DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aasdh and nrps-1

DIOPT Version :9

Sequence 1:	NP_609230.2	Gene:	Aasdh / 34175	FlyBaseID:	FBgn0027780	Length:	1012	Species:	Drosophila melanogaster
Sequence 2:	NP_499488.3	Gene:	nrps-1 / 190498	WormBaseID:	WBGene00013440	Length:	2942	Species:	Caenorhabditis elegans

Alignment Length:	940	Identity:	193/940 - (20%)
Similarity:	322/940 - (34%)	Gaps:	292/940 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KDVPFL----------------IRRTESKDTIVSYADAADEIQVLMNFLRKNGVPDEAG------ 71
            ||.|.|                |..|.|| |..:||.|...:....:.|.|..:..:|.
Worm  2194 KDTPNLSIPSIYQQFFTANSTSIFATTSK-TSTTYAQAYRRLSQYSSCLSKKFLTSKAQPIRSDD 2257

  Fly    72 -IALRVTEHTPASSLMILAILNNKCHFFPTD--------KMMLSQDLYSQMSTAGVDYLVANKHL 127
             |::..|..| .:::..||:......:.|.|        |.:|...:::......||....::|.
Worm  2258 VISVAGTRST-ETTMKCLAVQFTGAAYLPIDASYPEERKKTILKDSVFNFEYNGRVDQEPRHRHF 2321

  Fly   128 TVAPLYFTFLGSILVFKEDCRLYRVKLKSADETVQSKKPLPANMCYTISTTGTTGKPKLIHVPYE 192
            .::..|             |                       :.|.|:|:||||.||.:.:..:
Worm  2322 AISTDY-------------C-----------------------LSYIITTSGTTGTPKSVAIGAK 2350

  Fly   193 CIAPNIVGLSQKLNVSMADIIYLGTPITFDPFVVEFFLALQNGATLLTSRHSMRDSPSKVLSALF 257
            .:....:..:..:..|.:...|..|...||..|:|..:::.:..||:.       .|.....|.|
Worm  2351 SLLNLFLSSTLTMKCSSSSRTYQFTNFVFDNSVLEVSMSIASQGTLVY-------GPLCFDPADF 2408

  Fly   258 PDNLATPGITVLQMTPSLFRQFGASSIKDRVLSGSSSLRVLLLGGEPFPSNVELVTWMHPSVLMQ 322
            ..::.|.|||...:.|||.:.|..|.||        :|...::||||.|.::     :..::.:.
Worm  2409 EKSIETEGITHCLLFPSLVQSFNISKIK--------NLAYWVVGGEPLPQSL-----LDSALALG 2460

  Fly   323 KHICNIYGITEISCWSLLHIVQSLQSPVPLGTPIEEDTVLRIESEDNETSQQGELFLGSVK-RRC 386
            ..:...||.||.:.:::...::...:...:|.|.....:..:|.||     ||||.:..:. .|.
Worm  2461 IKVIQNYGPTETTAFAIAKHMKKGDAGCQIGLPAVNSKIRIVEGED-----QGELLISGLGIMRG 2520

  Fly   387 YIPEVDDQANASQDDSGICFRATGDLVTRQQDGTLFYSERSNDVVKRAGNRISLGLITRKIQKCL 451
            |:...:.|..||.|            |.|.:.|.:.:..|::..:|..|.|:.|    .:|:|.:
Worm  2521 YLNRKESQWYASGD------------VCRIEKGVVEFVGRTDTQIKIRGYRVEL----TEIEKTI 2569

  Fly   452 PS-SELTTCLWLED-------------LQKLIC------CIRTLESKTRVQQRVQTFDILSKVSI 496
            .| :.:.:|..|.|             |:||..      |.|.||.              .|:
Worm  2570 ESRNGIASCKALFDKESQQIHVFYTGELEKLSSNDAREHCERYLEP--------------HKI-- 2618

  Fly   497 AEQPDRFVYLQHFPCNVHGKLDKQQLLKMCIPLAQPA-----QQILKSYLHDRLECVE-EPDDSA 555
               |..|..:..||...:.|:|..:|:::...|..|.     :..|.|.....|.|.| .|.|
Worm  2619 ---PSTFNGIDKFPLTGNSKIDTLKLMELVKNLPHPTLPNSLESDLSSIWTSLLNCPEPSPSD-- 2678

  Fly   556 SKKQRLDDAAPCGYDLSFRQAGGTSFHAITICREIGLQMCIDDEQRHLFEMLLDENIPLRTV--- 617
                            .|...||   |::.:.|           .|||.|..|..::.:..:
Worm  2679 ----------------HFFLIGG---HSLLLVR-----------LRHLIETKLGISLKVPEILQN 2713

  Fly   618 LRFLDTAKLVANNIKRKNVETAVVVSACQSGLI--IKRIEQPVLKLQIYWKVNF----EKCIDSP 676
            |:|.|..:|:|.  |::...:.||..|...|.:  .|.:|:  ||.:...|.||    |:..|:
Worm  2714 LKFSDMLELLAK--KKQRAISVVVFPALYGGCLPYHKMVEE--LKKRFLGKTNFILLDEEFGDT- 2773

  Fly   677 VTEYEGRFICVGAHSKILRTLNPQTGSEYSVVKLPERIECKVTFLTEQLAMVGCYDGCLYGFNPQ 741
                      |...:|:.|         ..:.:..|.||      |.:|..:|......:.|
Worm  2774 ----------VDEVAKLYR---------LQIEESAENIE------TSKLVFIGASSAGTFAF--- 2810

  Fly   742 TGNIVFRVGIGGLIKSQPMLTADGRRIIVCSYADDYNVYCLSAERQEVLWCL------RIGEKPI 800
                           |...|.||          ||..|..|..   ...|.|      |..|:.|
Worm  2811 ---------------STSQLFAD----------DDVTVLLLDT---GTFWSLIEKLEFRKHEQEI 2847

  Fly   801 FASPLELPREQSLIVCTLDGSYSRVAI-------------------TDGS-VEWTQKFREPVFST 845
            ..:......:|....|..:.|:..:.|                   .||| :.|: |:.:.:.:.
Worm  2848 VENLKNFGVDQKTSKCLAETSWKTLQILKNYHPEESRSNVQLHVLSVDGSDLGWS-KYSKNLIAH 2911

  Fly   846 PVLLESVSNIFLSAEVAGRVHACHVGNGKI 875
            .:..:..|.:..|..|.|.|       |||
Worm  2912 KIQGDHYSMLQDSEHVLGLV-------GKI 2934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aasdh	NP_609230.2	AA-adenyl-dom	46..443	CDD:273779	85/412 (21%)
		AFD_class_I	<168..522	CDD:302604	85/374 (23%)
		PQQ_DH_like	<728..1012	CDD:299747	32/174 (18%)
		PQQ_2	732..978	CDD:290097	31/170 (18%)
nrps-1	NP_499488.3	Condensation	441..686	CDD:305010
		HxxPF_rpt	712..802	CDD:290463
		AFD_class_I	860..1269	CDD:302604
		AA-adenyl-dom	860..1207	CDD:273779
		PP-binding	1312..1361	CDD:278949
		Condensation	1379..1606	CDD:305010
		PP-binding	1712..1776	CDD:278949
		Condensation	1800..>1941	CDD:305010
		AFD_class_I	2223..2641	CDD:302604	106/514 (21%)
		AA-adenyl-dom	2253..2578	CDD:273779	82/402 (20%)
		PP-binding	2661..2723	CDD:278949	20/93 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1020
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6452
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002418
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100454
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5888
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.650