DRSC/TRiP Functional Genomics Resources

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Protein Alignment D12 and YEATS2

DIOPT Version :9

Sequence 1:NP_609228.2 Gene:D12 / 34172 FlyBaseID:FBgn0027490 Length:969 Species:Drosophila melanogaster
Sequence 2:NP_001338299.1 Gene:YEATS2 / 55689 HGNCID:25489 Length:1423 Species:Homo sapiens


Alignment Length:1522 Identity:279/1522 - (18%)
Similarity:469/1522 - (30%) Gaps:693/1522 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 DPDYQQTEVSSQDEEETCAEAESPGQR-KWTKTEQSDGMLPLSDKFQRIRELLRLEFQREISQKV 82
            ||||:...|:            .|.:| |..:....|..:      |:|..:::.:|..|:..|.
Human    12 DPDYEDVSVA------------LPNKRHKAIENSARDAAV------QKIETIIKEQFALEMKNKE 58

  Fly    83 EQLAEIDRRLLQGRQLLDRLRYQVVSEYYRKQQVPLTGADIAKVRGDSLFGDDIAAPQLPLHPAI 147
            .::..||:||::.|:::|:||..:|:.||       ..|.:.||...|...|.:...    ||||
Human    59 HEIEVIDQRLIEARRMMDKLRACIVANYY-------ASAGLLKVSEGSKTCDTMVFN----HPAI 112

  Fly   148 KKIVGKRPVVIQNHLPERTAATLAKETIRLRNPAHRRAERRRQQKIKEQGIVTDHS-----KDKK 207
            ||.:         ..|.|::           :||::|||...... .|...::.|:     ||..
Human   113 KKFL---------ESPSRSS-----------SPANQRAETPSANH-SESDSLSQHNDFLSDKDNN 156

  Fly   208 DQPEQEPPISVKLEDEQPC------TSR-----QAHERQVEL--NASRLNNKNKFNFVVGNTSKY 259
            ...:.|..:|..:| ::|.      |||     :..:|..:|  ..|||..|.  ..||||.|||
Human   157 SNMDIEERLSNNME-QRPSRNTGRDTSRITGSHKTEQRNADLTDETSRLFVKK--TIVVGNVSKY 218

  Fly   260 IGEDSRENGTGGNALTYKWLVYVQGKDLPEPLEKYIKKVRFHLHPSYRPNDIVDVHRSPFQLNRH 324
            |..|.||.   .:..|:||:|||:|......:..::|||.|.|||||:|||:|:|...||.|.|.
Human   219 IPPDKREE---NDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRR 280

  Fly   325 GWGEFPMRIQLFFQEHLQQKPVQLMHTVVLDKTMCGLHTMGAETTVEIWLR-------------- 375
            ||||||:|:|:.|::. |.|.:.::|.:.||:|..||.|:||||.|::.|.              
Human   281 GWGEFPVRVQVHFKDS-QNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDCIYPQSS 344

  Fly   376 ------------------AKQAITKQKSGKPHPPHEQETA-VPA--------PPLAAPNVLE--P 411
                              .|.:...::|.:|.|....|.| .||        |..|.|:.||  |
Human   345 ESDISDAPPSLPLTIPAPVKASSPIKQSHEPVPDTSVEKAGFPASTEAERHTPFYALPSSLERTP 409

  Fly   412 SVF--------------AF--------------------PGESCKPRTIS--------------- 427
            :..              ||                    ||:|.:|.|:|               
Human   410 TKMTTSQKVTFCSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITMSCKIVSGSPISTPSPS 474

  Fly   428 --------------------------ITQNKE--------------------------------- 433
                                      :..:|:                                 
Human   475 PLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPGQVIGATTPSTGSPTNKISTASQVSQGTGSPV 539

  Fly   434 -------------ELDDNLFAGI---------NKIE-----------LSDDIEKIEP-------- 457
                         :.:|:|||.:         .|::           .:..|.|.||        
Human   540 PKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAFTKVIIKQEPGEAPHVPA 604

  Fly   458 TVLVSE-PL----------KLNYSPRKQPPTP---------------------SSPPRTQLR--- 487
            |...|: ||          .:..||:||..||                     |:.|.|..:   
Human   605 TGAASQSPLPQYVTVKGGHMIAVSPQKQVITPGEGIAQSAKVQPSKVVGVPVGSALPSTVKQAVA 669

  Fly   488 ------------------------------------------------LNAAQVTASKP------ 498
                                                            |..|||||:.|      
Human   670 ISGGQILVAKASSSVSKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKAQVTAAGPQKSGSQ 734

  Fly   499 -----------------------SVVYLPVNGRSPRQES----LPE------------------- 517
                                   :.:||..|.::|..:.    :|:                   
Human   735 GSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAAS 799

  Fly   518 ---------------------------------------------RQRQEFSP--VKHYPPA--- 532
                                                         .|...::.  :|..|..   
Human   800 GGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQSTAGPGGISQHLTYTSYILKQTPQGTFL 864

  Fly   533 ----SPQRAWKE----------------SSSDRPPIKPVPNGHHQGKKNVVFQRA---GKLYIID 574
                |||.:.|:                |:..:..:|.:     .|:|..:|.:|   |:..::.
Human   865 VGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVI-----SGQKTTLFTQAAHGGQASLMK 924

  Fly   575 PLQRKLKQAAKQQSLLKPQLSLLK-----------------------------PPS--------E 602
            .....||.......|.||..::|:                             |.|        :
Human   925 ISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTK 989

  Fly   603 TRWHMLQCMQHD-------------------------HGYANMSGEME----------------- 625
            |......|:...                         .|.|.:||.::                 
Human   990 TSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISGKATVSGLLKIHSSQSSPQQAVLTIPS 1054

  Fly   626 ------------------------------EKPMLLP-----PIVDTT-------IQSRPR---- 644
                                          :.|.:||     |:|.::       :::.|.    
Human  1055 QLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILPVAAPTPVVPSSAPAAVAKVKTEPETPGP 1119

  Fly   645 ------------------------RLEHIFRSAQFRNMRSAVEFLLSRLPLASIDQQKEYPFTCI 685
                                    :::|:      ..::..:..::.::||.:...:....|:..
Human  1120 SCLSQEGQTAVKTEESSELGNYVIKIDHL------ETIQQLLTAVVKKIPLITAKSEDASCFSAK 1178

  Fly   686 TLEEFHNHTALKQRCFEYLRARMLRRCLMQ-------HHELHKLDISGKEHYWSLREIVAFARVH 743
            ::|:::.....|:|..|:.||..:|:.|.:       .|.|..|         ..:.|..:.|.|
Human  1179 SVEQYYGWNIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPL---------KTKHIAHWCRCH 1234

  Fly   744 GYTPALKDVLPVVHEKRKQKLSDEEQLARRVQAQLKGEPQPQLSAYSSLSSGNRLEAWITKQSDR 808
            ||||      |.....|....|.|:     |..|:..||:    ..||.||.:.|   ..|..|.
Human  1235 GYTP------PDPESLRNDGDSIED-----VLTQIDSEPE----CPSSFSSADNL---CRKLEDL 1281

  Fly   809 LLGHDQQMRDKEFIDVLGVDKPHPL---ASRLTNSADVSFQMVNHRQLLYLPPPKHLDSTLQLVQ 870
            .....::..::|.:|:|.:.:|..:   ..:.....:|.|         ||||    ....:.:.
Human  1282 QQFQKREPENEEEVDILSLSEPVKINIKKEQEEKQEEVKF---------YLPP----TPGSEFIG 1333

  Fly   871 EMCKDINITLEPEESPPGVSQPLALSMLGQVLRTFIEKLVRRSLAAKLQQETLEQLPPAAANAPL 935
            ::.:.|.|||:|......|...:...|:.:.....:..::|::||...|..:..::|..      
Human  1334 DVTQKIGITLQPVALHRNVYASVVEDMILKATEQLVNDILRQALAVGYQTASHNRIPKE------ 1392

  Fly   936 CLQPQDIGRVISLCSELDFLGNSHLGV 962
             :...:|.:.|.....||||.|.|:|:
Human  1393 -ITVSNIHQAICNIPFLDFLTNKHMGI 1418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
D12NP_609228.2 YEATS 275..357 CDD:281374 39/81 (48%)
YEATS2NP_001338299.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..198 19/93 (20%)
YEATS 231..310 CDD:308783 37/79 (47%)
Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL 259..261 1/1 (100%)
Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL 282..284 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 466..487 0/20 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..541 0/26 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 795..843 0/47 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149189
Domainoid 1 1.000 94 1.000 Domainoid score I7517
eggNOG 1 0.900 - - E1_COG5033
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 219 1.000 Inparanoid score I3584
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1482359at2759
OrthoFinder 1 1.000 - - FOG0009207
OrthoInspector 1 1.000 - - oto91640
orthoMCL 1 0.900 - - OOG6_106758
Panther 1 1.100 - - LDO PTHR23195
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R8511
SonicParanoid 1 1.000 - - X6947
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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