Protein Alignment IDH1 and idh1

DIOPT Version :10

• Sequence 1: NP_005887.2
• Gene: IDH1 / 3417
• HGNCID: 5382
• Length: 414
• Species: Homo sapiens
• Sequence 2: XP_012825747.1
• Gene: idh1 / 448164
• XenbaseID: XB-GENE-1004994
• Length: 415
• Species: Xenopus tropicalis
• Alignment Length: 410
• Identity: 363/410 - (88%)
• Similarity: 389/410 - (94%)
• Gaps: 0/410 - (0%)

Human     1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIK 65
            |||||:||||||||||||||:||:|||||||.||||||||.|||||||||||:||||.|||||||
 Frog     1 MSKKINGGSVVEMQGDEMTRVIWDLIKEKLILPYVELDLHCYDLGIENRDATDDQVTVDAAEAIK 65

Human    66 KHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIII 130
            |:|||:|||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
 Frog    66 KYNVGIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIII 130

Human   131 GRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
            ||||||||||||||||||||||||::||.||.:.:.|::||||:.||||:||||.|:||.|||||
 Frog   131 GRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAIKYVIHNFEDCGGVALGMYNTDQSIRDFAHS 195

Human   196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMK 260
            ||||||||.||||:||||||||||||||||||||||:|.||||||.:||||||||||||||||||
 Frog   196 SFQMALSKSWPLYMSTKNTILKKYDGRFKDIFQEIYEKDYKSQFEEKKIWYEHRLIDDMVAQAMK 260

Human   261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQET 325
            |||||||||||||||||||||||||||||||||||:||||||||||||||||||||||:||||||
 Frog   261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMHQKGQET 325

Human   326 STNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD 390
            |||||||||||||||.||||||||:||..||..||||.:||||||||||||||||||||||||:|
 Frog   326 STNPIASIFAWTRGLDHRAKLDNNQELKNFATTLEEVCVETIEAGFMTKDLAACIKGLPNVQRAD 390

Human   391 YLNTFEFMDKLGENLKIKLA 410
            ||:||||||||.|||::|||
 Frog   391 YLSTFEFMDKLAENLQLKLA 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDH1	NP_005887.2	PTZ00435	1..411	CDD:240417	363/410 (89%)
idh1	XP_012825747.1	PTZ00435	1..411	CDD:240417	363/410 (89%)