DRSC/TRiP Functional Genomics Resources

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Protein Alignment IDH1 and idh1

DIOPT Version :10

Sequence 1:NP_005887.2 Gene:IDH1 / 3417 HGNCID:5382 Length:414 Species:Homo sapiens
Sequence 2:NP_958907.1 Gene:idh1 / 100006589 ZFINID:ZDB-GENE-031006-1 Length:429 Species:Danio rerio


Alignment Length:415 Identity:343/415 - (82%)
Similarity:383/415 - (92%) Gaps:1/415 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIK 65
            ||:|:..|||||||||||||:|||||||||||||:||||||||||:||||||:|:||.:||||::
Zfish    15 MSQKVKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVR 79

Human    66 KHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIII 130
            ::|||:|||||||||||||||||||||:||||||||||||||||||||||||||||.||:|||||
Zfish    80 RYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWIKPIII 144

Human   131 GRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
            ||||:||||:||||||||||.||:||.|.:|.:.:.::||:||..||||:||||.||||.|||||
Zfish   145 GRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVALGMYNTDKSIRDFAHS 209

Human   196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMK 260
            ||||.|:||||:||||||||||||||||||||||||||:||:::||..|||||||||||||||||
Zfish   210 SFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYEAMGIWYEHRLIDDMVAQAMK 274

Human   261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQET 325
            ||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||:|:|:||
Zfish   275 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGRTVEAEAAHGTVTRHYRMHQQGKET 339

Human   326 STNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD 390
            |||||||||||||||.|||:||.|.||..||.|||.|.:|||||||||||||.||||:..|.|||
Zfish   340 STNPIASIFAWTRGLLHRAELDKNAELRVFAEALEVVCVETIEAGFMTKDLAICIKGMSGVTRSD 404

Human   391 YLNTFEFMDKLGENLKIKL-AQAKL 414
            |||||||:|||.||||||| :|.||
Zfish   405 YLNTFEFLDKLAENLKIKLSSQPKL 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IDH1NP_005887.2 PTZ00435 1..411 CDD:240417 340/410 (83%)
idh1NP_958907.1 PTZ00435 15..424 CDD:240417 339/408 (83%)

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