Protein Alignment CG13398 and FRS2

DIOPT Version :9

• Sequence 1: NP_001260252.1
• Gene: CG13398 / 34169
• FlyBaseID: FBgn0032042
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_001036020.1
• Gene: FRS2 / 10818
• HGNCID: 16971
• Length: 508
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 121/529 - (22%)
• Similarity: 198/529 - (37%)
• Gaps: 132/529 - (24%)

  Fly     1 MG-CITSSSKLNELRGHENVFRVRVAHLQPTPGTPIIRSGYLELTPRELIFQSPGCEPIVWALQH 64
            || |.:...|......|.|.|:|    :........:.||.:|||..|||..:...:.:.|....
Human     1 MGSCCSCPDKDTVPDNHRNKFKV----INVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLC 61

  Fly    65 LRRYGLNNDLFSFEAGRRCMSGPGIYTFRVHNAEQLYPMFQRYI--NAVN--------------- 112
            |||||.:::|||||:||||.:|.||:.|:...||:|:.|.|..:  |::|
Human    62 LRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTE 126

  Fly   113 -----------TDAFVQ-------------GERERVNSAHSVSVNMGR--TEGNNYLEPAPLMSR 151
                       |..|..             |:.....|:...||...|  :.|.....|..:...
Human   127 LEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEE 191

  Fly   152 QLGNF-------HSEPSSTSASYPLQANDSQVDDSPPNLQSPVLIPSAYLDQPLRALQDCCLEGT 209
            |:..:       ....:.||...||:|..|..:.|.|..:     ||:..|:..:.|.:  .||.
Human   192 QVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEE-----PSSIEDRDPQILLE--PEGV 249

  Fly   210 ASDLLSTPPSGNRLTSRRRTMDLPPLESAPAPAPVLSPNDAVHM-----YANVEALIFDLNNERC 269
            ...|..||       .:::.|:...||......  :|.:.|.:.     |.:.|.......|:..
Human   250 KFVLGPTP-------VQKQLMEKEKLEQLGRDQ--VSGSGANNTEWDTGYDSDERRDAPSVNKLV 305

  Fly   270 YENVNRLELPL---LPREPISNQEPATPTSLAGSCGVNYIVLDLDQ-PRSP-------------- 316
            |||:|.|.:|.   :.|..:::...:...::..|......:|:.:. |..|
Human   306 YENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDD 370

  Fly   317 -VGPAGSSKAINGFGSGL----SLISTPAAVTAPV-------------TPEAGTTLDVPPPPMQT 363
             :||  .:.::||:.:.|    :.::| ..||.|.             ||.. ...|:..|.::.
Human   371 NLGP--KTPSLNGYHNNLDPMHNYVNT-ENVTVPASAHKIEYSRRRDCTPTV-FNFDIRRPSLEH 431

  Fly   364 QSLNSI------SADTGDTQAKKV-------TECSGTQGYSTIDFIRTYALNKSSTELPE---TV 412
            :.||.|      .:|:.:.|..|.       |....|:.|:.||..||.|::.....||.   |.
Human   432 RQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTS 496

  Fly   413 THRQHSSHD 421
            ...:|:|.|
Human   497 RKTRHNSTD 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13398	NP_001260252.1	PTB_FRS2	15..109	CDD:269913	36/95 (38%)
FRS2	NP_001036020.1	PTB_FRS2	15..106	CDD:269913	36/94 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	122..180		7/57 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..243		11/47 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..297		4/28 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..338		2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	366..385		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..467		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	483..508		6/23 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141616
Domainoid	1	1.000	68	1.000	Domainoid score	I9723
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223604at33208
OrthoFinder	1	1.000	-	-		FOG0002576
OrthoInspector	1	1.000	-	-		otm41124
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21258
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5006
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.940