DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aasdh and aasdh

DIOPT Version :9

Sequence 1:	NP_609230.2	Gene:	Aasdh / 34175	FlyBaseID:	FBgn0027780	Length:	1012	Species:	Drosophila melanogaster
Sequence 2:	XP_698902.3	Gene:	aasdh / 570338	ZFINID:	ZDB-GENE-041210-322	Length:	1152	Species:	Danio rerio

Alignment Length:	1160	Identity:	295/1160 - (25%)
Similarity:	465/1160 - (40%)	Gaps:	274/1160 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 DEAGIALRVT--EHTPASSLM----------ILAILNNKCHFFPTDKMMLSQDLYSQMSTAGVDY 120
            ||....|||:  .|..|..|.          |:.||.....:.|.|.....|.....::...:.:
Zfish    45 DELTAQLRVSVQNHEGAIGLFCHPDVLLPVWIIGILQFPAAYLPLDPASPPQCSLRMINNCRLSF 109

  Fly   121 -LVANKHLTVAPLYFTFLGSILVFKEDC--RLYRVKLKS----------------ADETVQSKKP 166
             |:.|:.|......|:.|.|:.|....|  ||..:|:||                ..:.:|..:|
Zfish   110 CLIQNELLHQFQSAFSILISVEVCATFCSHRLTLIKIKSEQKENSQANDAPFSSAVTKNIQQGEP 174

  Fly   167 LPANMCYTISTTGTTGKPKLIHVPYECIAPNIVGLSQKLNVSMADIIYLGTPITFDPFVVEFFLA 231
            |    .|.:.|:||||.||::.||:.||.|||:.|.....::..|:::|.:|:||||.|||.|||
Zfish   175 L----AYILHTSGTTGLPKIVKVPHRCIVPNIIHLRSVFKMTPEDVVFLSSPLTFDPSVVEVFLA 235

  Fly   232 LQNGATLLTSRHSMRDSPSKVLSALFPDNLATPGITVLQMTPSLFRQFGASSIKDRVLSGSSSLR 296
            |.:||.||....:::..|.::...||..|..    ||||.||:|.|:||...:::.|||..||||
Zfish   236 LSSGACLLIVPSAVKKMPRRLAHVLFKRNTT----TVLQATPTLVRRFGKVVLQEEVLSADSSLR 296

  Fly   297 VLLLGGEPFPSNVELVTWMHPSVLMQKHICNIYGITEISCWSLLHIVQS--------LQSPVPLG 353
            :|..||||.||...:.:|....  .:.||.|:||.||:|||:..:.|..        ..:|||||
Zfish   297 ILAFGGEPCPSLNLVKSWRQEG--NRTHIYNLYGTTEVSCWASWYKVPDEHLCLEDITDAPVPLG 359

  Fly   354 TPIEEDTVLRIESEDNE--TSQQGELFLGSVKRRCYIPEVDDQANASQDDSGICFRATGDLVTRQ 416
            .|: .|||:.:..|...  |..:|:||:|...|.|.:   ||:....:.    ..|||||.| :.
Zfish   360 EPM-LDTVMEVRDETGHLVTEGEGQLFIGGQNRVCLL---DDEETVVKG----TMRATGDWV-QV 415

  Fly   417 QDGTLFYSERSNDVVKRAGNRISLGLITRKIQK------CLP----------------------- 452
            |:..|::..|.:.:|||.|.|:.|..:.:.|:.      |..
Zfish   416 QNSNLYFLGRKDRLVKRFGQRVHLDALQQMIESFSGVEACAVNLSKDDRLLAFIVLTSGHAGAPL 480

  Fly   453 SSELTTCLWLEDLQKLICCI---------RTLESKTRVQQRVQTFDILSK-VSIAEQPDRFVYLQ 507
            |||:.....|....::...:         |..|.:.|.|        ||| :|....||..|::.
Zfish   481 SSEIHHDKHLTQPSEISVSVSPKASPPSLRVTEGEIRHQ--------LSKRLSSHSIPDMMVFIP 537

  Fly   508 HFPCNVHGKLDKQQLLKMCIPLAQP--AQQILKSYLHDRL-------ECVEEPDDSASKKQRLDD 563
            ..|...|||:...:|:|.|....|.  .|...|.....||       ||:...||...::
Zfish   538 ALPLTSHGKIAIDELMKTCETQRQDKNKQAPQKDTASVRLKLQNLWKECLGLQDDVVVEE----- 597

  Fly   564 AAPCGYDLSFRQAGGTSFHAITICREIG----------LQMCIDDEQRHLFEMLLDEN------- 611
                  :..|..:||.|..|:.:..:|.          |::.:|.....|...::.|.
Zfish   598 ------NAHFMFSGGDSLQALRLFDDITVAMGTTSVGLLEVILDGSFSDLLSHIMTETHDDAVLP 656

  Fly   612 ---------------------------------IP-LRTVLRFL--------------------- 621
                                             :| ||..:.|:
Zfish   657 SKKRTADYSDSEASGKRQHKEMTTSSDTESPFVVPSLRRTMGFVVVRRAAEVFKWGFQKIPQGIF 721

  Fly   622 ----------------DTAKLVANNIKRKNVETAVV-----VSACQSGLIIKRIEQP-------- 657
                            ||. |::|.....:..:||.     :.|.:..|:..  |.|
Zfish   722 SDAPDKNYVTNNSVGNDTG-LISNPSLELSKSSAVTNMADHLQAQEETLLAS--ESPSSHGGVRE 783

  Fly   658 ------VLKLQIYWKVNFEKCID-SP--VTEYEGRFICVGAHSKILRTLNPQTGSEYSVVKLPER 713
                  .|.|::.|:.:..:|:| ||  :...:...:.:|:||..|:.|:...|.......|.:|
Zfish   784 DSTGVLPLALRVLWRSDTGRCVDASPMLLVAPDRTTVFIGSHSHRLQALDLSRGEVIWERILGDR 848

  Fly   714 IECKVTFLT-EQLAMVGCYDGCLYGFNPQTGNIVFRVGIGGLIKSQPMLTADGRRIIVCSYADDY 777
            :|......: ..|..:||||..:|..:...|:.|:....|.::||.|  |.|.:..:|.:.:.|.
Zfish   849 LESSAAISSCGGLVAIGCYDRQMYFLDVSCGDTVWTFETGDVVKSSP--TVDPKTGLVFAGSHDG 911

  Fly   778 NVYCLSAERQEVLWCLRIGEKPIFASPLELPREQSLIVCTLDGSYSRVAITDGSVEWTQKFREPV 842
            :||.|:...:...|....|...:|:||......:.|...:|.|....:....|.|.|......|.
Zfish   912 HVYALNPLTKTCTWQHYCGGGAVFSSPCVHLSPRQLYCSSLGGHLHCLNPDSGKVLWKYSSSAPF 976

  Fly   843 FSTPVLLESVSNIFLSAEVAGRVHACHVGNGKILATFSTEGNIFSS-------LVVKTPP----- 895
            ||:|..  |.|::|:.:.....:...|.||  .|..|||:|.:|||       |:...||
Zfish   977 FSSPHC--SDSSVFIGSVNGHIIGISHSGN--TLWDFSTDGPVFSSPCISSLTLLTNQPPSTTPS 1037

  Fly   896 ---TFMGHSFAIFGCIDQHLYCLRCKTGPGGKSVELELHWKVDVGAPIYATPTLLTVQPNGL--L 955
               |...:.....|..|.|:|||..:.|        .|.|:......:::||.:.:....||  |
Zfish  1038 SSVTTSPNHIVTCGSHDGHVYCLNAQNG--------SLLWQFQTTGKVFSTPFVFSGALWGLRTL 1094

  Fly   956 VWCAATDGRVMLINFRNGEIQWSDKLPGQVFSSACFIEDLRRVFVGCRDNFLYCL 1010
            ....:|||:|.:::...|..:.:..|||::|||......  ::.||||::::|||
Zfish  1095 AAVCSTDGKVWVLDGETGIQKATLSLPGELFSSPVIWGS--KLVVGCRNDYVYCL 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aasdh	NP_609230.2	AA-adenyl-dom	46..443	CDD:273779	138/415 (33%)
		AFD_class_I	<168..522	CDD:302604	129/402 (32%)
		PQQ_DH_like	<728..1012	CDD:299747	83/300 (28%)
		PQQ_2	732..978	CDD:290097	67/262 (26%)
aasdh	XP_698902.3	AFD_class_I	22..547	CDD:302604	158/528 (30%)
		AA-adenyl-dom	36..457	CDD:273779	140/430 (33%)
		PQQ_DH_like	794..1147	CDD:299747	96/368 (26%)
		PQQ_2	794..1007	CDD:290097	54/218 (25%)
		WD40 repeat	851..886	CDD:293791	8/34 (24%)
		WD40 repeat	893..936	CDD:293791	11/44 (25%)
		PQQ_2	909..1151	CDD:290097	69/253 (27%)
		WD40 repeat	949..1017	CDD:293791	20/71 (28%)
		WD40 repeat	1024..1076	CDD:293791	13/59 (22%)
		WD40 repeat	1083..1106	CDD:293791	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595894
Domainoid	1	1.000	180	1.000	Domainoid score	I3472
eggNOG	1	0.900	-	-		E1_COG1020
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71711
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3620
OMA	1	1.010	-	-		QHG60259
OrthoDB	1	1.010	-	-		D424682at33208
OrthoFinder	1	1.000	-	-		FOG0002418
OrthoInspector	1	1.000	-	-		oto40783
orthoMCL	1	0.900	-	-		OOG6_100454
Panther	1	1.100	-	-	LDO	PTHR44394
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5888
SonicParanoid	1	1.000	-	-		X5394
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800