DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aasdh and Aasdh

DIOPT Version :9

Sequence 1:	NP_609230.2	Gene:	Aasdh / 34175	FlyBaseID:	FBgn0027780	Length:	1012	Species:	Drosophila melanogaster
Sequence 2:	XP_038948856.1	Gene:	Aasdh / 364136	RGDID:	1311135	Length:	1099	Species:	Rattus norvegicus

Alignment Length:	1128	Identity:	303/1128 - (26%)
Similarity:	483/1128 - (42%)	Gaps:	271/1128 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LRKNGVPDEAGIALRVTEHTPASSLMILAILNNKCHFFPTDKMMLSQDLYSQMSTAGVDYLVANK 125
            :|:.|:..:.||.|      |:   .||.||.....:.|.|...|.......|...|:.|::..|
  Rat    58 IREIGLYCQPGINL------PS---WILGILQIPAAYAPIDPDSLPSLATHFMKKCGLKYVLVEK 113

  Fly   126 ---------HLTVAPLYFTF------------------LGSILVFKEDCRLYRVKLKSADETV-- 161
                     |.||.. |.|.                  :.|:|..:.|    :.|:...:|.|
  Rat   114 RQITKFKSSHETVLN-YDTVSVEHKDLVLLRLHWEDGAVNSVLSDRTD----KCKVNDREERVNG 173

  Fly   162 ----QSKKPLPAN----MCYTISTTGTTGKPKLIHVPYECIAPNIVGLSQKLNVSMADIIYLGTP 218
                |.|..:...    :.|.:.|:||||.||::.||:.||.|||.......:::..|:::|.:|
  Rat   174 ENGSQEKGHMDMRREGCLAYVLHTSGTTGTPKIVRVPHACILPNIQHFRSLFDITQEDVLFLASP 238

  Fly   219 ITFDPFVVEFFLALQNGATLLTSRHSMRDSPSKVLSALFPDNLATPGITVLQMTPSLFRQFGASS 283
            :||||.|||.|:||.:||.||.|..|::..|||:...||    :...:||||.||:|.|:||:..
  Rat   239 LTFDPSVVEIFVALSSGACLLISPTSVKVLPSKLADVLF----SRHRVTVLQATPTLLRRFGSEL 299

  Fly   284 IKDRVLSGSSSLRVLLLGGEPFPSNVELVTWMHPSVLMQKHICNIYGITEISCWSLLH-----IV 343
            :|..|||..:|||||.||||.|||...|.:|...|...|  |.|||||||:|.|:..:     |:
  Rat   300 MKSTVLSAHTSLRVLALGGEAFPSLTVLQSWRGKSNRTQ--IFNIYGITEVSSWATFYRIPEEIL 362

  Fly   344 QS---LQSPVPLGTPIEEDTVLRIESEDNETSQQ--GELFLGSVKRRCYIPEVDDQANASQDDSG 403
            .|   |:|||.||:|: ..||:.:..::.....:  |::|||...|.|::   |::......
  Rat   363 NSSVRLESPVQLGSPL-LGTVVEVRDKNGSPVHEGTGQVFLGGKNRICFL---DEEMTVPLG--- 420

  Fly   404 ICFRATGDLVTRQQDGTLFYSERSNDVVKRAGNRISLGLITRKIQKCLPSSELTTCLWLEDLQKL 468
             ..|||||.|| .:.|.:|:..|.:..:||.|.|:|:.|:.:.               .|:|:::
  Rat   421 -TMRATGDFVT-VKGGEIFFLGRKDSQIKRHGKRLSIALVQQV---------------AEELRQV 468

  Fly   469 ICCIRTLESKTRVQQRVQTFDILSKVSIAEQ---------------PDRFVYLQHFPCNVHGKLD 518
            ..|..|..:    |:::..| |:|||.:.:.               ||..|.:...|...|||:|
  Rat   469 ESCAVTWYN----QEKLILF-IVSKVDLVKDYIFKELQKHLPAHALPDDMVLIGSLPVTCHGKVD 528

  Fly   519 KQQLLKMCIPL--AQPAQQIL-KSYLHDRLECVEE-----PDDSASKKQRLDDAAPCGYDLSFRQ 575
            ..:|.|:.:..  :||..::. |..|..:|:|:.:     |:|...|..  |::.       |..
  Rat   529 VSELNKIYLDYISSQPRNKLHGKEELWGKLQCLWKSILCLPEDPELKVP--DNSV-------FLD 584

  Fly   576 AGGTSFHAITICREIG----------LQMCID----DEQRHLFEMLLD-ENIP----LRTVLRFL 621
            :||.|..::.:..|:.          |::.:.    |...|:.:.:|. |::.    ..|..:|.
  Rat   585 SGGDSLKSLWLLGEVEKLTGAPVPGLLEVILSSSFLDVYNHIIQAVLTREDLKGDRRYTTKRKFS 649

  Fly   622 D---------TAKLVANNIKRKNVETAVVVS--------------------ACQSGL-------- 649
            |         .|:|.|.....::.||..||:                    .|.:.:
  Rat   650 DPDSEETSGKPARLEAAWPWHRDSETNSVVALSRGSQTLYLGTGRLLTELGLCPNAVHPPDLIPQ 714

  Fly   650 ----IIKRIEQPVLK----------------------LQIYWKVNFEKCID-SP------VTEYE 681
                |:|.:..|.|.                      |:..|:.:..||:| ||      |.:..
  Rat   715 TNTEILKSLSPPALDETLEKPPLSQERSPGTGAEPMVLRERWRSDTGKCVDASPLLVVAAVGDTS 779

  Fly   682 GRFICVGAHSKILRTLNPQTGSEYSVVKLPERIECKV------TFLTEQLAMVGCYDGCLYGFNP 740
            ...:.:|:||..::.::..:|......::.:|||...      .|:     :||||||.:|....
  Rat   780 STTVYIGSHSHTVKAVDLHSGEMRWERRVGDRIESSACVSKCGNFI-----VVGCYDGLVYVLKS 839

  Fly   741 QTGNIVFRVGIGGLIKSQPMLTADGRRIIVCSYADDYNVYCLSAERQEVLWCLRIGEKPIFASPL 805
            .:|...:.......:||.|.:......|.|.|:  |.:.|.|....::.:|.|:. |..:|:||.
  Rat   840 NSGEKHWTFPTEDAVKSSPAVDPTTGLIYVGSH--DQHAYALDIYEKKCVWKLKC-EGALFSSPC 901

  Fly   806 ELPREQSLIVCTLDGSYSRVAITDGSVEWTQKFREPVFSTP------VLLESVSNIFLSAEVAGR 864
            .......|...||.|....|....||:.|.:...:|:||:|      |.:..|....|
  Rat   902 LSLGPHHLYCATLGGLLLAVNPATGSLIWKRPCGKPLFSSPRCYQHYVCIGCVDGSLL------- 959

  Fly   865 VHACHVGNGKILATFSTEGNIFSSLVVKTPPTFMGHSFAIFGCIDQHLYCLRCKTGPGGKSVELE 929
               |...:|:.:..||..|.||||     |..........||..|..|||  |.|..|
  Rat   960 ---CFSHSGEQVWRFSAGGPIFSS-----PCISASEQDIYFGSHDCFLYC--CSTEGG------- 1007

  Fly   930 LHWKVDVGAPIYATPTLLTVQPN-----GLLVWCAATDGRVMLINFRNGEIQWSDKLPGQVFSSA 989
            |.||.:..|.:|:||...   ||     |.|:..|:|||::.::..::||::...:|||:||||.
  Rat  1008 LRWKFETTARVYSTPFAF---PNHLCGSGTLLAAASTDGKLWVLESQSGELRSVYELPGEVFSSP 1069

  Fly   990 CFIEDLRRVFVGCRDNFLYCLGI 1012
            ...|.:  :.:|||:|::|||.:
  Rat  1070 VVWESM--LVIGCRNNYIYCLDL 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aasdh	NP_609230.2	AA-adenyl-dom	46..443	CDD:273779	142/428 (33%)
		AFD_class_I	<168..522	CDD:302604	131/382 (34%)
		PQQ_DH_like	<728..1012	CDD:299747	89/294 (30%)
		PQQ_2	732..978	CDD:290097	70/256 (27%)
Aasdh	XP_038948856.1	A_NRPS_acs4	16..532	CDD:341309	165/537 (31%)
		WD40 repeat	751..786	CDD:293791	9/34 (26%)
		PQQ	753..1048	CDD:224437	81/268 (30%)
		WD40 repeat	793..847	CDD:293791	17/59 (29%)
		WD40 repeat	854..898	CDD:293791	11/43 (26%)
		WD40 repeat	906..932	CDD:293791	10/25 (40%)
		PQQ_3	1059..1091	CDD:404459

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353745
Domainoid	1	1.000	176	1.000	Domainoid score	I3528
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71711
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3243
OMA	1	1.010	-	-		QHG60259
OrthoDB	1	1.010	-	-		D424682at33208
OrthoFinder	1	1.000	-	-		FOG0002418
OrthoInspector	1	1.000	-	-		oto96550
orthoMCL	1	0.900	-	-		OOG6_100454
Panther	1	1.100	-	-	LDO	PTHR44394
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5394
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910