DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13398 and dok1b

DIOPT Version :9

Sequence 1:	NP_001260252.1	Gene:	CG13398 / 34169	FlyBaseID:	FBgn0032042	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_998253.1	Gene:	dok1b / 406361	ZFINID:	ZDB-GENE-040426-2063	Length:	575	Species:	Danio rerio

Alignment Length:	471	Identity:	106/471 - (22%)
Similarity:	162/471 - (34%)	Gaps:	123/471 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RGHENVFRVRVAHLQPTPGTPIIRSGYLELTPRELIFQSPGCEP--IVWALQHLRRYGLNNDLFS 76
            |...|.|.|.|...:.:....:..:.:|......||.:.|..:.  ::|..:.|||||.:..:||
Zfish   145 REEVNEFLVTVQRTEASERCGLSGNYWLRANMDNLILKDPKTKKDLLIWPYKLLRRYGRDRVMFS 209

  Fly    77 FEAGRRCMSGPGIYTFRVHNAEQLYPMFQRYINAVNTDAFVQGERERVNSAHSV--------SVN 133
            |||||||.||||.:||......:::.:.:..|......|     .||..|..|:        .:.
Zfish   210 FEAGRRCESGPGNFTFETKQGNEIFHIVEESIREQKAQA-----EERHQSCPSLDSDCPALQQIR 269

  Fly   134 MGRTEGNNYLEPAPLMSRQLGNFHSEPSSTSASYPLQANDSQ-------------VDDSPPNLQS 185
            ...:|.|: .||    ....|.  |:|.|....:..:.||.:             |..:||  :|
Zfish   270 AAISEANS-REP----DGDSGG--SKPGSADGVFGRKENDGKNLKVRSLPEPPPPVGGTPP--RS 325

  Fly   186 PVLIPSAYLDQPLRALQDCCLEGTASDLLSTPPS-GNRLTS----RRRTMDLPPLESAPAPAPVL 245
            |  :|....:|   ..:...|....:|.:..||| |:.|.|    ..:.|.||.....||.....
Zfish   326 P--MPRGSKNQ---LDEQASLYSEPADSVRAPPSLGDCLYSDPVDSIKVMPLPNSRIRPAGEEGG 385

  Fly   246 SPNDAVH---MYANV-EALIFDLNNERCYENVNRLELPLLPREPISN-------QEPATPTSLAG 299
            |.|.::.   .|::: :.:..||     .:....|.|....|.|...       .||      .|
Zfish   386 SHNQSMKPDPFYSDIYDQISLDL-----IQKTMALGLDGRSRHPADGGPTEHIYDEP------EG 439

  Fly   300 SCGVNYIVLDL-------------------------DQPRSPVGPAGSSKAINGFGSGLSLISTP 339
            ..|.:..|:.|                         .||.....|.|                 |
Zfish   440 RAGSSQPVITLYDEARLDAHSWRNRAREESQCQEMAQQPLPMARPKG-----------------P 487

  Fly   340 AAVTAPVTPEAGTTLDVPPPPMQTQSLNSISADTGDTQAKKVTECSGTQGYSTIDFIRTYALNKS 404
            ..||||...:.......||||.|.:.    ||:..:..:.|        .|..::..|..|...:
Zfish   488 KPVTAPKPGKVSLGKKEPPPPPQIKG----SANLNNNNSSK--------RYDNMEAGRRDAGAGN 540

  Fly   405 STELPETVTHRQHSSH 420
            :.||...|:..|..|:
Zfish   541 NMELYSKVSRHQPPSN 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13398	NP_001260252.1	PTB_FRS2	15..109	CDD:269913	29/95 (31%)
dok1b	NP_998253.1	PH	5..114	CDD:278594
		PH_DOK1,2,3	6..116	CDD:270195
		PTB_DOK1_DOK2_DOK3	147..245	CDD:269914	30/97 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574611
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930