Protein Alignment D12 and yeats2

DIOPT Version :10

• Sequence 1: NP_609228.2
• Gene: D12 / 34172
• FlyBaseID: FBgn0027490
• Length: 969
• Species: Drosophila melanogaster
• Sequence 2: XP_002660941.4
• Gene: yeats2 / 100320774
• ZFINID: ZDB-GENE-081104-292
• Length: 1419
• Species: Danio rerio
• Alignment Length: 1522
• Identity: 274/1522 - (18%)
• Similarity: 456/1522 - (29%)
• Gaps: 687/1522 - (45%)

  Fly    12 RRHSEYHDPDYQQ-TEVS----SQDEEETCAEAESPGQRKWTKTEQSDGMLPLSDKFQRIRELLR 71
            :|..|..||||:. |:|.    |:..|:...:|                      ..|:|..:::
Zfish     5 KRKIEDKDPDYEDITQVQENKRSRVVEQNARDA----------------------AVQKIDAIIK 47

  Fly    72 LEFQREISQKVEQLAEIDRRLLQGRQLLDRLRYQVVSEYYRKQQVPLTGADIAKVRGDSLFGDDI 136
            .:|..|:..|..::..|.:||.:.|:::|:||..:|:.||.....|       ||..::...|
Zfish    48 DQFSLEMKSKEHEIEVIGQRLNEARRMMDKLRACIVANYYASAGQP-------KVLPEASKSD-- 103

  Fly   137 AAPQLPLHPAIKKIVGKRPVVIQNHLPERTAATLAKETIRLRNPAHRRAERRRQQKIKEQGIV-- 199
              |.:..|||||:.:..         |.|:::.|.:.:   ..|:..::|   .:.:.:||..
Zfish   104 --PSVLNHPAIKRFLDS---------PSRSSSPLNQNS---DTPSQVQSE---TESLSQQGEAGE 151

  Fly   200 --TDHSKDKKDQPEQEP-----------PISVKLEDEQPCTSRQAHERQVELNASRLNNKNKFNF 251
              ||..::.....|:.|           |.|:    ||..|.....:     :||||..|.  ..
Zfish   152 RETDSGREDGTPRERRPGRNTGKDTFGVPSSI----EQHVTYHTTGD-----DASRLYMKK--TI 205

  Fly   252 VVGNTSKYIGEDSRENGTGGNALTYKWLVYVQGKDLPEPLEKYIKKVRFHLHPSYRPNDIVDVHR 316
            ||||.||||..|.||.   .:..|:||:|||:|......::.::|||.|.|||||:|||:|:|..
Zfish   206 VVGNVSKYIAPDKREE---NDQSTHKWMVYVRGSRKEPSIDHFVKKVWFFLHPSYKPNDLVEVSE 267

  Fly   317 SPFQLNRHGWGEFPMRIQLFFQEHLQQKPVQLMHTVVLDKTMCGLHTMGAETTVEIWL------- 374
            .||.|.|.||||||:|:|:.|::. :.|.:.::|.:.||:|..||.|:||||.|::.|
Zfish   268 PPFHLTRRGWGEFPVRVQIHFKDQ-RNKRIDIIHHLKLDRTYTGLQTLGAETVVDVQLYRNSLGD 331

  Fly   375 ------------------------RAKQAI--TKQKSGKPHPPHE------------QETAVPA- 400
                                    .:...|  :::.|...||.|:            .|:..|:
Zfish   332 DFIPSAPSSSSSSSSYPAFVGGSGSSSSTIHGSRRNSSPSHPAHDDQHSSERGVTVKSESVRPSC 396

  Fly   401 -----------------------PPLAA-----PNVLEPSVFAFPGE--------SCK------- 422
                                   .|:.:     |....||....||:        |||
Zfish   397 LEQTSQSNRSEKITLGSHGNSAFQPITSSCKIIPQGQVPSAAESPGKSSFQPITMSCKIVSGSPI 461

  Fly   423 --------PRTISIT----QNKEELDDNLFAGINK----IELSDD-------------------- 451
                    |||.|.|    ::...:.:|.:..::|    |.::..
Zfish   462 STPSHSPLPRTSSSTPVHMKSSPSVINNPYIIVDKPGQVINMAASSSAATGSPAKHSSTAHGARS 526

  Fly   452 -----------------IEKIEPTVLVSEPL------------------------KLNYSPRKQP 475
                             |.|.||..:.::|.                        .:..||:||.
Zfish   527 PAPKVHTSSFLSSGVKVIIKQEPGEVPTQPSPQQQVVSTSASQQQQQYVTVKGGHMIAMSPQKQS 591

  Fly   476 -------PTPS-------SPPRTQLRLNAAQVTASK--PSV------------------------ 500
                   .|||       .....|:.:::.|:..:|  |||
Zfish   592 GGGAGGVATPSKVLGIPLGSAVKQVSMSSGQILVAKSSPSVSKVVGQKQVVAQGVAKAIVSGGGS 656

  Fly   501 --------------------------------------------------VYLPVNGRSPRQE-- 513
                                                              :||..|.::|..:
Zfish   657 GTSGVVGQQVHVGTKAASGSGGGGKSGVMATLQLPANNLANLANLPPGTKLYLTTNSKNPSGKGK 721

  Fly   514 --------------------------------------SLPERQRQEFSPVKHYPPAS-----PQ 535
                                                  |||.........:|..|..:     |.
Zfish   722 LLLIPQGAILRASHSAGQQSQSSGSGGSHSSSGSSGSGSLPSNLSYTSYILKQTPQGTFLVGQPG 786

  Fly   536 RAWKESSSDRPPIKPVPNGHHQGKKNVVFQRA---------------GKLYIIDPLQRKLKQAAK 585
            .:.|:||.......|. :|..|..:....|:|               |....:.....|:..||.
Zfish   787 GSGKQSSGGHVASSPA-SGTQQAIRVTAGQKAAILAQVCNKVVGGSQGSQVKLSDGSVKMVTAAA 850

  Fly   586 QQSLLKPQLSLLK--------------PPSETRWHM----------------------------- 607
            ...|.||..:.|:              .||.|....
Zfish   851 ASHLNKPGTTTLRMTGGVITATSSTPTTPSATPTSQQSAEATGGSSSQQLPQTAKAPPHHPVLVA 915

  Fly   608 --------------------------------------LQCMQHDHGYANMSGEMEEKPMLL--- 631
                                                  |..:....|.:.:||.....|.|:
Zfish   916 ANQAAVISAAKSASSAANTKTASSAGAVVTVAKSVNMPLISLPKGAGPSAVSGAKSSSPSLVTAA 980

  Fly   632 ----------------------------------------------------------------- 631
                                                                             
Zfish   981 SLIGGGTVSGKTAATISGMLKLHPAQSSSQQTVLTIPANQLKQLSVGSGSSGLQTILMPVGKVVQ 1045

  Fly   632 ------------------------------PPIVDTT---------------------------- 638
                                          |.:|.:|
Zfish  1046 SGSKGTSSNNSTPSGAASSASTAIAQVKTEPGLVSSTCTTPVPQTSAPTSAAPASAPLPTAPTST 1110

  Fly   639 -----------IQSRPRRL---EHIFRSAQFRNMRSAVEFLLSRLPLASIDQQKE-YPFTCITLE 688
                       ::|....|   |||      .||...:..::.:.||...::.:: :||...:::
Zfish  1111 DAAATVKVEQGLESTTHELINTEHI------ENMTQLLTAIVKKFPLIVPEKNEDSHPFCATSVD 1169

  Fly   689 EFHNHTALKQRCFEYLRARMLRR-C---LMQHHELHKLDISGKEHYWSLREIVAFARVHGYTPAL 749
            ::::....|:|..|..||..:|| |   |.:...|..|..:      ..:|::.:.|:.||||
Zfish  1170 QYYSWNIGKRRAAELQRAVAVRRVCADLLERTPRLQALTPA------RTKEVLRWCRLRGYTP-- 1226

  Fly   750 KDVLPVVHEKRKQKLSDEEQLARRVQAQLKGEPQ--PQLSAYSSLSSGNRLEAWITKQSDRLLGH 812
                |....:|.::.|.|:     :..|:..||:  ..|:....||  .|||     |..|:|..
Zfish  1227 ----PDPEPQRTEEDSIED-----ILTQIDSEPECSSTLTGCEELS--QRLE-----QLQRILKA 1275

  Fly   813 DQQMRDKEFIDVLGVDKPHPLASRLTNSADVSFQMVNHRQLLYLPPPK----HLDSTLQLVQEMC 873
            :....|.|.:|::.|           ...|.....:...|......||    ...|| ||:::..
Zfish  1276 EPDEEDDELLDIISV-----------KELDAGKVKIKQEQEEAEQEPKFYMGRCPST-QLIRDTA 1328

  Fly   874 KDINITLEPEESPPGVSQPLALSMLGQVLRTFIEKLVRRSLA---AKLQQETLEQLPPAAANAPL 935
            :.|.:||:..|....|..|:..:|:.:.:..|..:::|.|||   .|.||.          ..|.
Zfish  1329 EQIGVTLQQVEVEKNVFAPVVEAMILKAVEQFSSEILRESLANAHGKSQQN----------RTPR 1383

  Fly   936 CLQPQDIGRVISLCSELDFLGNSHLGV 962
            .:...::.:.|......|||.|.::|:
Zfish  1384 EISAMNVHQAICSIPTCDFLTNRYMGI 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D12	NP_609228.2	YEATS_YEATS2_like	249..375	CDD:341126	59/156 (38%)
yeats2	XP_002660941.4	None