DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IDH1 and idh-1

DIOPT Version :10

Sequence 1:NP_005887.2 Gene:IDH1 / 3417 HGNCID:5382 Length:414 Species:Homo sapiens
Sequence 2:NP_001255392.1 Gene:idh-1 / 177775 WormBaseID:WBGene00010317 Length:435 Species:Caenorhabditis elegans


Alignment Length:411 Identity:310/411 - (75%)
Similarity:353/411 - (85%) Gaps:4/411 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     2 SKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKK 66
            ::||.||.:|||||||||||||:|||||||.|||:|::|.:|||||:||||:||||.|||.|..|
 Worm    26 AQKIQGGDIVEMQGDEMTRIIWDLIKEKLILPYVDLNVHFFDLGIEHRDATDDQVTIDAANATLK 90

Human    67 HNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIG 131
            :||.||||||||||.||||||||:||||||||||||||||||||.||.||:||||:.|.||||||
 Worm    91 YNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRLVNTWSKPIIIG 155

Human   132 RHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSS 196
            |||:.|||:||||||||.||:||.:..:||||.:...|.:| :|.||::.|||.|.||.||||:|
 Worm   156 RHAHADQYKATDFVVPGAGKLEIKFVSADGTQTIQETVFDF-KGPGVSLSMYNTDDSIRDFAHAS 219

Human   197 FQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKS 261
            |:.||.:.:||||||||||||||||||||||.||| .:|:::|:|..||||||||||||||||||
 Worm   220 FKYALQRKFPLYLSTKNTILKKYDGRFKDIFAEIY-PEYEAEFKAAGIWYEHRLIDDMVAQAMKS 283

Human   262 EGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETS 326
            :|||:|||||||||||||||||||||||:||||||||||||||||||||||||||||:|||||||
 Worm   284 DGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPDGKTVEAEAAHGTVTRHYRMHQKGQETS 348

Human   327 TNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKG--LPNVQRS 389
            ||||||||||:|||||||.||.|..|..|||.||.|.|||:||||:|||||.|:||  ...|.|:
 Worm   349 TNPIASIFAWSRGLAHRATLDKNSALETFANNLEAVCIETMEAGFLTKDLAICVKGGNASAVTRT 413

Human   390 DYLNTFEFMDKLGENLKIKLA 410
            ||||||||:|||.|||..|.|
 Worm   414 DYLNTFEFLDKLAENLAKKQA 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IDH1NP_005887.2 PTZ00435 1..411 CDD:240417 310/411 (75%)
idh-1NP_001255392.1 PTZ00435 27..432 CDD:240417 308/406 (76%)

Return to query results.
Submit another query.