DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment prg and ZNF221

DIOPT Version :10

Sequence 1:NP_609232.2 Gene:prg / 34177 FlyBaseID:FBgn0285971 Length:558 Species:Drosophila melanogaster
Sequence 2:NP_037491.2 Gene:ZNF221 / 7638 HGNCID:13014 Length:617 Species:Homo sapiens


Alignment Length:506 Identity:131/506 - (25%)
Similarity:198/506 - (39%) Gaps:100/506 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 SLNIFDDTVQFCKDVSI---AEVSKSLWSVQ---YDRNEC---LSELICSRCLEILEEAFELRKG 83
            |.|...::.||.|:..:   .|...|:..||   |..|||   .|::          ..|:|.:.
Human   136 SQNSIRNSSQFFKEGDVPCQIEARLSISHVQQKPYRCNECKQSFSDV----------SVFDLHQQ 190

  Fly    84 MQEREQSLQEQLKEMIKDHPKHRPGLNGNPGVFVPE----------EGCIIVEVDPENLAESS-- 136
            ....|:|              |..|..|....:.|.          |.|...:|..:...:||  
Human   191 SHSGEKS--------------HTCGECGKSFCYSPALHIHQRVHMGEKCYKCDVCGKEFNQSSHL 241

  Fly   137 ---------EEEFALGSDGE------YENYDDDDEEEEEDYDEEDEEDGQNGEDVDMPLGMDAAQ 186
                     |:.|..|..|:      ..|........|:.|:  .||.|:        ..:..:|
Human   242 QTHQRVHTGEKPFKCGQCGKGFHSRSALNVHCKLHTGEKPYN--CEECGK--------AFIHDSQ 296

  Fly   187 MAAQQSVANNANTTEARPKRAFLCQYCDLGFTLPAECQEHELAAHDPNAPYCCNFCNIKLVTRPA 251
            :...|.:    :|.|    :.|.|..|...|.:.:....|.: .|....|:.|:.|......|.|
Human   297 LQEHQRI----HTGE----KPFKCDICGKSFRVRSRLNRHSM-VHTGEKPFRCDTCGKNFRQRSA 352

  Fly   252 LISHIKTLHDPDRPYVCAHCRKGFVRRSDLKKHTIVHTGVRPFTCNVCSKSFSRNTNLTKHMRIH 316
            |.|| ..:|..::||.|..|.|||:.|.|..||.:||||.:|:.|..|.|:|..::.|..|.::|
Human   353 LNSH-SMVHIEEKPYKCEQCGKGFICRRDFCKHQMVHTGEKPYNCKECGKTFRWSSCLLNHQQVH 416

  Fly   317 SGVKPFVCQQCPRSFQTAVEMMRHTRSHGEVKAFQCGRCPYSFSRRDKLIAHQQVHTRRD----M 377
            ||.|.|.|::|.:.|.|......|.|||...|.:.|..|...:.||..|..||:|||...    .
Human   417 SGQKSFKCEECGKGFYTNSRRSSHQRSHNGEKPYNCEECGKDYKRRLDLEFHQRVHTGERPYNCK 481

  Fly   378 EQQQQMGLIPPMEGDLQQQALQAKQKAAAQTKNSRYYHCDVCDRTFQRERDLQRHQALHM-DSLF 441
            |..:..|....:   |:.|.|.:.:|.         :.|:.|.:.|.:...|..||..|. :.|:
Human   482 ECGKSFGWASCL---LKHQRLHSGEKP---------FKCEECGKRFTQSSQLHSHQTCHTGEKLY 534

  Fly   442 ACKTCNQGFNRREQLQRHELEAHGPS--FTCGICCISFLHQIELENHLKVH 490
            .|:.|.:|:|.:..|..|: ..||..  :.|..|..||.....|..|.::|
Human   535 KCEQCEKGYNSKFNLDMHQ-RVHGGERPYNCKECGKSFGWASCLLKHQRLH 584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
prgNP_609232.2 zf-AD 16..94 CDD:462262 18/74 (24%)
COG5048 <212..340 CDD:227381 44/127 (35%)
C2H2 Zn finger 239..260 CDD:275368 7/20 (35%)
C2H2 Zn finger 268..288 CDD:275368 9/19 (47%)
C2H2 Zn finger 296..316 CDD:275368 6/19 (32%)
C2H2 Zn finger 324..344 CDD:275368 6/19 (32%)
C2H2 Zn finger 352..372 CDD:275368 7/19 (37%)
C2H2 Zn finger 416..436 CDD:275368 6/19 (32%)
C2H2 Zn finger 443..464 CDD:275368 6/20 (30%)
C2H2 Zn finger 470..490 CDD:275368 6/19 (32%)
ZNF221NP_037491.2 KRAB 30..70 CDD:460171
COG5048 166..576 CDD:227381 120/466 (26%)
C2H2 Zn finger 172..192 CDD:275368 6/29 (21%)
C2H2 Zn finger 200..220 CDD:275368 3/19 (16%)
C2H2 Zn finger 228..248 CDD:275368 3/19 (16%)
C2H2 Zn finger 256..276 CDD:275368 3/19 (16%)
C2H2 Zn finger 284..304 CDD:275368 5/31 (16%)
C2H2 Zn finger 312..332 CDD:275368 4/20 (20%)
C2H2 Zn finger 340..360 CDD:275368 7/20 (35%)
C2H2 Zn finger 368..388 CDD:275368 9/19 (47%)
C2H2 Zn finger 396..416 CDD:275368 6/19 (32%)
C2H2 Zn finger 424..444 CDD:275368 6/19 (32%)
C2H2 Zn finger 452..472 CDD:275368 7/19 (37%)
C2H2 Zn finger 480..500 CDD:275368 4/22 (18%)
C2H2 Zn finger 508..528 CDD:275368 6/19 (32%)
C2H2 Zn finger 536..556 CDD:275368 6/20 (30%)
C2H2 Zn finger 564..584 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.