Protein Alignment D12 and Yeats2

DIOPT Version :10

• Sequence 1: NP_609228.2
• Gene: D12 / 34172
• FlyBaseID: FBgn0027490
• Length: 969
• Species: Drosophila melanogaster
• Sequence 2: NP_001139402.1
• Gene: Yeats2 / 208146
• MGIID: 2447762
• Length: 1407
• Species: Mus musculus
• Alignment Length: 1499
• Identity: 279/1499 - (18%)
• Similarity: 443/1499 - (29%)
• Gaps: 665/1499 - (44%)

  Fly    19 DPDYQQTEVSSQDEEETCAEAESPGQRKWTKTEQSDGMLPLSDKFQRIRELLRLEFQREISQKVE 83
            ||||:...|:..::.....|:.:           .|..:      |:|..:::.:|..|:..|..
Mouse    12 DPDYEDVSVALPNKRHKAIESSA-----------RDAAV------QKIETIIKEQFALEMKNKEH 59

  Fly    84 QLAEIDRRLLQGRQLLDRLRYQVVSEYYRKQQVPLTGADIAKV-RGDSLFGDDIAAPQLPLHPAI 147
            ::..||:||::.|:::|:||..:|:.||       ..|.:.|| .|...|.     |....||||
Mouse    60 EIDVIDQRLIEARRMMDKLRACIVANYY-------ASAGLLKVSEGLKTFD-----PMAFNHPAI 112

  Fly   148 KKIVGKRPVVIQNHLPERTAATLAKETIRLRNPAHRRAERRRQQKIKEQGIVTDHSKDKKDQPEQ 212
            ||.:         ..|.|::           :|.::|:|...... .|...::.|:....|:...
Mouse   113 KKFL---------ESPSRSS-----------SPTNQRSETPSANH-SESDSLSQHNDFLSDKDNN 156

  Fly   213 EPPISVKLEDEQPCTSRQ---------------AHERQVELNASRLNNKN-----KFNFVVGNTS 257
            .   :|.:|:..|.|..|               :|:|::. ||....::.     |...||||.|
Mouse   157 S---NVDVEERPPSTGEQRPSRKAGRDTSSISGSHKRELR-NADLTGDETSRLFVKKTIVVGNVS 217

  Fly   258 KYIGEDSRENGTGGNALTYKWLVYVQGKDLPEPLEKYIKKVRFHLHPSYRPNDIVDVHRSPFQLN 322
            |||..|.||.   .:..|:||:|||:|......:..::|||.|.|||||:|||:|:|...||.|.
Mouse   218 KYIPPDKREE---NDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLT 279

  Fly   323 RHGWGEFPMRIQLFFQEHLQQKPVQLMHTVVLDKTMCGLHTMGAETTVEIWLRAKQAITKQKSGK 387
            |.||||||:|:|:.|::. |.|.:.::|.:.||:|..||.|:||||.|::.|....  ..:.|..
Mouse   280 RRGWGEFPVRVQVHFKDS-QNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHS--LGEDSVY 341

  Fly   388 PHPPHEQETAVPAPPLAAPNVL---------EPSVFAFPGESCKPRTISITQNKE--ELDDNLFA 441
            |..........|.|.|..|..:         ||:..|..||.. |.|....::..  .|..:|..
Mouse   342 PQSSESDVCDAPPPTLTLPAAVKASAVAQSPEPAAAAPVGEGF-PETTEAERHSTFYSLPSSLER 405

  Fly   442 GINKIELSDDIE----------------KIEPTVLVSEPLKLNYSPRK--QP------------- 475
            ...|:..:..:.                ||.|...|..|    .||.|  ||
Mouse   406 TPTKVTTAQKVTFSSHGNSAFQPIASSCKIVPQSQVPNP----ESPGKSFQPITMSCKIVSGSPI 466

  Fly   476 --PTPSSPPRT------QLRLNAAQVTASKPSVVY--------------------LPVNGR---- 508
              |:||..|||      .|:...|....|.|.|:.                    |||..:
Mouse   467 STPSPSPLPRTPTSTPVHLKQGTASSGVSNPHVIVDKPGQVIGASTPSTGSPTSKLPVASQASQG 531

  Fly   509 --SP---------------RQESL-------------PERQ-----------------RQE---- 522
              ||               ::|||             |:.|                 :||
Mouse   532 TGSPIPKIHGSSFLTSTVKQEESLFASMPPLCPIGSHPKVQSPKAVTGGLGAFTKVIIKQEPGEA 596

  Fly   523 ----------------FSPVK--HYPPASPQR---AWKESSSDRPPIKP-----VPNG------- 554
                            :..||  |....|||:   :..|.::..|.|.|     ||.|
Mouse   597 PHVSTTGAASQSAFPQYVTVKGGHMIAVSPQKQVISAGEGTTQSPKIAPSKVVGVPVGSALPSTV 661

  Fly   555 ---------------------HHQGKKNVVFQRA------------------------------- 567
                                 ...|.|.||.|..
Mouse   662 KQAVAISSGQILVAKASSSVTKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKTQVTAAGPQ 726

  Fly   568 -------------------------------------------GKLYII---------------- 573
                                                       |||.:|
Mouse   727 KSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQS 791

  Fly   574 -------------------------------------------------------------DPL- 576
                                                                         .|.
Mouse   792 GSAAAGGSGSSGAGGGSGGGGGSGAGGTPSTSGPGGGPQHLTYTSYILKQTPQGTFLVGQPSPQT 856

  Fly   577 ------------------------QRKLK-----------QAAK--QQSLLK------------P 592
                                    |:.||           |||.  |.||||            |
Mouse   857 PGKQLTTASVVQGTLGVSSSSAQGQQTLKVISGQKTTLFTQAATAGQASLLKLPDNTLKSVPAAP 921

  Fly   593 QL---------------------------------------------SLLKPPSE---------- 602
            ||                                             |::|.|.:
Mouse   922 QLAKPGTTMLRVAGGVITAAPSPAVAFSANGAVHQSEGSTPVSSSVGSIIKTPGQPQVCVSQATM 986

  Fly   603 -----------TRWHMLQCMQHDHGYANMSGEM------------------EEKPM--------- 629
                       |...::.......|.|.:||.:                  :.||:
Mouse   987 ATCKGPAAVAGTAASLVSAPSSISGKATVSGLLKVHSAQSSPQQAVLTIPSQLKPLSINTSGGVQ 1051

  Fly   630 --LLP-------------------------------PIVDTTIQSRPRR---------------- 645
              |:|                               |:....:::.|..
Mouse  1052 TVLMPVNKVVQSFSTSKLPTTVLPISVPNQAAPSSAPVAIAKVKTEPETPGPNCISQENQVAVKT 1116

  Fly   646 ------LEHIFRSAQFRNMRSAVEFLLSRLPLASIDQQKEYPFTCITLEEFHNHTALKQRCFEYL 704
                  ..::.:......::..:..::.::||.:........|:..:||:::.....|:|..|:.
Mouse  1117 EESSELSNYVIKVDHLETIQQLLTAVVKKIPLITAKGDDASCFSAKSLEQYYGWNIGKRRAAEWQ 1181

  Fly   705 RARMLRRCLMQ-------HHELHKLDISGKEHYWSLREIVAFARVHGYTPALKDVLPVVHEKRKQ 762
            ||..:|:.|.:       .|.|..|         ..:.|..:.|.|||||      |.....|..
Mouse  1182 RAMTVRKVLQEILEKNPRFHHLTPL---------KTKHIAHWCRCHGYTP------PDPESLRHD 1231

  Fly   763 KLSDEEQLARRVQAQLKGEPQPQLSAYSSLSSGNRLEAWITKQSDRLLGHDQQMRDKEFIDVLGV 827
            ..|.|:     |..|:..||:    ..||.|:.:.|   ..|..|......::..::|.:|:|.:
Mouse  1232 GDSIED-----VLTQIDSEPE----CLSSFSTADDL---CRKLEDLQQFQKREPENEEEVDILSL 1284

  Fly   828 DKPHPLASRLTNSADVSFQMVNHRQLLYLPPPKHLDSTLQLVQEMCKDINITLEPEESPPGVSQP 892
            .:|      |..:.....:........||||.....    .|.::.:.|.|||:|......:...
Mouse  1285 SEP------LKTNIKKEQEEKQEEMRFYLPPTPGSG----FVGDITQKIGITLQPVALHRNMYAS 1339

  Fly   893 LALSMLGQVLRTFIEKLVRRSLAAKLQQETLEQLPPAAANAPLCLQPQDIGRVISLCSELDFLGN 957
            :...|:.:.....:..::|::||...|..:..::|..       :...:|.:.|.....||||.|
Mouse  1340 VVEDMILKATEQLVSDILRQALAVGYQTASPNRIPKE-------ITVSNIHQAICNIPFLDFLTN 1397

  Fly   958 SHLG 961
            .|:|
Mouse  1398 KHMG 1401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D12	NP_609228.2	YEATS_YEATS2_like	249..375	CDD:341126	59/125 (47%)
Yeats2	NP_001139402.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..196		16/104 (15%)
		YEATS_YEATS2_like	209..332	CDD:341126	60/126 (48%)
		Histone H3K27cr binding. /evidence=ECO:0000250|UniProtKB:Q9ULM3	260..262		1/1 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000250|UniProtKB:Q9ULM3	283..285		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	462..540		16/77 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..833		0/41 (0%)
		PRK07003	<887..>1123	CDD:235906	25/235 (11%)