Protein Alignment D12 and MLLT1

DIOPT Version :10

• Sequence 1: NP_609228.2
• Gene: D12 / 34172
• FlyBaseID: FBgn0027490
• Length: 969
• Species: Drosophila melanogaster
• Sequence 2: XP_011526323.1
• Gene: MLLT1 / 4298
• HGNCID: 7134
• Length: 600
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 137/691 - (19%)
• Similarity: 217/691 - (31%)
• Gaps: 240/691 - (34%)

  Fly   275 TYKWLVYVQGKDLPE--PLEKYIKKVRFHLHPSY-RPNDIVDVHRSPFQLNRHGWGEFPMRIQLF 336
            |:.|:|:|:|   ||  .::.:::||.|.||.|: :|..:  ....|:::...|:..|.|.|::.
Human    70 THDWMVFVRG---PEQCDIQHFVEKVVFWLHDSFPKPRRV--CKEPPYKVEESGYAGFIMPIEVH 129

  Fly   337 FQEHLQQKPVQLMHTVVL--------DKTMCGLHTMGAETTVEIW--LRAKQAITKQKS----GK 387
            |:...:.:.|...:.:.|        :...|...|....||...:  |||...:...:.    .:
Human   130 FKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSR 194

  Fly   388 PHPPHEQETAVPAPPLAAPNVLEPSVFAFPGESCKPRTISITQNKEELDDNLFAGINKIELSDDI 452
            |.|.:..   :|..||:|        |:.| :..||...|...|||
Human   195 PSPDYPM---LPTIPLSA--------FSDP-KKTKPSHGSKDANKE------------------- 228

  Fly   453 EKIEPTVLVSEPLKLNYSPRKQPPTPSSPPRTQLRLNAAQVTASKPSVVYLPVNGRSPRQESLP- 516
                 :...|:|.|:....|::|...|....:...|...|..:||.:...|. .||.|::|..|
Human   229 -----SSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLG-EGRLPKEEKAPP 287

  Fly   517 -------------ERQRQEFSPV--KHYPPASPQRAWKESSSDRPPI--KPVPNGHHQGKKNVVF 564
                         |.:.:..||.  ...||..|.||    ||.||..  .|.|:...|.|.:...
Human   288 PKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRA----SSKRPATADSPKPSAKKQKKSSSKG 348

  Fly   565 QRAGKLYIIDPLQRKLKQAAKQQSLLKPQLSLLKPPSETRWHMLQCMQHDHGYANMSGEMEEKPM 629
            .|:.      |.......::...|..||    .|..|.||...::. :.:...|..:.|:||.
Human   349 SRSA------PGTSPRTSSSSSFSDKKP----AKDKSSTRGEKVKA-ESEPREAKKALEVEES-- 400

  Fly   630 LLPPIVDTTIQSRPRRLEHIFR--SAQFRNMRSAVEFLLSRLPLASIDQQKEYPFTCITLEEFHN 692
                      .|..   |..|:  |||.....|:          :|.|...:..|     |...|
Human   401 ----------NSED---EASFKSESAQSSPSNSS----------SSSDSSSDSDF-----EPSQN 437

  Fly   693 HTALKQRCFEYLRARMLRRCLMQHHELHKLDISGKEHYWSLREIVAFARVHGYTPALKDVLPVVH 757
            |:                                   ...||.:|
Human   438 HS-----------------------------------QGPLRSMV-------------------- 447

  Fly   758 EKRKQKLSDEEQLARRVQAQLKGEPQPQLSAYSSLSSGNRLEAWITKQSDRLLGHDQQMRDKEFI 822
            |..:.:.|||:..:...:|..|..|                            |.|.::   .|.
Human   448 EDLQSEESDEDDSSSGEEAAGKTNP----------------------------GRDSRL---SFS 481

  Fly   823 DVLGVDKPHPLASRLTNSADVSFQMVNHRQLLYLPPPKHLDSTLQLVQEMCKDINITLEPEESPP 887
            |           |...||||.|............|||                 |..:....||.
Human   482 D-----------SESDNSADSSLPSREPPPPQKPPPP-----------------NSKVSGRRSPE 518

  Fly   888 GVSQPLALSMLGQVLRTFIEKLV--RRSLAAKLQQETLEQL 926
            ..|:|..:...|...:.:.::||  .|.|.|..::..|:|:
Human   519 SCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQI 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D12	NP_609228.2	YEATS_YEATS2_like	249..375	CDD:341126	26/112 (23%)
MLLT1	XP_011526323.1	YEATS_AF-9_like	50..178	CDD:341125	26/112 (23%)
		AHD	536..596	CDD:436050	7/24 (29%)