DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13398 and Dok1

DIOPT Version :9

Sequence 1:	NP_001260252.1	Gene:	CG13398 / 34169	FlyBaseID:	FBgn0032042	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_001020587.1	Gene:	Dok1 / 312477	RGDID:	1309499	Length:	480	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	99/385 - (25%)
Similarity:	138/385 - (35%)	Gaps:	125/385 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GTPIIRSGYLELTPRELIFQSPGCEPIV-WALQHLRRYGLNNDLFSFEAGRRCMSGPGIYTFRVH 95
            |:.::|....:||...|..||...||:: |....|||||.:..:|||||||||.||||.:||:..
  Rat   172 GSYVLRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTA 236

  Fly    96 NAEQLYPMFQRYINAVNTDAFV-QGERERVNSAHSVSVNMGRTEGNNYLEPAPLMSRQLGNFHSE 159
            ....::...:..|........| ||:......:|.     |.|||.  :.|.|:....||
  Rat   237 QGNDIFQAVEAAIQQQKAQGKVGQGQDITRTDSHD-----GETEGK--MAPTPVPQEPLG----- 289

  Fly   160 PSSTSASYPLQANDSQVDDSPPNLQSPVLIPSAYLDQPLRALQDCCLEGTASDLLSTPPSGNRLT 224
                               |||.|.:          :||.:|:           :...||.:.|.
  Rat   290 -------------------SPPALYA----------EPLDSLR-----------IPPGPSQDSLY 314

  Fly   225 SRRRTMDLPPLESAPAPAPVLSPNDAVHMYANVEALIFDLNNERCYENVNR--LELPLL--PREP 285
            |       .||.|.||.|     .:.|.   ..:.|.:||     |.:|.:  |:..|:  ..:|
  Rat   315 S-------DPLGSTPAGA-----GEGVQ---RKKPLYWDL-----YGHVQQQLLKTKLIDSKEDP 359

  Fly   286 ISNQ-EPATPTSLAGSCGVNYIVLDLDQ-PRS---------------PVGPAGSSKAINGFGSGL 333
            |.:: |...|..|.|       :.||.| |:.               |..||....|:....|
  Rat   360 IYDEPEGLAPAPLRG-------LYDLPQEPKDAWWCQARLKEEGYELPYNPATDDYAVPPPRS-- 415

  Fly   334 SLISTPAAVTAP---VTPEAGTTLDVPPPPMQTQSLNSISADTG-DTQAKKVTECSGTQG 389
               |.|.....|   :.||:|||..              |...| ||......:.|||.|
  Rat   416 ---SKPTPAPKPQGLILPESGTTAG--------------SGSKGSDTALYSQVQKSGTPG 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13398	NP_001260252.1	PTB_FRS2	15..109	CDD:269913	30/77 (39%)
Dok1	NP_001020587.1	PH-like	6..119	CDD:418428
		PTB_DOK1_DOK2_DOK3	151..253	CDD:269914	31/80 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..328		29/138 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..480		21/80 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.700