Protein Alignment IDH1 and idp1

DIOPT Version :10

• Sequence 1: NP_005887.2
• Gene: IDH1 / 3417
• HGNCID: 5382
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_594105.2
• Gene: idp1 / 2542598
• PomBaseID: SPAC6G10.08
• Length: 439
• Species: Schizosaccharomyces pombe
• Alignment Length: 401
• Identity: 262/401 - (65%)
• Similarity: 314/401 - (78%)
• Gaps: 7/401 - (1%)

Human    10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCA 74
            ||||.||||||:||::|:|||:.||:::.|..||||||.||.||||:|.|||:||.|::||:|||
pombe    41 VVEMDGDEMTRVIWKIIREKLVLPYMDIKLDYYDLGIEARDKTNDQITVDAAKAILKNDVGIKCA 105

Human    75 TITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQY 139
            ||||||.||:|:.||:|||||||||||||.||||||.|:.||||:.:.||..||.|||||:||||
pombe   106 TITPDEARVKEYNLKKMWKSPNGTIRNILNGTVFREPILIKNIPKYIPGWTNPICIGRHAFGDQY 170

Human   140 RATDFVVPGPGKVEITYTP-SDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
            ::||.|..||||:|:::|| .:.:.|.||.|:.| .|.||||.|||.|.||..||||||||||.|
pombe   171 KSTDLVASGPGKLELSFTPKGNPSAKETYNVYEF-NGSGVAMSMYNTDDSIRGFAHSSFQMALQK 234

Human   204 GWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWA 268
            ..||||||||||||||||||||.|||:|:..||.:||...:||:|||||||||||:||.|||:||
pombe   235 KMPLYLSTKNTILKKYDGRFKDTFQEVYESDYKQKFEELGLWYQHRLIDDMVAQAIKSNGGFVWA 299

Human   269 CKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASI 333
            ||||||||.||.|||.|||||:|||||:.|:|:|.|:|||||||.|||..|.||::||||.||||
pombe   300 CKNYDGDVMSDVVAQAYGSLGLMTSVLIHPNGRTFESEAAHGTVQRHYMQYLKGKKTSTNSIASI 364

Human   334 FAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFM 398
            ||||||||||.:||.|:.|..||||||...:..:|.|.|||||....|. ||    .|::||||:
pombe   365 FAWTRGLAHRGRLDGNERLVKFANALEHACVRCVEKGIMTKDLYLLSKS-PN----GYVDTFEFL 424

Human   399 DKLGENLKIKL 409
            |.:...|..:|
pombe   425 DAVKSELDSEL 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDH1	NP_005887.2	PTZ00435	1..411	CDD:240417	262/401 (65%)
idp1	NP_594105.2	PTZ00435	31..435	CDD:240417	261/399 (65%)