Protein Alignment Aasdh and Aasdh

DIOPT Version :10

• Sequence 1: NP_609230.2
• Gene: Aasdh / 34175
• FlyBaseID: FBgn0027780
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_776126.1
• Gene: Aasdh / 231326
• MGIID: 2442517
• Length: 1100
• Species: Mus musculus
• Alignment Length: 1178
• Identity: 297/1178 - (25%)
• Similarity: 482/1178 - (40%)
• Gaps: 294/1178 - (24%)

  Fly    15 QPDKLYNINRIRAFKDVPFLIRRTESKDTIVSYADAADEIQVLMNFLRKNGVPDEAGIALRVTEH 79
            ||...|:...:        |...:|....::::.|        ...:|:.|:..:.||.|
Mouse    28 QPPVCYSYKAL--------LSAASELSHFLIAHCD--------FGGIREIGLYCQPGINL----- 71

  Fly    80 TPASSLMILAILNNKCHFFPTD-----------------------KMMLSQDLYSQMSTAGVDYL 121
             |:   .||.||.....:.|.|                       |..||:...|..:....|.:
Mouse    72 -PS---WILGILQVPAAYAPIDPDSPPSLSTYFMKKCDLKYVLVEKQQLSKFKSSHETVLNYDTV 132

  Fly   122 -VANKHLTVAPLYFTFLGSILVFKEDCRLYRVKLKSADE----------TVQSKKPLPANM---- 171
             |.:|.|.:..|::          ||.|:..|....||:          :.:|:.|...:|
Mouse   133 SVEHKDLALFRLHW----------EDGRVSTVLGDRADQHKVTDREDRVSAESRTPEKEHMDMRH 187

  Fly   172 ----CYTISTTGTTGKPKLIHVPYECIAPNIVGLSQKLNVSMADIIYLGTPITFDPFVVEFFLAL 232
                .|.:.|:||||.||::.||:.||.|||.......:::..||::|.:|:||||.|||.|::|
Mouse   188 DGCLAYVLHTSGTTGTPKIVRVPHACILPNIQHFRSLFDITQEDILFLASPLTFDPSVVEIFVSL 252

  Fly   233 QNGATLLTSRHSMRDSPSKVLSALFPDNLATPGITVLQMTPSLFRQFGASSIKDRVLSGSSSLRV 297
            .:||.||....|::..|||:...||    :...:||||.||:|.|:||:..||..|||..:||||
Mouse   253 SSGACLLIVPTSVKVLPSKLADILF----SRHRVTVLQATPTLLRRFGSELIKSTVLSAHTSLRV 313

  Fly   298 LLLGGEPFPSNVELVTWMHPSVLMQKHICNIYGITEISCWS--------LLHIVQSLQSPVPLGT 354
            |.||||.|||...|.:|.......|  |.|||||||:|.|:        :|:.....:|||.||:
Mouse   314 LALGGEAFPSLTILKSWRGKGNRTQ--IFNIYGITEVSSWATFYRIPEEILNSAVKHESPVQLGS 376

  Fly   355 PIEEDTVLRIESEDNETSQQ--GELFLGSVKRRCYIPEVDDQANASQDDSGICFRATGDLVTRQQ 417
            |: ..||:.:..::.....:  |::|||...|.|::   ||:......    ..|||||.|| .:
Mouse   377 PL-LGTVIEVRDQNGSPVLEGTGQVFLGGKNRVCFL---DDEMTVPLG----TMRATGDFVT-VK 432

  Fly   418 DGTLFYSERSNDVVKRAGNRISLGLITRKIQKCLPSSELTTCLWLEDLQKLICCIRTLESKTRVQ 482
            ||.:|:..|.:..:||.|.|:::.|:.:.               .|:|:::..|..|..:    |
Mouse   433 DGEIFFLGRKDSQIKRHGKRLNIALVQQV---------------AEELRQVESCAVTWYN----Q 478

  Fly   483 QRVQTFDILSKVSIAEQ---------------PDRFVYLQHFPCNVHGKLDKQQLLKMCIPL--A 530
            :|:..| |:|||.:.:.               ||..|.:...|...|||:|..:|.|:.:..  :
Mouse   479 ERLILF-IVSKVDLVKDCIFKELQKHLPAHALPDDMVLIDTLPFTCHGKVDVSELNKIYLDYISS 542

  Fly   531 QPAQQI--------LKSYLHDRLECV-EEPDDSASKKQRLDDAAPCGYDLSFRQAGGTSFHAITI 586
            ||..::        ...||...:.|: |:|:|:..        .|.  :..|..:||.|..::.:
Mouse   543 QPRNELHGKEELWGKLQYLWKSILCLPEDPEDTLK--------VPA--NSVFLDSGGDSLKSMRL 597

  Fly   587 CREIG--------------LQMCIDDEQRHLFEMLL-----DENIPLRTVLRFLDT--------- 623
            ..||.              |...:.|...|:.:.:.     ..|....|..:|.|.
Mouse   598 LSEIERLTGTAIPGLLEVILSSSLLDVYNHIVQAVFTPEDRKANRSYTTKRKFSDADPEEASGKP 662

  Fly   624 ------------------------AKLVANNIKRKNVETAVVVSACQSGL-------IIKRIEQP 657
                                    :::::....|...:..:.:..|...|       |:|.:..|
Mouse   663 ARLESAWPSNHAGETNSVIALSRGSQVLSLGAGRLLTQLGLCLPVCSLDLIPQTNTQILKSLSPP 727

  Fly   658 ----------------------VLKLQIYWKVNFEKCID-SP------VTEYEGRFICVGAHSKI 693
                                  .:.|:..|:.:..||:| ||      |.:.....:.:|:||..
Mouse   728 APDENLEKPPLFQQGSPVVGAMAMALRERWRSDTGKCVDASPLLVRAAVQDKPSTTVYIGSHSHT 792

  Fly   694 LRTLNPQTGSEYSVVKLPERIECKV------TFLTEQLAMVGCYDGCLYGFNPQTGNIVFRVGIG 752
            ::.::..:|.......|.:|||...      .|:     :||||:|.:|.....:|...:.....
Mouse   793 VKAVDLSSGETRWEQLLGDRIESSACVSKCGNFI-----VVGCYNGLVYVLKSNSGEKYWTFTTE 852

  Fly   753 GLIKSQPMLTADGRRIIVCSYADDYNVYCLSAERQEVLWCLRIGEKPIFASPLELPREQSLIVCT 817
            ..:||.|.:......|.|.|:  |.:.|.|....::.:|.|.. |..:|:||........|...|
Mouse   853 DAVKSSPAVDPTTGLIYVGSH--DQHAYALDIYEKKCVWKLNC-EGALFSSPCVSLSPHHLYCAT 914

  Fly   818 LDGSYSRVAITDGSVEWTQKFREPVFSTP------VLLESVSNIFLSAEVAGRVHACHVGNGKIL 876
            |.|....:....||..|.:...:|:||:|      :.:..|....|          |...:|:.:
Mouse   915 LGGLLLALNPASGSTVWKRSCGKPLFSSPRCYQQYICIGCVDGSLL----------CFTHSGEQV 969

  Fly   877 ATFSTEGNIFSSLVVKTPPTFMGHSFAIFGCIDQHLYCLRCKTGPGGKSVELELHWKVDVGAPIY 941
            ..|:..|.||||     |..........||..|..:||  |       |.|..|.||.:..|.:|
Mouse   970 WRFAAGGPIFSS-----PCVSAAEQEIFFGSHDCFIYC--C-------SKEGHLRWKFETTARVY 1020

  Fly   942 ATPTLLTVQP--NGLLVWCAATDGRVMLINFRNGEIQWSDKLPGQVFSSACFIEDLRRVFVGCRD 1004
            |||...:..|  :..|:..|:|||::.::..|:||::...:|||:||||....|.:  :.:|||:
Mouse  1021 ATPFAFSNHPRSDDALLAAASTDGKLWVLESRSGELRSVYELPGEVFSSPVVWESM--LVIGCRN 1083

  Fly  1005 NFLYCLGI 1012
            |::|||.:
Mouse  1084 NYIYCLDL 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aasdh	NP_609230.2	A_NRPS_acs4	29..522	CDD:341309	163/559 (29%)
		PQQ	656..>791	CDD:441129	34/169 (20%)
		PQQ_2	732..978	CDD:433144	65/253 (26%)
		PQQ_3	973..1010	CDD:463925	15/36 (42%)
Aasdh	NP_776126.1	A_NRPS_acs4	15..532	CDD:341309	165/570 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..181		5/28 (18%)
		PP-binding	561..>610	CDD:425746	11/63 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	643..671		6/56 (11%)
		PQQ	730..>881	CDD:441129	36/162 (22%)
		PQQ_2	792..1012	CDD:433144	63/227 (28%)
		PQQ	<965..>1080	CDD:441129	23/61 (38%)