DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IDH1 and IDP2

DIOPT Version :10

Sequence 1:NP_005887.2 Gene:IDH1 / 3417 HGNCID:5382 Length:414 Species:Homo sapiens
Sequence 2:NP_013275.1 Gene:IDP2 / 850871 SGDID:S000004164 Length:412 Species:Saccharomyces cerevisiae


Alignment Length:415 Identity:252/415 - (60%)
Similarity:308/415 - (74%) Gaps:4/415 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIK 65
            |:|......:|||.|||.|||||.||::||:.||:::||..|||.:|.||.||||||.|:|.|..
Yeast     1 MTKIKVANPIVEMDGDEQTRIIWHLIRDKLVLPYLDVDLKYYDLSVEYRDQTNDQVTVDSATATL 65

Human    66 KHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIII 130
            |:.|.||||||||||.|||||.||:||||||||||||||||||||.||...|||||..|.|||||
Yeast    66 KYGVAVKCATITPDEARVEEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRLVPQWEKPIII 130

Human   131 GRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
            ||||:||||:|||.:||..|::.:.|....||..|...|.::.|.|||||.|||...|||.||.:
Yeast   131 GRHAFGDQYKATDVIVPEEGELRLVYKSKSGTHDVDLKVFDYPEHGGVAMMMYNTTDSIEGFAKA 195

Human   196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMK 260
            ||::|:.:..|||.:|||||||||||:|||:|:.:|.:.||.:||:..||||||||||||||.:|
Yeast   196 SFELAIERKLPLYSTTKNTILKKYDGKFKDVFEAMYARSYKEKFESLGIWYEHRLIDDMVAQMLK 260

Human   261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQET 325
            |:||:|.|.|||||||:||.||||:||||:|||||:.|||||.|:||||||||||:|.:|:|:||
Yeast   261 SKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHFRQHQQGKET 325

Human   326 STNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETI-EAGFMTKDLAACIKGLPNVQRS 389
            |||.||||||||||:..|.||||..::..|...||..::.|: |.|.||||||..   |...:||
Yeast   326 STNSIASIFAWTRGIIQRGKLDNTPDVVKFGQILESATVNTVQEDGIMTKDLALI---LGKSERS 387

Human   390 DYLNTFEFMDKLGENLKIKLAQAKL 414
            .|:.|.||:|.:...||.:...|.|
Yeast   388 AYVTTEEFIDAVESRLKKEFEAAAL 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IDH1NP_005887.2 PTZ00435 1..411 CDD:240417 250/410 (61%)
IDP2NP_013275.1 nadp_idh_euk 2..409 CDD:129233 249/409 (61%)

Return to query results.
Submit another query.