Protein Alignment prg and ZNF836

DIOPT Version :10

• Sequence 1: NP_609232.2
• Gene: prg / 34177
• FlyBaseID: FBgn0285971
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_001096127.1
• Gene: ZNF836 / 162962
• HGNCID: 34333
• Length: 936
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 138/516 - (26%)
• Similarity: 221/516 - (42%)
• Gaps: 85/516 - (16%)

  Fly    29 LNIFDDTVQFCKD--VSIAEVSKSL-WSVQYD--RN--------ECLSELI-----------CS- 68
            |...|..::|.::  .|:..|.|:| |.|..:  ||        :|:::.:           |.
Human     8 LTFRDVAIEFSQEEWKSLDPVQKALYWDVMLENYRNLVFLGILPKCMTKELPPIGNSNTGEKCQT 72

  Fly    69 ------RCLEILEEAFELRKGMQEREQSLQEQLKE---MIKDHP-KHRPGLNGNPGVFVPEEGCI 123
                  .|.::  |.|.||: :|:..|.|:.|.|:   ..|:.| .::..|||..|....|
Human    73 VTLERHECYDV--ENFYLRE-IQKNLQDLEFQWKDGEINYKEVPMTYKNNLNGKRGQHSQE---- 130

  Fly   124 IVEVDPENLAESSEEEFALGSDG---EYENYDDDDEEEEEDYDEEDEEDGQNGEDVDMPLGMDAA 185
                |.||  :..|.:..|....   |.:.:    :.|.:.|:....|...|...:..||.....
Human   131 ----DVEN--KCIENQLTLSFQSRLTELQKF----QTEGKIYECNQSEKTVNNSSLVSPLQRILP 185

  Fly   186 QMAA-----------QQSVANNANTTEARPKRAFLCQYCDLGFTLPAECQEHELAAHDPNAPYCC 239
            .:..           |.|:......|..|.| .::|:.|...|.:.:....|:: .|....||.|
Human   186 SVQTNISKKYENEFLQLSLPTQLEKTHIREK-PYMCKGCGKAFRVSSSLINHQM-VHTTEKPYKC 248

  Fly   240 NFCNIKLVTRPALISHIKTLHDPDRPYVCAHCRKGFVRRSDLKKHTIVHTGVRPFTCNVCSKSFS 304
            |.|. |...|.:|::..:.:|...:||.|..|.|.|.:.|||..|...|||.:|:.||.|.||||
Human   249 NECG-KAFHRGSLLTIHQIVHTRGKPYQCGVCGKIFRQNSDLVNHRRSHTGEKPYKCNECGKSFS 312

  Fly   305 RNTNLTKHMRIHSGVKPFVCQQCPRSFQTAVEMMRHTRSHGEVKAFQCGRCPYSFSRRDKLIAHQ 369
            ::.||..|.|||:|.||:.|.:|.::|:....:..|...|...|.:||..|...|.:...|:.||
Human   313 QSYNLAIHQRIHTGEKPYKCNECGKTFKQGSCLTTHQIIHTGEKPYQCDICGKVFRQNSNLVNHQ 377

  Fly   370 QVHTRRDMEQQQQMGLIPPMEGDLQQQAL-QAKQKAAAQTKNS--RYYHCDVCDRTFQRERDLQR 431
            ::||..           .|.:.::..::. |:...|..||.:|  :.|.||.|.:||:|...|..
Human   378 RIHTGE-----------KPYKCNICGKSFSQSSNLATHQTVHSGNKPYKCDECGKTFKRSSSLTT 431

  Fly   432 HQALHM-DSLFACKTCNQGFNRREQLQRHELEAHGPS-FTCGICCISFLHQIELENHLKVH 490
            ||.:|. :..:.|..|::.|::|.||.||:....|.. :.|..|...|.....|..|.::|
Human   432 HQIIHTGEKPYTCDVCDKVFSQRSQLARHQRSHTGEKPYKCNECGKVFSQTSHLVGHRRIH 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prg	NP_609232.2	zf-AD	16..94	CDD:462262	21/95 (22%)
		COG5048	<212..340	CDD:227381	46/127 (36%)
		C2H2 Zn finger	239..260	CDD:275368	6/20 (30%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		C2H2 Zn finger	296..316	CDD:275368	11/19 (58%)
		C2H2 Zn finger	324..344	CDD:275368	4/19 (21%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		C2H2 Zn finger	416..436	CDD:275368	9/19 (47%)
		C2H2 Zn finger	443..464	CDD:275368	8/20 (40%)
		C2H2 Zn finger	470..490	CDD:275368	5/19 (26%)
ZNF836	NP_001096127.1	KRAB	7..48	CDD:460171	11/39 (28%)
		SFP1	<215..297	CDD:227516	25/84 (30%)
		C2H2 Zn finger	220..240	CDD:275368	4/20 (20%)
		C2H2 Zn finger	248..268	CDD:275368	6/20 (30%)
		COG5048	272..648	CDD:227381	77/232 (33%)
		C2H2 Zn finger	276..296	CDD:275368	8/19 (42%)
		C2H2 Zn finger	304..324	CDD:275368	11/19 (58%)
		C2H2 Zn finger	332..352	CDD:275368	4/19 (21%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	388..408	CDD:275368	4/19 (21%)
		C2H2 Zn finger	416..436	CDD:275368	9/19 (47%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		C2H2 Zn finger	472..492	CDD:275368	5/19 (26%)
		COG5048	496..904	CDD:227381
		C2H2 Zn finger	500..520	CDD:275368
		C2H2 Zn finger	528..548	CDD:275368
		C2H2 Zn finger	556..576	CDD:275368
		C2H2 Zn finger	584..604	CDD:275368
		C2H2 Zn finger	612..632	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		C2H2 Zn finger	668..688	CDD:275368
		C2H2 Zn finger	696..714	CDD:275370
		C2H2 Zn finger	724..744	CDD:275368
		C2H2 Zn finger	752..772	CDD:275368
		C2H2 Zn finger	780..800	CDD:275368
		C2H2 Zn finger	808..828	CDD:275368
		C2H2 Zn finger	836..856	CDD:275368
		C2H2 Zn finger	864..884	CDD:275368
		C2H2 Zn finger	892..912	CDD:275368