Protein Alignment prg and ZNF721

DIOPT Version :10

• Sequence 1: NP_609232.2
• Gene: prg / 34177
• FlyBaseID: FBgn0285971
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_597731.2
• Gene: ZNF721 / 170960
• HGNCID: 29425
• Length: 923
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 108/483 - (22%)
• Similarity: 193/483 - (39%)
• Gaps: 86/483 - (17%)

  Fly    34 DTVQF---CKDVSIAEVSKSLWSVQYDRNECLSE-----LICSRCLEILEEAFELRKGMQ----E 86
            |.:|.   ||.:::.:|.|.:::   ..|:|||.     ..|:..:::..:.....|...    |
Human    45 DNLQLRKGCKSMNVCKVQKGVYN---GINKCLSNTQSKIFQCNARVKVFSKFANSNKDKTRHTGE 106

  Fly    87 REQSLQEQLKEMIK--DHPKHRPGLNGNPGVFVPEE-----GCIIVEVDPENLAESSEEEFALGS 144
            :.....|..|...|  |..:|: |::.....:..||     |. ..:::......:.|:.:....
Human   107 KHFKCNECGKSFQKFSDLTQHK-GIHAGEKPYTCEERGKDFGW-YTDLNQHKKIHTGEKPYKCEE 169

  Fly   145 DGEYENYDDDDEEEEEDYDEEDEEDGQNGEDVDMPLGMDAAQMAAQQSVANNANT-----TEARP 204
            .|:..|...:....:..:   :.|....|||.|...|.           :.|.|.     |..:|
Human   170 CGKAFNRSTNLTAHKRIH---NREKAYTGEDRDRAFGW-----------STNLNEYKKIHTGDKP 220

  Fly   205 KRAFLCQYCDLGFTLPAECQEHELAAHDPNAPYCCNFCNIKLVTRPALISHIKTLHDPDRPYVCA 269
               :.|:.|...|...:...:|| ..|....||.|..|. |:::..:..:..|.:|..::|:.|.
Human   221 ---YKCKECGKAFMHSSHLNKHE-KIHTGEKPYKCKECG-KVISSSSSFAKHKRIHTGEKPFKCL 280

  Fly   270 HCRKGFVRRSDLKKHTIVHTGVRPFTCNVCSKSFSRNTNLTKHMRIHSGVKPFVCQQCPRSFQTA 334
            .|.|.|...:.|.||..:|||.:|:||.||.|:|.::.||..|.|||:|.||:.|.:|.::|:.:
Human   281 ECGKAFNISTTLTKHRRIHTGEKPYTCEVCGKAFRQSANLYVHRRIHTGEKPYTCGECGKTFRQS 345

  Fly   335 VEMMRHTRSHGEVKAFQCGRCPYSFSRRDKLIAHQQVHTRRDMEQQQQMGLIPPMEGDLQQQALQ 399
            ..:..|.|.|...|.::|..|..:|.|...|..|:::||
Human   346 ANLYVHRRIHTGEKPYKCEDCGKAFGRYTALNQHKKIHT-------------------------- 384

  Fly   400 AKQKAAAQTKNSRYYHCDVCDRTFQRERDLQRHQALH-MDSLFACKTCNQGFNRREQLQRH-ELE 462
                      ..:.|.|:.|.:.|....:|..|:.:| .:..:.|:...:.|.....|..: ::.
Human   385 ----------GEKPYKCEECGKAFNSSTNLTAHKRIHTREKPYTCEDRGRAFGLSTNLNEYKKIH 439

  Fly   463 AHGPSFTCGICCISFLHQIELENHLKVH 490
            .....:.|..|..:|:|.:.|..|.|:|
Human   440 TGDKPYKCKECGKAFIHSLHLNKHEKIH 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prg	NP_609232.2	zf-AD	16..94	CDD:462262	13/71 (18%)
		COG5048	<212..340	CDD:227381	42/127 (33%)
		C2H2 Zn finger	239..260	CDD:275368	4/20 (20%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		C2H2 Zn finger	416..436	CDD:275368	5/19 (26%)
		C2H2 Zn finger	443..464	CDD:275368	3/21 (14%)
		C2H2 Zn finger	470..490	CDD:275368	7/19 (37%)
ZNF721	NP_597731.2	C2H2 Zn finger	111..131	CDD:275368	6/20 (30%)
		C2H2 Zn finger	139..159	CDD:275368	3/20 (15%)
		zf-H2C2_2	151..176	CDD:463886	2/24 (8%)
		SFP1	<161..241	CDD:227516	18/97 (19%)
		C2H2 Zn finger	167..187	CDD:275368	2/19 (11%)
		COG5048	218..608	CDD:227381	74/291 (25%)
		C2H2 Zn finger	223..243	CDD:275368	5/20 (25%)
		C2H2 Zn finger	251..271	CDD:275368	4/20 (20%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		COG5048	442..885	CDD:227381	8/26 (31%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368
		C2H2 Zn finger	503..523	CDD:275368
		C2H2 Zn finger	531..551	CDD:275368
		C2H2 Zn finger	559..579	CDD:275368
		C2H2 Zn finger	587..607	CDD:275368
		C2H2 Zn finger	615..634	CDD:275368
		C2H2 Zn finger	643..663	CDD:275368
		C2H2 Zn finger	671..691	CDD:275368
		C2H2 Zn finger	699..719	CDD:275368
		C2H2 Zn finger	755..775	CDD:275368
		C2H2 Zn finger	783..803	CDD:275368
		C2H2 Zn finger	811..831	CDD:275368
		C2H2 Zn finger	839..859	CDD:275368
		C2H2 Zn finger	867..887	CDD:275368
		C2H2 Zn finger	895..915	CDD:275368