DRSC/TRiP Functional Genomics Resources

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Protein Alignment prg and ZNF281

DIOPT Version :10

Sequence 1:NP_609232.2 Gene:prg / 34177 FlyBaseID:FBgn0285971 Length:558 Species:Drosophila melanogaster
Sequence 2:NP_036614.1 Gene:ZNF281 / 23528 HGNCID:13075 Length:895 Species:Homo sapiens


Alignment Length:125 Identity:46/125 - (36%)
Similarity:69/125 - (55%) Gaps:2/125 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly   248 TRPALISHIK--TLHDPDRPYVCAHCRKGFVRRSDLKKHTIVHTGVRPFTCNVCSKSFSRNTNLT 310
            ::|:|:...:  .|....:|::|.||...|.....|::|.::|||.|||.|:.||..|.:...|.
Human   241 SKPSLVGDGEGAILSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQ 305

  Fly   311 KHMRIHSGVKPFVCQQCPRSFQTAVEMMRHTRSHGEVKAFQCGRCPYSFSRRDKLIAHQQ 370
            :|.:|||..|||.|.||...|.....|.||.|:|...|.::|..|...|||.|:|:.|::
Human   306 RHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRR 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
prgNP_609232.2 zf-AD 16..94 CDD:462262
COG5048 <212..340 CDD:227381 33/93 (35%)
C2H2 Zn finger 239..260 CDD:275368 2/13 (15%)
C2H2 Zn finger 268..288 CDD:275368 6/19 (32%)
C2H2 Zn finger 296..316 CDD:275368 6/19 (32%)
C2H2 Zn finger 324..344 CDD:275368 8/19 (42%)
C2H2 Zn finger 352..372 CDD:275368 8/19 (42%)
C2H2 Zn finger 416..436 CDD:275368
C2H2 Zn finger 443..464 CDD:275368
C2H2 Zn finger 470..490 CDD:275368
ZNF281NP_036614.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 63..113
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..149
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..253 2/11 (18%)
zf-C2H2_4 261..283 CDD:464025 6/21 (29%)
C2H2 Zn finger 263..283 CDD:275368 6/19 (32%)
zf-H2C2_2 275..300 CDD:463886 12/24 (50%)
C2H2 Zn finger 291..311 CDD:275368 6/19 (32%)
C2H2 Zn finger 319..339 CDD:275368 8/19 (42%)
zf-H2C2_2 331..356 CDD:463886 9/24 (38%)
C2H2 Zn finger 347..366 CDD:275368 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..427
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 638..660
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 778..817
Blue background indicates that the domain is not in the aligned region.

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