DRSC/TRiP Functional Genomics Resources

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Protein Alignment IDH1 and Idh

DIOPT Version :10

Sequence 1:NP_005887.2 Gene:IDH1 / 3417 HGNCID:5382 Length:414 Species:Homo sapiens
Sequence 2:NP_001137910.2 Gene:Idh / 44291 FlyBaseID:FBgn0001248 Length:479 Species:Drosophila melanogaster


Alignment Length:412 Identity:297/412 - (72%)
Similarity:357/412 - (86%) Gaps:3/412 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIK 65
            |::||..|.||::.|||||||||:.||.:||.|:::::||:|||||||||.|.||||.|.|||||
  Fly    64 MAQKIKAGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIK 128

Human    66 KHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIII 130
            |:|||:|||||||||||||||.||:||||||||||||||||||||||||||:||||:||.|||:|
  Fly   129 KYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVI 193

Human   131 GRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
            ||||:.|||:|.|:|||||||:.:|:..:|| |.:..::::| :|.|:|:||:|.|.||.||||:
  Fly   194 GRHAHADQYKAVDYVVPGPGKLTLTWKGTDG-QVIDEVINDF-KGPGIALGMFNTDDSIVDFAHA 256

Human   196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMK 260
            ||:.||.:..|||:||||||||||||||||||:::|:||||.::||..|||||||||||||.|||
  Fly   257 SFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMK 321

Human   261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQET 325
            |||||:|||||||||||||||||||||||:|||||:|||||||||||||||||||:|.||:|:||
  Fly   322 SEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKET 386

Human   326 STNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPN-VQRS 389
            |||||||||||||||.||||||||:.|..||:.||:|.|:|||:|.||||||.||||..| |.|.
  Fly   387 STNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRR 451

Human   390 DYLNTFEFMDKLGENLKIKLAQ 411
            ||..||||::.|.:||:..||:
  Fly   452 DYQETFEFINTLAKNLEGALAK 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IDH1NP_005887.2 PTZ00435 1..411 CDD:240417 296/410 (72%)
IdhNP_001137910.2 PTZ00435 63..474 CDD:240417 297/412 (72%)

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