Protein Alignment prg and ZBTB4

DIOPT Version :10

• Sequence 1: NP_609232.2
• Gene: prg / 34177
• FlyBaseID: FBgn0285971
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_065950.2
• Gene: ZBTB4 / 57659
• HGNCID: 23847
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 64/284 - (22%)
• Similarity: 88/284 - (30%)
• Gaps: 90/284 - (31%)

  Fly   107 PGLNGNPGVFVPEEGCI------------------IVEVDPENLAESSEEEFALGSD----GEYE 149
            || .|..|..|.|.|.:                  .|...|..:|.|..||.:.|..    ||:|
Human   151 PG-GGGDGAAVAEIGALGRRLGISRLQGLGEGGDAWVPPTPAPMATSQPEEDSFGPGPRPAGEWE 214

  Fly   150 NYDDDDEEEEEDYDEEDEEDGQNGEDVDMPLGMDAAQMAAQQSVANNANTTEARPKRAFLCQYCD 214
            .               |..:.| ..|:...|                       |:|...|..|.
Human   215 G---------------DRAEAQ-APDLQCSL-----------------------PRRPLPCPQCG 240

  Fly   215 LGFTLPAECQEHELAAH----------------DPNAPYCCNFCNIKLVTRPALI------SHIK 257
            ..|..|...|.||....                .|..|     ..:.....|..:      .|:.
Human   241 KSFIHPKRLQTHEAQCRRGASTRGSTGLGAGGAGPGGP-----AGVDASALPPPVGFRGGPEHVV 300

  Fly   258 TLHDPDRPYVCAHCRKGFVRRSDLKKHTIVHTGVRPFTCNVCSKSFSRNTNLTKHMRIHSGVKPF 322
            .:......||||.|.:.:|..|.||:|:.||:..|.:.|..|.|.|:.....|||...|:|.:.:
Human   301 KVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHTGERRY 365

  Fly   323 VCQQCPRSFQTAVEMMRHTRS-HG 345
            .|..|..:|.|...:..|.|: ||
Human   366 QCIFCWETFVTYYNLKTHQRAFHG 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prg	NP_609232.2	zf-AD	16..94	CDD:462262
		COG5048	<212..340	CDD:227381	36/149 (24%)
		C2H2 Zn finger	239..260	CDD:275368	2/26 (8%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		C2H2 Zn finger	324..344	CDD:275368	6/20 (30%)
		C2H2 Zn finger	352..372	CDD:275368
		C2H2 Zn finger	416..436	CDD:275368
		C2H2 Zn finger	443..464	CDD:275368
		C2H2 Zn finger	470..490	CDD:275368
ZBTB4	NP_065950.2	BTB_POZ	12..181	CDD:453885	7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..124
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..221		11/52 (21%)
		Interaction with CBFA2T3. /evidence=ECO:0000269|PubMed:23251453	186..348		44/205 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..281		2/28 (7%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		C2H2 Zn finger	367..385	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..765
		C2H2 Zn finger	728..748	CDD:275368
		zf-C2H2	765..787	CDD:395048
		C2H2 Zn finger	767..787	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..852
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	883..904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..1013