DRSC/TRiP Functional Genomics Resources

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Protein Alignment IDH1 and IDP3

DIOPT Version :10

Sequence 1:NP_005887.2 Gene:IDH1 / 3417 HGNCID:5382 Length:414 Species:Homo sapiens
Sequence 2:NP_014389.3 Gene:IDP3 / 855723 SGDID:S000004954 Length:420 Species:Saccharomyces cerevisiae


Alignment Length:398 Identity:241/398 - (60%)
Similarity:306/398 - (76%) Gaps:4/398 - (1%)


- Green bases have known domain annotations that are detailed below.


Human    10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCA 74
            :|||.|||.||:||:|||||||.||:::||..|||.|:.||.||||||||::.|..|:.|.||||
Yeast    10 IVEMDGDEQTRVIWKLIKEKLILPYLDVDLKYYDLSIQERDRTNDQVTKDSSYATLKYGVAVKCA 74

Human    75 TITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQY 139
            ||||||.|::||.||:||||||||||||||||||||.||...|||||..|.|||||||||:||||
Yeast    75 TITPDEARMKEFNLKEMWKSPNGTIRNILGGTVFREPIIIPKIPRLVPHWEKPIIIGRHAFGDQY 139

Human   140 RATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKG 204
            ||||..:...||:.:.::..||.:.:...|:.|.:.||:||.|:|.:.||:.||.:||::||.:.
Yeast   140 RATDIKIKKAGKLRLQFSSDDGKENIDLKVYEFPKSGGIAMAMFNTNDSIKGFAKASFELALKRK 204

Human   205 WPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
            .||:.:|||||||.||.:||.||..::||:||.:|:|.||.||||||||||||.:||:||||.|.
Yeast   205 LPLFFTTKNTILKNYDNQFKQIFDNLFDKEYKEKFQALKITYEHRLIDDMVAQMLKSKGGFIIAM 269

Human   270 KNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIF 334
            ||||||||||.||||:||||:|||:|:.|||||.|:||||||||||:|.:|:|:|||||.|||||
Yeast   270 KNYDGDVQSDIVAQGFGSLGLMTSILITPDGKTFESEAAHGTVTRHFRKHQRGEETSTNSIASIF 334

Human   335 AWTRGLAHRAKLDNNKELAFFANALEEVSIETIE-AGFMTKDLAACIKGLPNVQRSDYLNTFEFM 398
            ||||.:..|.||||..::..|.|.||:.:::|:: .|.||||||..   |....||.|:.|.||:
Yeast   335 AWTRAIIQRGKLDNTDDVIKFGNLLEKATLDTVQVGGKMTKDLALM---LGKTNRSSYVTTEEFI 396

Human   399 DKLGENLK 406
            |::.:.|:
Yeast   397 DEVAKRLQ 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IDH1NP_005887.2 PTZ00435 1..411 CDD:240417 241/398 (61%)
IDP3NP_014389.3 PRK08299 1..407 CDD:236226 241/398 (61%)

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