687 LETIRISAAGFPSRWTYQEFFSRYRVL-------MKQKDVLGDRKQTCKNVLEK-LILDKD---K 740

  Fly  1196 WAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKK 1240
            :..||..:|...|...:||.||.:....:...:|.|.|||..||:
Mouse   741 YQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKR 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	230/797 (29%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	221/752 (29%)
Myo5a	XP_006510890.1	COG5022	7..1448	CDD:227355	241/825 (29%)
		MYSc_Myo5	83..751	CDD:276831	221/752 (29%)
		Myo5a_CBD	1506..1880	CDD:271262
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820