Protein Alignment prg and ZNF341

DIOPT Version :10

• Sequence 1: NP_609232.2
• Gene: prg / 34177
• FlyBaseID: FBgn0285971
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_001269862.1
• Gene: ZNF341 / 84905
• HGNCID: 15992
• Length: 854
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 127/574 - (22%)
• Similarity: 200/574 - (34%)
• Gaps: 174/574 - (30%)

  Fly    64 ELICSRCLEILEEAFELRKGMQE-------------REQSLQEQLKEMIKDHPKHRPGLNGNPGV 115
            :|.||.|.:...:.|:|::.::.             |..:.:..:|:.::.|....||.:|.
Human   321 KLKCSYCDKSFTKNFDLQQHIRSHTGEKPFQCIACGRAFAQKSNVKKHMQTHKVWPPGHSGG--- 382

  Fly   116 FVPEEGCIIVEVDPENLAESSEEEF--------------ALGSDGEYENYDDDDEEEEEDYDEED 166
             ......:.|:|...|.:...:||.              ||.:.|
Human   383 -TVSRNSVTVQVMALNPSRQEDEESTGLGQPLPGAPQPQALSTAG-------------------- 426

  Fly   167 EEDGQNGEDVDMPLGMDAA--------------QMAAQQSVANN--------ANTTEARPK---- 205
            ||:|...|...:.| :|::              |:.:..:...|        .:..:..||
Human   427 EEEGDKPESKQVVL-IDSSYLCQFCPSKFSTYFQLKSHMTQHKNEQVYKCVVKSCAQTFPKLDTF 490

  Fly   206 ----------RAFLCQYCDLGFTLPAECQEHE-----LAAHDP---NAPYCCNFCNIKLVTRPAL 252
                      .::.|..|...|....:...|:     |..|.|   ||.|.|..|..|..|..||
Human   491 LEHIKSHQEELSYRCHLCGKDFPSLYDLGVHQYSHSLLPQHSPKKDNAVYKCVKCVNKYSTPEAL 555

  Fly   253 ISHIKT-LHDPDRPYVCAHCRKGFVRRSDLKKHTIVHTGVRPFTCNVCSKSFSRNTNLTKHMRIH 316
            ..|::| .|:    :.|.||:|.|.....|::|...|.....|.|.||.|.|.|...|..|..||
Human   556 EHHLQTATHN----FPCPHCQKVFPCERYLRRHLPTHGSGGRFKCQVCKKFFRREHYLKLHAHIH 616

  Fly   317 SGVKPFVCQQCPRSFQTAVEMMRHTRSHGEVKAFQCGRCPYS--------FSRRDKLIAHQQVHT 373
            ||.||:.|..|..:|....::.||...|...|.:   :||:|        |:|.|||.||...|:
Human   617 SGEKPYKCSVCESAFNRKDKLKRHMLIHEPFKKY---KCPFSTHTGCSKEFNRPDKLKAHILSHS 678

  Fly   374 RRDMEQQQQMGLIPPMEGDLQQQALQAKQKAAAQTKNSRYYHCDVCDRTFQRERDLQRHQALHMD 438
                                                ..:.:.|.:|.::|.|...|..||..|..
Human   679 ------------------------------------GMKLHKCALCSKSFSRRAHLAEHQRAHTG 707

  Fly   439 SL-FACKTCNQGFNRREQLQRH----------ELEAHGP------SFTCGICCISFLHQIELENH 486
            :. |.|..|.:||:|.:.|:.|          :|:...|      ..:||......|  ..|.:.
Human   708 NYKFRCAGCAKGFSRHKYLKDHRCRLGPQKDKDLQTRRPPQRRAAPRSCGSGGRKVL--TPLPDP 770

  Fly   487 LKVHQLQHKMAQRAQEAAILPLKMAEKAPVAMTAPLV-----QDPQLVRPSAAE 535
            |.:.:|:...|....||  :|.|.....|.|:.:.:|     .:.:||.|..||
Human   771 LGLEELKDTGAGLVPEA--VPGKPPFAEPDAVLSIVVGGAVGAETELVVPGHAE 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prg	NP_609232.2	zf-AD	16..94	CDD:462262	7/42 (17%)
		COG5048	<212..340	CDD:227381	44/136 (32%)
		C2H2 Zn finger	239..260	CDD:275368	8/21 (38%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..372	CDD:275368	10/27 (37%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		C2H2 Zn finger	443..464	CDD:275368	8/30 (27%)
		C2H2 Zn finger	470..490	CDD:275368	5/19 (26%)
ZNF341	NP_001269862.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..217
		KREPA	<237..>374	CDD:483960	9/52 (17%)
		COG5048	323..729	CDD:227381	104/473 (22%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..372	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..434		8/54 (15%)
		C2H2 Zn finger	447..467	CDD:275368	1/19 (5%)
		C2H2 Zn finger	475..497	CDD:275368	2/21 (10%)
		C2H2 Zn finger	505..525	CDD:275368	4/19 (21%)
		C2H2 Zn finger	542..562	CDD:275370	7/19 (37%)
		C2H2 Zn finger	568..588	CDD:275368	7/19 (37%)
		C2H2 Zn finger	596..616	CDD:275368	8/19 (42%)
		C2H2 Zn finger	624..644	CDD:275368	5/19 (26%)
		C2H2 Zn finger	652..677	CDD:275368	10/24 (42%)
		C2H2 Zn finger	685..705	CDD:275368	7/19 (37%)
		C2H2 Zn finger	713..730	CDD:275368	6/16 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	731..763		4/31 (13%)