Protein Alignment prg and ZBTB17

DIOPT Version :10

• Sequence 1: NP_609232.2
• Gene: prg / 34177
• FlyBaseID: FBgn0285971
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_001274532.1
• Gene: ZBTB17 / 7709
• HGNCID: 12936
• Length: 810
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 142/598 - (23%)
• Similarity: 221/598 - (36%)
• Gaps: 171/598 - (28%)

  Fly     1 MHTSDISMT--------------QDQDVSTCRLCHHNTDPNSLNIFDDTVQFCKDVSIAEVSKS- 50
            |:|:.:|::              |.||:.|.  ||      :|.            |:||.:.|
Human    77 MYTAKLSLSPENVDDVLAVATFLQMQDIITA--CH------ALK------------SLAEPATSP 121

  Fly    51 -----LWSVQYDRNECLSELICSRCLEILEEA------------FELRKGMQEREQSLQEQLKEM 98
                 ..:.:........|.:.:..|..||:|            .|.|.|..:...|..||.::
Human   122 GGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGAEQTEK- 185

  Fly    99 IKDHPKHRPGLNGNPGVFVPEEGCIIVEVDPENLAESSEEEFAL--GSDGEYENYDDDDEEEEED 161
             .|.|:..|.:...|.   |..|....|.:.. |:||||:|..:  ...||.|..:.:::|||..
Human   186 -ADAPREPPPVELKPD---PTSGMAAAEAEAA-LSESSEQEMEVEPARKGEEEQKEQEEQEEEGA 245

  Fly   162 YDEEDEEDG---QNGE-----DVDMPLGMDAAQMAAQQSVANNANT----TEARP---------- 204
            ...|.:|:|   :|||     :.:...|.|:.|....::....:.|    ||::.
Human   246 GPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCED 310

  Fly   205 --------------------KRAFLCQYCDLGFTLPAECQEHELA-------------------- 229
                                ::.|.|:.|...|:.||.|:.||..
Human   311 CGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLIS 375

  Fly   230 -----------------------------------AHDPNAPYCCNFCNIKLVTRPALISHIKTL 259
                                               .|....||.|::|........:.:.|::|
Human   376 LLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLET- 439

  Fly   260 HDPDRPYVCAHCRKGFVRRSDLKKHTIVHTGVRPFTCNVCSKSFSRNTNLTKHMRIHSGVKPFVC 324
            ||.|:.:.|.||.|.|.:..:||.|..:|....|..|..|.|.|:.:.||.:|:|||||.||:||
Human   440 HDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVC 504

  Fly   325 QQCPRSFQTAVEMMRHTRSHGEVKAFQCGRCPYSFSRRDKLIAHQQVHTRRDMEQQQQMGLIPPM 389
            ..|.|.|.....:.||.|.|...|..||..|..:|::...||||.:.||.......::.|
Human   505 IHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCG----- 564

  Fly   390 EGDLQQQALQAKQKA--AAQTKNSRYYHCDVCDRTFQRERDLQRHQALHM-DSLFACKTCNQGFN 451
                 ::.:|:.|.|  .....|.|.:.|.||.:.|....||.:|..:|. :..:.|..|.:|||
Human   565 -----KRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFN 624

  Fly   452 RREQLQRHELEAH 464
            |.:.|:.|....|
Human   625 RVDNLRSHVKTVH 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prg	NP_609232.2	zf-AD	16..94	CDD:462262	17/95 (18%)
		COG5048	<212..340	CDD:227381	46/182 (25%)
		C2H2 Zn finger	239..260	CDD:275368	4/20 (20%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		C2H2 Zn finger	443..464	CDD:275368	8/20 (40%)
		C2H2 Zn finger	470..490	CDD:275368
ZBTB17	NP_001274532.1	BTB_POZ_ZBTB17_MIZ1	2..113	CDD:349515	10/55 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..295		42/184 (23%)
		Interaction with MYC	269..308		6/38 (16%)
		COG5048	306..637	CDD:227381	85/341 (25%)
		C2H2 Zn finger	308..328	CDD:275368	0/19 (0%)
		C2H2 Zn finger	336..356	CDD:275368	8/19 (42%)
		C2H2 Zn finger	364..384	CDD:275368	0/19 (0%)
		C2H2 Zn finger	392..412	CDD:275368	0/19 (0%)
		C2H2 Zn finger	420..440	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..468	CDD:275368	8/19 (42%)
		C2H2 Zn finger	476..496	CDD:275368	8/19 (42%)
		C2H2 Zn finger	504..524	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275368	7/19 (37%)
		C2H2 Zn finger	560..580	CDD:275368	4/29 (14%)
		C2H2 Zn finger	588..608	CDD:275368	7/19 (37%)
		C2H2 Zn finger	616..635	CDD:275370	8/18 (44%)
		C2H2 Zn finger	726..746	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	786..810