DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aasdh and pks-1

DIOPT Version :9

Sequence 1:	NP_609230.2	Gene:	Aasdh / 34175	FlyBaseID:	FBgn0027780	Length:	1012	Species:	Drosophila melanogaster
Sequence 2:	NP_508923.2	Gene:	pks-1 / 180815	WormBaseID:	WBGene00016558	Length:	7752	Species:	Caenorhabditis elegans

Alignment Length:	706	Identity:	156/706 - (22%)
Similarity:	268/706 - (37%)	Gaps:	189/706 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KLYNINRIRAFKDVPFLIRRTESKDTI-----------------------VSYADAADEIQVLMN 59
            ||.|:..:..  .:|  ||||:...|:                       |||:|.|::|:.:..
Worm  6953 KLNNLRNMNT--TIP--IRRTDFPSTLFQKGLFTSWRLFTEPALLLSTNTVSYSDLAEKIENISK 7013

  Fly    60 FLRKNGVPDEAGIALRVTEHTPASSLMILAILNNKCHFFPTDKMMLSQDLYSQMSTAGVDYLVAN 124
            .::|.         |::.:.|......::.:.....:|.....:.|           |:.|
Worm  7014 DIQKQ---------LQIAKATSVREDELVGLDCKNSYFALLACVFL-----------GLPY---- 7054

  Fly   125 KHLTVAPLYFT-------FLGSILVFK-EDCRLYRVKLKSADETVQSKKPLPANMCYTISTTGTT 181
                 ||:..|       |:.|.:.|. |:|....:||::.:...|      ....|:|.|:|:|
Worm  7055 -----APIDPTWPEPRQLFVKSKVSFTLENCFSCNLKLRNFNSRTQ------FGSIYSIFTSGST 7108

  Fly   182 GKPKLIHVPYECIAPNIVGLSQ----KLNVSMADIIYLGTPITFDPFVVEFFLALQNGATLLTSR 242
            |.||.:.:..:.::..:...|:    :.|:.:.|.:    ...||..|.....::.||..|::|.
Worm  7109 GVPKGVLMAEQSVSSFMTSASKQCMFRSNIRVLDSV----KQVFDVSVSNIIGSVLNGGVLISSE 7169

  Fly   243 HS--MRDSPSKVLSALFPDNLATPGITVLQMTPSLFRQFGASSIKDRVLSGSSSLRVLLLGGEPF 305
            ||  :.|...|...|..|              .::|..|     .|:.:|...|:..|.:|||..
Worm  7170 HSTTITDQLQKCQYAFLP--------------AAVFNGF-----TDKTMSRLESIETLTIGGETV 7215

  Fly   306 PSNVELVTWMHPSVLMQKHICNIYGITEISCWSLLH--IVQSLQSPVPLGTPIEEDTVLRIESED 368
             |:|.:.|.|  ....:.....|||.||...|||.:  .|.:|.....||           :|..
Worm  7216 -SDVVIETAM--KKFPRLRTIQIYGPTETCIWSLTNKCKVSTLNIGSALG-----------DSLS 7266

  Fly   369 NET------SQQGELFLGSVK-RRCYIPEVDDQANASQDDSGICFRATGDLVTRQQDGTLFYSER 426
            |||      |.:|.:.:..:. .|.||.........|.      ..:|||:|..:.: :|.|..|
Worm  7267 NETCTICNNSVRGNVQVKGISLARGYITSAPHGTPFSD------IYSTGDIVDSKLN-SLQYIGR 7324

  Fly   427 SNDVVKRAGNRISLGLITRKIQKCLP--------SSELTTCLWLEDLQKLI--CCIRTLESKTRV 481
            .:..||..|.||::..|.:::..||.        |:::.....::...||:  ..::||:::|::
Worm  7325 MDSQVKCKGVRINISEIEKELILCLGLLQIVVLYSNQMLIAFIVDQKSKLLHDSLVKTLKNRTQI 7389

  Fly   482 QQRVQTFDILSKVSIAEQPDRFVYLQHFPCNVHGKLDKQQLLKMCIPLAQPAQQILKSYLHDRL- 545
                              ||.||.:...|.|..||:||..||       |..:.|.|||..:.:
Worm  7390 ------------------PDYFVQINKMPLNSSGKVDKSLLL-------QAFENIRKSYKREIVV 7429

  Fly   546 --ECVEEPDDSASKKQRLDDAAPCGYDLSFRQAGGTSFHAITICREIGLQMCIDDEQRHLFEMLL 608
              ..:||...:...|....:.||..   .|...||.|.:||.|...:..::.|        |:..
Worm  7430 MKNSLEEKVINVFSKILGRNVAPTD---KFESIGGNSLNAIQIAHRLAEELKI--------EIKA 7483

  Fly   609 DENIPLRTVLRFLDTAKLVANNIKRKNVETAVVVSACQSGLIIKRIEQPVLKLQIY 664
            .|.:...::..|.:|.|   |::::...:...|::        |..|.|..|..||
Worm  7484 HEILQSNSLKTFCNTLK---NSVQKPISKVPNVIT--------KLREVPNSKFNIY 7528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aasdh	NP_609230.2	AA-adenyl-dom	46..443	CDD:273779	94/419 (22%)
		AFD_class_I	<168..522	CDD:302604	90/378 (24%)
		PQQ_DH_like	<728..1012	CDD:299747
		PQQ_2	732..978	CDD:290097
pks-1	NP_508923.2	PKS	13..394	CDD:238429
		PKS_KS	57..395	CDD:214836
		KAsynt_C_assoc	<376..>433	CDD:292814
		PP-binding	736..799	CDD:278949
		PKS_KS	830..1197	CDD:214836
		PKS	830..1197	CDD:238429
		hot_dog	1544..1759	CDD:294345
		PKS_PP	<1806..1857	CDD:214834
		PKS	1889..2282	CDD:238429
		PKS_KS	1891..2282	CDD:214836
		PKS_PP	2790..2867	CDD:214834
		PKS_PP	2943..3024	CDD:214834
		PKS_KR	3203..3377	CDD:214833
		PP-binding	3485..3549	CDD:278949
		PksD	<3609..3984	CDD:225858
		PKS_AT	3649..3927	CDD:214838
		hot_dog	3994..4216	CDD:294345
		PKS	4290..4628	CDD:238429
		PRK14691	4335..4629	CDD:173154
		NADB_Rossmann	<4991..5131	CDD:304358
		PP-binding	5168..5230	CDD:278949
		PKS	5258..5645	CDD:238429
		PKS_KS	5260..5646	CDD:214836
		KAsynt_C_assoc	<5628..>5693	CDD:292814
		Acyl_transf_1	5761..6023	CDD:298668
		NADB_Rossmann	<6237..6393	CDD:304358
		PP-binding	6476..6539	CDD:278949
		Condensation	6558..6831	CDD:305010
		AFD_class_I	6990..7412	CDD:302604	114/518 (22%)
		AA-adenyl-dom	7000..7356	CDD:273779	97/434 (22%)
		PP-binding	7436..7499	CDD:278949	15/73 (21%)
		Abhydrolase	7527..>7622	CDD:304388	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1020
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810