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Protein Alignment prg and ZNF112

DIOPT Version :10

Sequence 1:	NP_609232.2	Gene:	prg / 34177	FlyBaseID:	FBgn0285971	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001335210.1	Gene:	ZNF112 / 7771	HGNCID:	12892	Length:	930	Species:	Homo sapiens

Alignment Length:	555	Identity:	138/555 - (24%)
Similarity:	220/555 - (39%)	Gaps:	116/555 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHTSDIS---------MTQDQDVSTCRLCHHNTDPNSL----NIFDDTVQFCKDV--SIAEVSKS 50
            :||.::|         .:...|:::....|...:|:..    |:|:.:  .|..|  .|....|.
Human   369 IHTGEMSYRHNIYEKAFSHSLDLNSIFRVHTRDEPHEYEENENVFNQS--SCLQVHQKIHTEEKL 431

  Fly    51 LWSVQYDRNECLSELICSRCLEILEEAFELRKGMQEREQSLQE-----QLKEMIKD----HPKHR 106
            ...::|.::     .|||..|:|     :.|..|:|...:.:|     .|....:|    |.|.:
Human   432 YTDIEYGKS-----FICSSNLDI-----QHRVHMEENSYNSEECGNGFSLASHFQDLQIVHTKEQ 486

  Fly   107 P--------------GLNGNPGVFVPEEGCIIVEVDPENLAESSEEEFALGSDGEYENYDDDDEE 157
            |              .|.|:|.:               ::.|...:|...|.     |:....:
Human   487 PYKRYVCSNSFSHNLYLQGHPKI---------------HIGEKPRKEHGNGF-----NWSSKLK- 530

  Fly   158 EEEDYDEEDEEDGQNGEDVDMPLGMDAAQMAAQQSVANNANTTEARPKRAFLCQYCDLGFTLPAE 222
                 |.:....||.      |...:............|.:......::.:.|:.||.||:..:.
Human   531 -----DHQRVHTGQK------PYKCNICGKGFNHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSY 584

  Fly   223 CQEHELAAHDPNAPYCCNFCNIKLVTRPALISHIKTLHDPDRPYVCAHCRKGFVRRSDLKKHTIV 287
            .|.|: ..|....||.|..|. |..:|.:.:...:.:|..::||.|..|.|||.|.|.|:.|..|
Human   585 LQAHQ-RVHTGEKPYKCEECG-KGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHQRV 647

  Fly   288 HTGVRPFTCNVCSKSFSRNTNLTKHMRIHSGVKPFVCQQCPRSFQTAVEMMRHTRSHGEVKAFQC 352
            |||.:||.|..|.|.||.:.||..|.|:|:|.||:.|::|.:.|..|..::.|.|.|...|.:||
Human   648 HTGEKPFKCEECGKGFSWSFNLQIHQRVHTGEKPYKCEECGKGFSKASTLLAHQRVHTGEKPYQC 712

  Fly   353 GRCPYSFSRRDKLIAHQQVHTRRDMEQQQQMGLIPPMEGDLQQQALQAKQKAAAQTK-------- 409
            ..|..|||:|..|.:||.||:.......:..|     :|..|:..||..|:...:.|
Human   713 DECGKSFSQRSYLQSHQSVHSGERPYICEVCG-----KGFSQRAYLQGHQRVHTRVKPYKCEMCG 772

  Fly   410 -----NSRY------------YHCDVCDRTFQRERDLQRHQALHMDSL-FACKTCNQGFNRREQL 456
                 :||.            |.|:||.:.|.....||.||.:|::.. :.|:.|.:||:....|
Human   773 KGFSQSSRLEAHRRVHTGGKPYKCEVCTKGFSESSRLQAHQRVHVEGRPYKCEQCGKGFSGYSSL 837

  Fly   457 QRHELEAHGPS-FTCGICCISFLHQIELENHLKVH 490
            |.|.....|.. :.|.:|...|..:..|:.|.:||
Human   838 QAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVH 872

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.