DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13398 and DOK1

DIOPT Version :9

Sequence 1:	NP_001260252.1	Gene:	CG13398 / 34169	FlyBaseID:	FBgn0032042	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_001372.1	Gene:	DOK1 / 1796	HGNCID:	2990	Length:	481	Species:	Homo sapiens

Alignment Length:	382	Identity:	92/382 - (24%)
Similarity:	130/382 - (34%)	Gaps:	119/382 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KLNELRGHEN---------------VFRVRVAHLQPTPGTPIIRSGYLELTPRELIFQSPGCEPI 58
            ||:.|...||               |.|...|......|:.::|.....||...:..||...||:
Human   134 KLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPL 198

  Fly    59 V-WALQHLRRYGLNNDLFSFEAGRRCMSGPGIYTFRVHNAEQLYPMFQRYINAVNTDAFVQGERE 122
            : |....|||||.:..:|||||||||.||||.:||:......::       .||.|....|..:.
Human   199 LSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIF-------QAVETAIHRQKAQG 256

  Fly   123 RVNSAHSVSVNMGRTEGNNYLEPAPLMSRQLGNFHSEPSSTSASYPLQANDSQVDDSPPNLQSPV 187
            :....|.|.    |.:.:                  |........|......::.||||.|.:
Human   257 KAGQGHDVL----RADSH------------------EGEVAEGKLPSPPGPQELLDSPPALYA-- 297

  Fly   188 LIPSAYLDQPLRALQDCCLEGTASDLLSTPPSGNRLTSRRRTMDLPPLESAPAPAPVLSPNDAVH 252
                    :||.:|:           ::..||.:.|.|       .||:|..|.|     .:.|.
Human   298 --------EPLDSLR-----------IAPCPSQDSLYS-------DPLDSTSAQA-----GEGVQ 331

  Fly   253 MYANVEALIFDLNNERCYENVNR--LELPLL-PRE-PISNQ----EPATPTSLAGSCGVNYIVLD 309
               ..:.|.:||     ||:..:  |:..|. |:| ||.::    .|..|..|
Human   332 ---RKKPLYWDL-----YEHAQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGL------------ 376

  Fly   310 LDQPRSPVGPAGSSKAINGFGSGLSLISTPAAVTAPVTPEAGTTLDVPPPPMQTQSL 366
            .|.||.|.........:.  ..|..|...||.....|           |||..|:.|
Human   377 YDLPREPKDAWWCQARVK--EEGYELPYNPATDDYAV-----------PPPRSTKPL 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13398	NP_001260252.1	PTB_FRS2	15..109	CDD:269913	34/109 (31%)
DOK1	NP_001372.1	PH-like	6..119	CDD:327399
		PTB_DOK1_DOK2_DOK3	151..253	CDD:269914	35/108 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..293		4/40 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..329		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..481		8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5513
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.820