DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment emb and Xpo6

DIOPT Version :9

Sequence 1:	NP_001303316.1	Gene:	emb / 34167	FlyBaseID:	FBgn0020497	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	XP_017167830.1	Gene:	Xpo6 / 74204	MGIID:	2429950	Length:	1140	Species:	Mus musculus

Alignment Length:	1324	Identity:	246/1324 - (18%)
Similarity:	435/1324 - (32%)	Gaps:	481/1324 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SQKLDINLLDKIVEVVY--TAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYSQNQRTKFYALQI 79
            |::..:..|:.::...:  ....|:.|..:.:|....:...||......|..::|.....|:|.:
Mouse     3 SEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQVGAWRFCLYFLSSTRNDYVMMYSLTV 67

  Fly    80 LEEVIKTRWKVLPRNQCEGIKKYVVSLII---KTSSDPIVMEQNKVYLNKLNMILVHILKREWPR 141
            .|.:|...|..:|......|:..:..|::   ||.  |..:.      |||..::|.|.:::||.
Mouse    68 FENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTL--PYFIR------NKLCKVIVDIGRQDWPM 124

  Fly   142 NWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCSEFSQIFTLC 206
            .:..|.::|:...::..:..: .:::||..|||: ...:..::..:.:.|:..:..:...:..|.
Mouse   125 FYHDFFTNILQLIQSPVTTPL-GLIMLKTTSEEL-ACPREDLSVARKEELRKLLLDQVQTVLGLL 187

  Fly   207 SFVLE-----NSMNAA--------------------------LIH---------------VTLET 225
            :.:||     :|:.||                          |:|               :.||.
Mouse   188 TGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLHQPIPILDVESEYVCSLALEC 252

  Fly   226 LLRFLNWIPLGYIFETQQIETLIFKF------------------------------LSVPMFRNV 260
            |....:||||.... |..:.|.||.|                              |.|     :
Mouse   253 LAHLFSWIPLSASI-TPSLLTTIFHFARFGCDTRARKMASVNGSSQNCVLGQERGRLGV-----L 311

  Fly   261 TLKCLSEIAGLTAA--NYDENFATLFKDTMVQLEQIVGQNMNMNHVFKH---------GSDTEQE 314
            .:.|::|:......  .::|....:|:.|...|::|...  |..|..|.         ||:.:.|
Mouse   312 AMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKD--NNAHTVKSRLEELDESPGSEVKAE 374

  Fly   315 LVLNLAMFLCTFLKEHGKLVEDAKYVDYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNS 379
            ..|....::             .|:.|:|.  |...|.:..:|....|.: :|:    :..|:..
Mouse   375 RCLEAESYI-------------EKFTDFLR--LFVSVHLRRIESYSQFPV-VEF----LTLLFKY 419

  Fly   380 EFFHPTLES--------TKRQQVYPRRRFYAPILSKVRFIMISRMAKPEEV----------LVVE 426
            .|..||.|.        |         .|...:.||::    ||:...|.|          |:.|
Mouse   420 TFHQPTHEGYFSCLDIWT---------LFLDYLTSKIK----SRLGDKEAVLNRYEDALVLLLTE 471

  Fly   427 NEN-----------GEVVREFMKDTNSINLYKNMRETL-VFLTHLDSVDTDRIMTLKLLNQVN-- 477
            ..|           .|:..|.:.|.......:.:|::| |....::.:.|....||..:.|.|
Mouse   472 VLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLE 536

  Fly   478 ------------GS---------------EFSWKNLNTLCWAIGSISGAFC-EEDEKRF--LVTV 512
                        ||               ..|.::|::|..|:|.::..|. :....||  .:||
Mouse   537 VYLGLQQFVVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTV 601

  Fly   513 IKDLLGLCEQKKGKDNK---------AIIASNIMYVVGQYPRFLRA--HWKFLKTVVNKLFEFMH 566
            ::.|:.:  ...|...|         :::..:::.|..|....|:|  ||         |.::..
Mouse   602 VERLVKV--TLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHW---------LAQYCG 655

  Fly   567 ETHDGVQDMACDTFIKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGY 631
            |.|.               :..:.|||:           |.|||                :|:..
Mouse   656 EAHR---------------QNTQQFVTL-----------ISTTM----------------DAITP 678

  Fly   632 MISAQVDQVQQDVLIERYMQLPNQVWDDIISRASK-NVDFLKNMTAV-KQLGSIL---------K 685
            :||.:|    ||.|:.....|       ::|.|:. ...||.::.|| |...||:         |
Mouse   679 LISTKV----QDKLLLSACHL-------LVSLATTVRPVFLISIPAVQKVFNSIIDASAQRLTDK 732

  Fly   686 TNVAACKALGHAYVIQLGRIYLDMLNVYKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNL 750
            ..|..|:||                                     :|..|:...::.:.|
Mouse   733 AQVLVCRAL-------------------------------------SNTLLLPWPNLPESE---- 756

  Fly   751 ISEWVSRSNDNQLVMDNFIPPLLDAILLDYQRCKVPSAREP--KV-LSAMAIIVHK-------LR 805
             .:|..||.::        ..|:.|:..||...| |||..|  || |....:|:|:       :.
Mouse   757 -QQWPLRSINH--------ASLISALSRDYHSLK-PSATAPQRKVPLGDTKVIIHQTLSVLEDIV 811

  Fly   806 QHITNEVPKIFDAVFECTLDMINKNFEDFP---------QHRLSFYELLQAVNAHCFKAF---LN 858
            ::|:.|..|.....::...:.:..:...||         ...|||:..|       |:..   :.
Mouse   812 ENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTL-------FRGLRVQMG 869

  Fly   859 IPPAQFKLVFDSVVWAFKH--TMRNVAD-------MGLNIL---FKMLQNLDQHPG--------- 902
            :|      ..:.::..|.:  |...:|:       .|..::   .|:||.:.|.||
Mouse   870 VP------FTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPS 928

  Fly   903 -AAQSFYQTY-------FTDILMQIFSVVTDTSH---------------TAGLPNH--------- 935
             .|....|.|       ..|:..::|.::..|.|               ..|:...
Mouse   929 IIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFS 993

  Fly   936 AIILAYMFSLVENRKITVNLGPIPDNMIFIQE--YVASL-LKSAFTHLSDNQVKVF-VTGLF--- 993
            ||:.|:..|.::           ||..:|.|.  |:.:| .|....|     .|:| .|.||
Mouse   994 AIMQAFGQSFLQ-----------PDIHLFKQNLFYLETLNTKQKLYH-----KKIFRTTMLFQFV 1042

  Fly   994 NLDENVQAFKEHLRDFL-----IQIREATGEDDSDLYLEEREAALAEE-----------QSN--- 1039
            |:...|...|.|  |.|     |.|......|....:     ||...|           |.|
Mouse  1043 NVLLQVLVHKSH--DLLQEEIGIAIYNMASVDFDGFF-----AAFLPEFLTSCDGVDANQKNVLG 1100

  Fly  1040 -KHQMQRNIPGML-NPHELPEDMQ 1061
             ..:|.|::|... |.|.|..|::
Mouse  1101 RNFKMDRDLPSFTQNVHRLVNDLR 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_001303316.1	CRM1	13..1023	CDD:227432	234/1268 (18%)
		IBN_N	43..109	CDD:197981	13/68 (19%)
		Xpo1	120..265	CDD:285575	37/220 (17%)
		CRM1_C	701..1015	CDD:285920	74/400 (19%)
Xpo6	XP_017167830.1	IBN_N	31..96	CDD:197981	13/64 (20%)
Xpo6	XP_017167830.1	Xpo1	103..277	CDD:369848	35/182 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900