DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13398 and Dok1

DIOPT Version :9

Sequence 1:	NP_001260252.1	Gene:	CG13398 / 34169	FlyBaseID:	FBgn0032042	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_034200.4	Gene:	Dok1 / 13448	MGIID:	893587	Length:	482	Species:	Mus musculus

Alignment Length:	392	Identity:	101/392 - (25%)
Similarity:	143/392 - (36%)	Gaps:	122/392 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GTPIIRSGYLELTPRELIFQSPGCEPIV-WALQHLRRYGLNNDLFSFEAGRRCMSGPGIYTFRVH 95
            |:.|:|....:||...|..||...||:: |....|||||.:..:|||||||||.||||.:||:..
Mouse   172 GSYILRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTS 236

  Fly    96 NAEQLYPMFQRYINAVNTDAFVQGERERVNSAHSV---SVNMGRTEGNNYLEPAPLMSRQLGNFH 157
            ....::       .||......|..:.:|..|..:   ..:.|.|||.....|.|
Mouse   237 QGNDIF-------QAVEAAIQQQKAQGKVGQAQDILRTDSHDGETEGKTVPPPVP---------- 284

  Fly   158 SEPSSTSASYPLQANDSQVDDSPPNLQSPVLIPSAYLDQPLRALQDCCLEGTASDLLSTPPSGNR 222
                                      |.|:..|.|...:||             |.|..||..:
Mouse   285 --------------------------QDPLGSPPALYAEPL-------------DSLRIPPGPS- 309

  Fly   223 LTSRRRTMDLPPLESAPAPAPVLSPNDAVHMYANVEALIFDLNNERCYENVN----RLELPLLPR 283
                :.::...||.|.||.|     .:.||   :.:.|.:||     |.:|.    :.:|.....
Mouse   310 ----QDSVYSDPLGSTPAGA-----GEGVH---SKKPLYWDL-----YGHVQQQLLKTKLTDSKE 357

  Fly   284 EPISNQ----EPATPTSLAGSCGVNYIVLDLDQ-PRSPVGPAGSSKAINGFGSGLSLISTPA--- 340
            :||.::    .||.|..|          .||.| ||.........|.     .|..|...||
Mouse   358 DPIYDEPEGLAPAPPRGL----------YDLPQEPRDAWWCQARLKE-----EGYELPYNPATDD 407

  Fly   341 -AVTAPVTPEAGTTLDVPPPPMQTQSLNSISADTGDTQAKKVTECSGTQGYSTIDFIRTYALNKS 404
             ||..|.:|:       |.|..:.|.|  |..::|.|:.      ||::|:|: |......:.||
Mouse   408 YAVPPPRSPK-------PAPAPKPQGL--ILPESGTTRG------SGSKGFSS-DTALYSQVQKS 456

  Fly   405 ST 406
            .|
Mouse   457 GT 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13398	NP_001260252.1	PTB_FRS2	15..109	CDD:269913	31/77 (40%)
Dok1	NP_034200.4	PH	5..116	CDD:278594
		PH-like	6..119	CDD:302622
		PTB_DOK1_DOK2_DOK3	151..253	CDD:269914	33/87 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..328		22/117 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..373		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..482		22/77 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5513
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.820