DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grk and Nrg1

DIOPT Version :9

Sequence 1:	NP_476568.2	Gene:	grk / 34171	FlyBaseID:	FBgn0001137	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	XP_006509122.1	Gene:	Nrg1 / 211323	MGIID:	96083	Length:	884	Species:	Mus musculus

Alignment Length:	181	Identity:	45/181 - (24%)
Similarity:	76/181 - (41%)	Gaps:	25/181 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 NRLELQRKQLEASAQEE--ADQLHPDTDPNPDSGGQLPNADDSIAADPEQDGIILGSSTD--TWL 128
            |.|..:.|......|::  ..:|..:.....|||..:......:..|.....|.:..|.|  |.:
Mouse   288 NELNRRNKPQNVKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNDLTTGM 352

  Fly   129 ASESSTPITDSETVTTPETVTHTGEPPPDPSSSSTPDSTTPSPNDKETEIQMLPCSEAYNTSFCL 193
            ::.:..|...||:.......|....     :||||..|||.:.:       ::.|:|...| ||:
Mouse   353 SASTERPYVSSESPIRISVSTEGAN-----TSSSTSTSTTGTSH-------LIKCAEKEKT-FCV 404

  Fly   194 NGGHCFQHPMVNNTVFHSCLCVNDYDGERCAYKSWNGDYIYSP--PTAQRK 242
            |||.||....::|...:.|.|.|::.|:||.      :|:.:.  .|::||
Mouse   405 NGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ------NYVMASFYMTSRRK 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grk	NP_476568.2	None
Nrg1	XP_006509122.1	Ig_Pro_neuregulin-1	266..340	CDD:143303	9/51 (18%)
		EGF	403..433	CDD:333761	11/29 (38%)
		Neuregulin	511..866	CDD:366946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910