Protein Alignment D12 and MLLT3

DIOPT Version :10

• Sequence 1: NP_609228.2
• Gene: D12 / 34172
• FlyBaseID: FBgn0027490
• Length: 969
• Species: Drosophila melanogaster
• Sequence 2: NP_004520.2
• Gene: MLLT3 / 4300
• HGNCID: 7136
• Length: 568
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 122/690 - (17%)
• Similarity: 228/690 - (33%)
• Gaps: 230/690 - (33%)

  Fly   275 TYKWLVYVQGKDLPE--PLEKYIKKVRFHLHPSY-RPNDIVDVHRSPFQLNRHGWGEFPMRIQLF 336
            |:.|:|:|:|   ||  .::.:::||.||||.|: ||..:  ....|:::...|:..|.:.|:::
Human    29 THDWMVFVRG---PEHSNIQHFVEKVVFHLHESFPRPKRV--CKDPPYKVEESGYAGFILPIEVY 88

  Fly   337 FQEHLQQKPVQLMHTVVLDKTMCGLHTMGAETTVEIWLRAKQAITKQKSGKPHPP--HEQETAVP 399
            |:...:.:.|:..:.:.       ||..|                       |||  |.:
Human    89 FKNKEEPRKVRFDYDLF-------LHLEG-----------------------HPPVNHLR----- 118

  Fly   400 APPLAAPNVLEPSVFAFPGESCKPRTISITQNKEELDDNLFAGINKIELSDDIEKIEPTVLVSEP 464
                     .|...|..|.|..:.:.:.             ||      .|....|..:...|..
Human   119 ---------CEKLTFNNPTEDFRRKLLK-------------AG------GDPNRSIHTSSSSSSS 155

  Fly   465 LKLNYSPRKQPPTPSSPPRTQLRLNAAQVTASKPSVVYLPVNGRSPRQESLPERQRQEFSPVKHY 529
            ...:.|......:.||...:....:::..::|..|..:...:......:..|.:..:|.......
Human   156 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKE 220

  Fly   530 PPASPQRAWKESSSDRPPIKPVPNGHHQGKKNVVFQRAGKLYIIDPLQRKLKQAAKQQSLLKPQL 594
            |.....::.||||......||:.      ::.:|.:.|.|    :|     |..:|:.   ||..
Human   221 PSRDHNKSSKESSKKPKENKPLK------EEKIVPKMAFK----EP-----KPMSKEP---KPDS 267

  Fly   595 SLLKPPSETRWHMLQCMQHDHGYANMSGEMEEKPMLLPPIVDTTIQSRPRRLEHIFRSAQFRNMR 659
            :||                    ...||:.::.|...|||.|:...|..:| :.....|.|::..
Human   268 NLL--------------------TITSGQDKKAPSKRPPISDSEELSAKKR-KKSSSEALFKSFS 311

  Fly   660 SAVEFLLSRLPLASIDQQKEYPFTCITLEEFHNHTALKQRCFEYLRARMLRRCLMQHHELHKLDI 724
            ||...:|:    .|.|:::                 :|.:               .|.::.|:.|
Human   312 SAPPLILT----CSADKKQ-----------------IKDK---------------SHVKMGKVKI 340

  Fly   725 SGKEHYWSLREIVAFARVHGYTPALKDVLPVVHEKRKQKL-----------SD-EEQLARRVQAQ 777
            ..:                            ..||:|..|           || ||.::.:..::
Human   341 ESE----------------------------TSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSE 377

  Fly   778 LKGEPQPQLSAYSSLSSGNRLEAWITKQ-------------------SDRLLGHDQQMRDKEFID 823
               :|.|..|:.||.||....:   |:|                   ||.:..:|.....:..::
Human   378 ---QPSPASSSSSSSSSFTPSQ---TRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVN 436

  Fly   824 VLGVDKPHPLASRLTNSADVSFQMVNHRQLLYLPPPKHLDSTLQLVQEMCKDINITLEPEESPPG 888
            ..|........|..::|...|.....|.:    |||..|.:....:.|:           :||..
Human   437 RGGSRSRRVSLSDGSDSESSSASSPLHHE----PPPPLLKTNNNQILEV-----------KSPIK 486

  Fly   889 VSQPLALSMLGQVLRTFIEKLV--RRSLAAKLQQETLEQL 926
            .|:.......|:..:.::::||  .|.|....::..|:|:
Human   487 QSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQI 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D12	NP_609228.2	YEATS_YEATS2_like	249..375	CDD:341126	25/102 (25%)
MLLT3	NP_004520.2	YEATS_AF-9_like	9..137	CDD:341125	33/156 (21%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	78..80		0/1 (0%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	106..108		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..475		78/455 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	295..300		1/5 (20%)
		AHD	503..563	CDD:436050	6/24 (25%)