Protein Alignment Aasdh and AASDH

DIOPT Version :9

• Sequence 1: NP_609230.2
• Gene: Aasdh / 34175
• FlyBaseID: FBgn0027780
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_001310819.1
• Gene: AASDH / 132949
• HGNCID: 23993
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 1194
• Identity: 310/1194 - (25%)
• Similarity: 488/1194 - (40%)
• Gaps: 320/1194 - (26%)

  Fly    43 TIVSYADAADEIQVLMNFL---------RKNGVPDEAGIALRVTEHTPASSLMILAILNNKCHFF 98
            |..:..:||.|   |.|||         |:.|:..:.||.|      |:   .||.||.....:.
Human    34 TYKTVVNAASE---LSNFLLLHCDFQGIREIGLYCQPGIDL------PS---WILGILQVPAAYV 86

  Fly    99 PTDKMMLSQDLYSQMST-----AGVDYLVANK---------HLTVAPLYFTFLGSILVFKEDCRL 149
            |     :..|....:||     ..:.|::..|         |.|:.. |.||    .|...|..|
Human    87 P-----IEPDSPPSLSTHFMKKCNLKYILVEKKQINKFKSFHETLLN-YDTF----TVEHNDLVL 141

  Fly   150 YRV---------------------KLKS-ADETVQSKKP-------LPANMCYTISTTGTTGKPK 185
            :|:                     |:|| :.|.|..:|.       |...:.|.:.|:||||.||
Human   142 FRLHWKNTEVNLMLNDGKEKYEKEKIKSISSEHVNEEKAEEHMDLRLKHCLAYVLHTSGTTGIPK 206

  Fly   186 LIHVPYECIAPNIVGLSQKLNVSMADIIYLGTPITFDPFVVEFFLALQNGATLLTSRHSMRDSPS 250
            ::.||::||.|||.......:::..|:::|.:|:||||.|||.||||.:||:||....|::..||
Human   207 IVRVPHKCIVPNIQHFRVLFDITQEDVLFLASPLTFDPSVVEIFLALSSGASLLIVPTSVKLLPS 271

  Fly   251 KVLSALFPDNLATPGITVLQMTPSLFRQFGASSIKDRVLSGSSSLRVLLLGGEPFPSNVELVTWM 315
            |:.|.||..:    .:||||.||:|.|:||:..||..|||.::|||||.||||.|||...|.:|.
Human   272 KLASVLFSHH----RVTVLQATPTLLRRFGSQLIKSTVLSATTSLRVLALGGEAFPSLTVLRSWR 332

  Fly   316 HPSVLMQKHICNIYGITEISCWSLLHIV--QSLQS------PVPLGTPIEEDTVLRIESEDNETS 372
            ......|  |.|:|||||:|.|:.::.:  ::|.|      ||.||.|: ..||:.:...:..|.
Human   333 GEGNKTQ--IFNVYGITEVSSWATIYRIPEKTLNSTLKCELPVQLGFPL-LGTVVEVRDTNGFTI 394

  Fly   373 QQ--GELFLGSVKRRCYIPEVDDQANASQDDSGICFRATGDLVTRQQDGTLFYSERSNDVVKRAG 435
            |:  |::|||...|.|::   ||:......    ..|||||.|| .:||.:|:..|.:..:||.|
Human   395 QEGSGQVFLGGRNRVCFL---DDEVTVPLG----TMRATGDFVT-VKDGEIFFLGRKDSQIKRHG 451

  Fly   436 NRISLGLITRKIQKCLPSSELTTCLWLEDLQKLICCIRTLESKTRVQQRVQTFDILSKVSIAEQ- 499
            .|:::.|:.:.               .|:||::..|..|..:    |:::..|.:....|:.|.
Human   452 KRLNIELVQQV---------------AEELQQVESCAVTWYN----QEKLILFMVSKDASVKEYI 497

  Fly   500 -------------PDRFVYLQHFPCNVHGKLDKQQLLKMCI---------------PLAQPAQQI 536
                         ||..|.:...|...|||:|..:|.|:.:               .|.:..|.:
Human   498 FKELQKYLPSHAVPDELVLIDSLPFTSHGKIDVSELNKIYLNYINLKSENKLSGKEDLWEKLQYL 562

  Fly   537 LKSYLHDRLECVEEPDDSASKKQRLDDAAPCGYDLSFRQAGGTSFHAITICREIG---------- 591
            .||.|:...:.:..||:|.                 |..:||.|..:|.:..||.
Human   563 WKSTLNLPEDLLRVPDESL-----------------FLNSGGDSLKSIRLLSEIEKLVGTSVPGL 610

  Fly   592 ----LQMCIDDEQRHLFEMLL-DENIPLR------TVLRFLDTAKLVANNIKRKNVET------- 638
                |...|.:...|:.:.:: ||::..|      ..|..::..:....::.:|.:.|
Human   611 LEIILSSSILEIYNHILQTVVPDEDVTFRKSCATKRKLSDINQEEASGTSLHQKAIMTFTCHNEI 675

  Fly   639 -AVVV-----------------------SACQSGLI-------IKRIEQPVL------------- 659
             |.||                       |||.|..:       :|.:..|||
Human   676 NAFVVLSRGSQILSLNSTRFLTKLGHCSSACPSDSVSQTNIQNLKGLNSPVLIGKSKDPSCVAKV 740

  Fly   660 -------------KLQIYWKVNFEKCIDS------PVTEYEGRFICVGAHSKILRTLNPQTGSEY 705
                         :|.:.|:.:..||:|:      |..:.....:.:|:||..::.::..:|...
Human   741 SEEGKPAIGTQKMELHVRWRSDTGKCVDASPLVVIPTFDKSSTTVYIGSHSHRMKAVDFYSGKVK 805

  Fly   706 SVVKLPERIECK---------VTFLTEQLAMV-------------------------------GC 730
            ....|.:|||..         :...||.|.:|                               ||
Human   806 WEQILGDRIESSACVSKCGNFIVVETELLRVVQAGLKLPGSSDLPTSASQSAEITGVSHHVWPGC 870

  Fly   731 YDGCLYGFNPQTGNIVFRVGIGGLIKSQPMLTADGRRIIVCSYADDYNVYCLSAERQEVLWCLRI 795
            |:|.:|.....:|...:.......:||...:......|.:.|:  |.:.|.|...|::.:|..:.
Human   871 YNGLVYVLKSNSGEKYWMFTTEDAVKSSATMDPTTGLIYIGSH--DQHAYALDIYRKKCVWKSKC 933

  Fly   796 GEKPIFASPLELPREQSLIVCTLDGSYSRVAITDGSVEWTQKFREPVFSTPVLLESVSNIFLSAE 860
            | ..:|:||........|...||.|....|....|:|.|.....:|:||:|   :..|.......
Human   934 G-GTVFSSPCLNLIPHHLYFATLGGLLLAVNPATGNVIWKHSCGKPLFSSP---QCCSQYICIGC 994

  Fly   861 VAGRVHACHVGNGKILATFSTEGNIFSSLVVKTPPTFMGHSFAIFGCIDQHLYCLRCKTGPGGKS 925
            |.|.: .|....|:.:..|||.|.||||     |.|........||..|..:||...|.
Human   995 VDGNL-LCFTHFGEQVWQFSTSGPIFSS-----PCTSPSEQKIFFGSHDCFIYCCNMKG------ 1047

  Fly   926 VELELHWKVDVGAPIYATPTLLTVQ--PNGLLVWCAATDGRVMLINFRNGEIQWSDKLPGQVFSS 988
               .|.||.:..:.:||||......  .|.:|:..|:|||:|.::..::|::|...:|||:||||
Human  1048 ---HLQWKFETTSRVYATPFAFHNYNGSNEMLLAAASTDGKVWILESQSGQLQSVYELPGEVFSS 1109

  Fly   989 ACFIEDLRRVFVGCRDNFLYCLGI 1012
            ...:|.:  :.:|||||::|||.:
Human  1110 PVVLESM--LIIGCRDNYVYCLDL 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aasdh	NP_609230.2	AA-adenyl-dom	46..443	CDD:273779	152/458 (33%)
		AFD_class_I	<168..522	CDD:302604	131/377 (35%)
		PQQ_DH_like	<728..1012	CDD:299747	85/316 (27%)
		PQQ_2	732..978	CDD:290097	65/247 (26%)
AASDH	NP_001310819.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159679
Domainoid	1	1.000	179	1.000	Domainoid score	I3555
eggNOG	1	0.900	-	-		E1_COG1020
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71711
Inparanoid	1	1.050	214	1.000	Inparanoid score	I3633
Isobase	1	0.950	-	0	Normalized mean entropy	S6452
OMA	1	1.010	-	-		QHG60259
OrthoDB	1	1.010	-	-		D424682at33208
OrthoFinder	1	1.000	-	-		FOG0002418
OrthoInspector	1	1.000	-	-		oto89424
orthoMCL	1	0.900	-	-		OOG6_100454
Panther	1	1.100	-	-	LDO	PTHR44394
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5888
SonicParanoid	1	1.000	-	-		X5394
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750