Protein Alignment D12 and Yeats2

DIOPT Version :10

• Sequence 1: NP_609228.2
• Gene: D12 / 34172
• FlyBaseID: FBgn0027490
• Length: 969
• Species: Drosophila melanogaster
• Sequence 2: NP_001102527.1
• Gene: Yeats2 / 498112
• RGDID: 1566176
• Length: 1405
• Species: Rattus norvegicus
• Alignment Length: 1510
• Identity: 271/1510 - (17%)
• Similarity: 435/1510 - (28%)
• Gaps: 689/1510 - (45%)

  Fly    19 DPDYQQTEVSSQDEEETCAEAESPGQRKWTKTEQSDGMLPLSDKFQRIRELLRLEFQREISQKVE 83
            ||||:...|:...:.....|:.:           .|..:      |:|..:::.:|..|:..|..
  Rat    12 DPDYEDVSVALPSKRHKAIESSA-----------RDAAV------QKIETIIKEQFALEMKNKEH 59

  Fly    84 QLAEIDRRLLQGRQLLDRLRYQVVSEYYRKQQVPLTGADIAKV-RGDSLFGDDIAAPQLPLHPAI 147
            ::..||:||::.|:::|:||..:|:.||       ..|.:.|| .|...|.     |....||||
  Rat    60 EIDVIDQRLIEARRMMDKLRACIVANYY-------ASAGLLKVSEGLKTFD-----PMAFNHPAI 112

  Fly   148 KKIVGKRPVVIQNHLPERTAATLAKETIRLRNPAHRRAERRRQQKIKEQGIVTDHSKDKKDQPEQ 212
            ||.:         ..|.|::           :|.::|:|...... .|...::.|:....|:...
  Rat   113 KKFL---------ESPSRSS-----------SPTNQRSETPSANH-SESDSLSQHNDFLSDKDNN 156

  Fly   213 EPPISVKLEDEQPCTSRQAHERQVELNASRLNNKN-------------------KFNFVVGNTSK 258
            .   :|.:|:.......|...|....:.|.::..:                   |...||||.||
  Rat   157 S---NVDVEERLSSIGEQRLSRNTGRDTSSISGSHKRELRSADLAGDETSRLFVKKTIVVGNVSK 218

  Fly   259 YIGEDSRENGTGGNALTYKWLVYVQGKDLPEPLEKYIKKVRFHLHPSYRPNDIVDVHRSPFQLNR 323
            ||..|.||.   .:..|:||:|||:|......:..::|||.|.|||||:|||:|:|...||.|.|
  Rat   219 YIPPDKREE---NDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTR 280

  Fly   324 HGWGEFPMRIQLFFQEHLQQKPVQLMHTVVLDKTMCGLHTMGAETTVEIWLRA---------KQA 379
            .||||||:|:|:.|::. |.|.:.::|.:.||:|..||.|:||||.|::.|..         .|:
  Rat   281 RGWGEFPVRVQVHFKDS-QNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDYVYPQS 344

  Fly   380 ITKQKSGKPHPPHEQETAVPAPPLAAP--NVLEPSVFAFPGESCKPRTISITQNKEELDDNLFAG 442
            .....|..|.|    ...:|||..|:|  ...||:..|..||.....|      :.|....|::
  Rat   345 SESDISDAPPP----SLTIPAPVKASPVARSPEPASAAPVGEGFPDST------EAERHSTLYS- 398

  Fly   443 INKIELSDDIEKIEPTVLVSEPLKLNYS-----------------PRKQPPTPSSP--------- 481
                 |...:|:....|..::  |:.:|                 |:.|.|.|.||
  Rat   399 -----LPSSLERTPTKVTAAQ--KVTFSSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITM 456

  Fly   482 ------------------PRT------QLRLNAAQVTASKPSVVY-------------------- 502
                              |||      .|:..:|....|.|..:.
  Rat   457 SCKIVSGSPISTPSPSPLPRTPTSTPVHLKQGSASAGISNPHAIVDKPGQATGASAPSAGSPTSK 521

  Fly   503 LPVNGR------SP--------------RQE--------------SLPERQ-------------- 519
            |||..:      ||              :||              |.|:.|
  Rat   522 LPVASQASQGTGSPVPKIHGSSFLTSTVKQEDSLFASMPPLCPIGSHPKVQSPKAVTGGLGAFTK 586

  Fly   520 ---RQE--------------------FSPVK--HYPPASPQR---AWKESSSDRPPIKP-----V 551
               :||                    :..||  |....|||:   :..|..:..|.|.|     |
  Rat   587 VIIKQEPGETPHVSTTGAANQSAFPQYVTVKGGHMIAVSPQKQVLSAGEGITQSPKIPPSKVVGV 651

  Fly   552 PNG----------------------------HHQGKKNVVFQRA--------------------- 567
            |.|                            ...|.|.||.|..
  Rat   652 PVGSALPSTVKQAVAISSGQILVAKASSSITKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLT 716

  Fly   568 -----------------------------------------------------GKLYIID----- 574
                                                                 |||.:|.
  Rat   717 KTQVTAAGPPKTGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAIL 781

  Fly   575 ----------------------------------------------------------------- 574
                                                                             
  Rat   782 RATNNANLQSGSAAAGGSGGSCGAGGGGGGGGGAGGAPSTSGPGGGPQHLTYTSYILKQTPQGTF 846

  Fly   575 -------------------------------PLQRKLK-----------QAAK--QQSLLK---- 591
                                           |.|:.||           |||.  |.||||
  Rat   847 LVGQPSPQTPGKQLTTASVVQGTLGVSTSSAPGQQTLKVISGQKTTLFTQAATAGQASLLKLPDN 911

  Fly   592 --------PQL---------------------------------------------SLLKPPSE- 602
                    |||                                             |::|.|.:
  Rat   912 TLKSVPAAPQLAKPGTTMLRVAGGVITAAPSPAVAFSANGAVHQAEGSAPVSSSVGSIIKTPGQP 976

  Fly   603 --------------------TRWHMLQCMQHDHGYANMSGEME---------------------- 625
                                |...::.......|.|.:||.::
  Rat   977 QVCVSQATMATCKATAPAAVTAASLVSAPSSISGKATVSGLLKIHSGQCSPQQAVLTIPSQLKPL 1041

  Fly   626 -------------------------EKPMLLP------------PIVDTTIQSRPRR-------- 645
                                     :.|.:||            |:....:::.|..
  Rat  1042 SINTSGGVQTVLMPVNKVVQSFSTSKLPTVLPISVPNPAAPSPAPVTIAKVKTEPETPGPNCVSQ 1106

  Fly   646 --------------LEHIFRSAQFRNMRSAVEFLLSRLPLASIDQQKEYPFTCITLEEFHNHTAL 696
                          ..::.:......::..:..::.::||.:........|:..:||:::.....
  Rat  1107 ETQIAVKTEESSELSNYVIQVDHLETIQQLLTAVVKKIPLITAKGNDTSCFSAKSLEQYYGWNIG 1171

  Fly   697 KQRCFEYLRARMLRRCLMQ----HHELHKLDISGKEHYWSLREIVAFARVHGYTPALKDVLPVVH 757
            |:|..|:.||..:|:.|.:    :...|.|.....:|      |..:.|.|||||
  Rat  1172 KRRAAEWQRAMTVRKVLQEILERNPRFHHLTALKTKH------IAHWCRCHGYTP---------- 1220

  Fly   758 EKRKQKLSDEEQLARR------VQAQLKGEPQPQLSAYSSLSSGNRLEAWITKQSDRLLGHDQQM 816
                   .|.|.|...      |..|:..||:    ..||.|:.:.|   ..|..|......::.
  Rat  1221 -------PDPESLRHNGDSIEDVLTQIDSEPE----CLSSFSTADDL---CRKLEDLQQFQKREP 1271

  Fly   817 RDKEFIDVLGVDKPHPLASRLTNSADVSFQMVNHRQLLYLPPPKHLDSTLQLVQEMCKDINITLE 881
            .::|.:|:|.:.:|      |..:.....:........||||.....    .|.::.:.|.|||:
  Rat  1272 ENEEEVDILSLSEP------LKTNIKKEQEEKQEEMRFYLPPTPGSG----FVGDITQKIGITLQ 1326

  Fly   882 PEESPPGVSQPLALSMLGQVLRTFIEKLVRRSLAAKLQQETLEQLPPAAANAPLCLQPQDIGRVI 946
            |......:...:...|:.:.....:..::|::||...|..:..::|..       :...:|.:.|
  Rat  1327 PVALHRNMYASVVEDMILKATEQLVSDILRQALAVGYQTASPNRIPKE-------ITVSNIHQAI 1384

  Fly   947 SLCSELDFLGNSHLG 961
            .....||||.|.|:|
  Rat  1385 CNIPFLDFLTNKHMG 1399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D12	NP_609228.2	YEATS_YEATS2_like	249..375	CDD:341126	59/125 (47%)
Yeats2	NP_001102527.1	YEATS_YEATS2_like	209..332	CDD:341126	60/126 (48%)
		PHA03247	<342..653	CDD:223021	58/328 (18%)