DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment emb and Xpo1

DIOPT Version :9

Sequence 1:	NP_001303316.1	Gene:	emb / 34167	FlyBaseID:	FBgn0020497	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_445942.1	Gene:	Xpo1 / 85252	RGDID:	620517	Length:	1071	Species:	Rattus norvegicus

Alignment Length:	1067	Identity:	759/1067 - (71%)
Similarity:	888/1067 - (83%)	Gaps:	8/1067 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TMLTSDEAGKLLDFSQKLDINLLDKIVEVVYTAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYS 67
            |||....|.:||||||||||||||.:|..:|..:|.|.|:||.:||.|||||:||||||:|||:|
  Rat     6 TMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFS 70

  Fly    68 QNQRTKFYALQILEEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKLNMILV 132
            ||..||:|.|||||.|||||||:||||||||||||||.|||||||||..:|:.|||:.|||||||
  Rat    71 QNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILV 135

  Fly   133 HILKREWPRNWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCS 197
            .|||:|||::|.||||||||||:|:||||.|||||||.|||||||||.|||||.|||||||:||:
  Rat   136 QILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKAKHLKDSMCN 200

  Fly   198 EFSQIFTLCSFVLENSMNAALIHVTLETLLRFLNWIPLGYIFETQQIETLIFKFLSVPMFRNVTL 262
            ||||||.||.||:|||.||.|:|.||||||||||||||||||||:.|.|||:|||:|||||||:|
  Rat   201 EFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSL 265

  Fly   263 KCLSEIAGLTAANYDENFATLFKDTMVQLEQIVGQNMNMNHVFKHGSDTEQELVLNLAMFLCTFL 327
            |||:||||::.:.|:|.|.|||..||:||:|::..|.|:...:.:|.|.||..:.||::||||||
  Rat   266 KCLTEIAGVSVSQYEEQFETLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFL 330

  Fly   328 KEHGKLVEDAKYV-DYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNSEFF----HPTLE 387
            ||||:|:|....: :.|.:||.|::::||||:.|:|||||||||.|..:||....|    .|.|.
  Rat   331 KEHGQLLEKRLNLREALMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLS 395

  Fly   388 STKRQQVYPRRRFYAPILSKVRFIMISRMAKPEEVLVVENENGEVVREFMKDTNSINLYKNMRET 452
            .::...:.|||:.|..:|||||.:|:||||||||||||||:.|||||||||||:|||||||||||
  Rat   396 GSQHFDIPPRRQLYLTVLSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRET 460

  Fly   453 LVFLTHLDSVDTDRIMTLKLLNQVNGSEFSWKNLNTLCWAIGSISGAFCEEDEKRFLVTVIKDLL 517
            ||:|||||.|||:.|||.||.|||||:|:||||||||||||||||||..||||||||||||||||
  Rat   461 LVYLTHLDYVDTEIIMTKKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLL 525

  Fly   518 GLCEQKKGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIK 582
            ||||||:||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
  Rat   526 GLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIK 590

  Fly   583 IAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMISAQVDQVQQDVLIE 647
            ||.||||:||.:|..|...||||||..:::|||||||||||||||||||||.||.||..|:.|||
  Rat   591 IAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIE 655

  Fly   648 RYMQLPNQVWDDIISRASKNVDFLKNMTAVKQLGSILKTNVAACKALGHAYVIQLGRIYLDMLNV 712
            :||.|||||||.||.:|:||||.||:...||||||||||||.||||:||.:||||||||||||||
  Rat   656 KYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNV 720

  Fly   713 YKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNLISEWVSRSNDNQLVMDNFIPPLLDAIL 777
            ||..||||..||:.||..|..||||::|..||:|||.|||.|||||||.|:|.:||:||||||:|
  Rat   721 YKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVL 785

  Fly   778 LDYQRCKVPSAREPKVLSAMAIIVHKLRQHITNEVPKIFDAVFECTLDMINKNFEDFPQHRLSFY 842
            :|||| .||:||||:|||.|||||:||..|||.|:|:||||||||||:||||:||::|:||.:|:
  Rat   786 IDYQR-NVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFF 849

  Fly   843 ELLQAVNAHCFKAFLNIPPAQFKLVFDSVVWAFKHTMRNVADMGLNILFKMLQNLDQHPGAAQSF 907
            .||||||:|||.|||.|||||||||.||::||||||||||||.||.|||.:|||:.|...|||||
  Rat   850 LLLQAVNSHCFPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSF 914

  Fly   908 YQTYFTDILMQIFSVVTDTSHTAGLPNHAIILAYMFSLVENRKITVNLGP-IP-DNMIFIQEYVA 970
            |||||.|||..||||||||||||||..||.||||||:|||..||:..|.| .| .|.:|||:|||
  Rat   915 YQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTPLNPGSPVSNQMFIQDYVA 979

  Fly   971 SLLKSAFTHLSDNQVKVFVTGLFNLDENVQAFKEHLRDFLIQIREATGEDDSDLYLEEREAALAE 1035
            :||||||.||.|.|||:||||||:|::::.||||||||||:||:|..|||.|||:|||||.||.:
  Rat   980 NLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEERETALRQ 1044

  Fly  1036 EQSNKHQMQRNIPGMLNPHELPEDMQD 1062
            .|..||::|.::||:|||||:||:|.|
  Rat  1045 AQEEKHKLQMSVPGILNPHEIPEEMCD 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_001303316.1	CRM1	13..1023	CDD:227432	730/1016 (72%)
		IBN_N	43..109	CDD:197981	52/65 (80%)
		Xpo1	120..265	CDD:285575	115/144 (80%)
		CRM1_C	701..1015	CDD:285920	224/315 (71%)
Xpo1	NP_445942.1	CRM1	15..1044	CDD:227432	740/1029 (72%)
		HEAT 1	217..240		18/22 (82%)
		HEAT 2	241..277		26/35 (74%)
		Necessary for interaction with Ran and nuclear export complex formation. /evidence=ECO:0000250	327..450		69/122 (57%)
		HEAT 3	354..472		74/117 (63%)
		Necessary for interaction with RANBP3. /evidence=ECO:0000250	411..481		56/69 (81%)
		HEAT 4	515..553		35/37 (95%)
		HEAT 5	560..597		35/36 (97%)
		HEAT 6	602..639		25/36 (69%)
		HEAT 7	775..813		29/38 (76%)
		HEAT 8	885..916		21/30 (70%)
		HEAT 9	917..954		29/36 (81%)
		HEAT 10	1002..1039		24/36 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339144
Domainoid	1	1.000	443	1.000	Domainoid score	I512
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2554
Inparanoid	1	1.050	1518	1.000	Inparanoid score	I90
OMA	1	1.010	-	-		QHG53807
OrthoDB	1	1.010	-	-		D132850at2759
OrthoFinder	1	1.000	-	-		FOG0003578
OrthoInspector	1	1.000	-	-		oto98181
orthoMCL	1	0.900	-	-		OOG6_101697
Panther	1	1.100	-	-	LDO	PTHR11223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2450
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770