DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment emb and XPO5

DIOPT Version :9

Sequence 1:NP_001303316.1 Gene:emb / 34167 FlyBaseID:FBgn0020497 Length:1063 Species:Drosophila melanogaster
Sequence 2:NP_065801.1 Gene:XPO5 / 57510 HGNCID:17675 Length:1204 Species:Homo sapiens


Alignment Length:1129 Identity:225/1129 - (19%)
Similarity:395/1129 - (34%) Gaps:328/1129 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ILEYSQNQRTKFYALQILEEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKL 127
            :.|.:|....:.:.|||||.|:|.||..:.|.:...:|..|:.||...:.: |:.|:|.: .:.|
Human    54 LAEKTQVAIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANGTLN-ILEEENHI-KDAL 116

  Fly   128 NMILVHILKREWPRNWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLK 192
            :.|:|.::|||||::|...:.::...||..|:.....|.||..|:|:|..|.  .:...:.:.::
Human   117 SRIVVEMIKREWPQHWPDMLIELDTLSKQGETQTELVMFILLRLAEDVVTFQ--TLPPQRRRDIQ 179

  Fly   193 DTMCSEFSQIFTLCSFVLENSMNAALIHVTLETLLRFLNWIPLGYIFETQQIETLIFKFLSVPMF 257
            .|:.....:||:.....|:.::|                        :.||::|      .....
Human   180 QTLTQNMERIFSFLLNTLQENVN------------------------KYQQVKT------DTSQE 214

  Fly   258 RNVTLKCLSEIAGL-TAANYDENFATLFKDTMVQLEQIVGQNMNMNHVFKHGSDTEQELVLNLAM 321
            ......|...:|.| |.|.|.:         .|.:..|..:|..:..:.....: ||||.|..|.
Human   215 SKAQANCRVGVAALNTLAGYID---------WVSMSHITAENCKLLEILCLLLN-EQELQLGAAE 269

  Fly   322 FLCTFLKEHGKLVEDAK--YVDYLNQALMYLVMISEVED----VE---VF-------------KI 364
            .|...:...||| ||.|  .|.:.:.|:.|::..::..|    ||   ||             ::
Human   270 CLLIAVSRKGKL-EDRKPLMVLFGDVAMHYILSAAQTADGGGLVEKHYVFLKRLCQVLCALGNQL 333

  Fly   365 CL---------------EYWNS-LVEDLYNSEFFHPTLEST----KRQQVYPRRRFYAPILSKVR 409
            |.               :|..| |....:.|:|...:.:.|    .|.::..|......|:.|..
Human   334 CALLGADSDVETPSNFGKYLESFLAFTTHPSQFLRSSTQMTWGALFRHEILSRDPLLLAIIPKYL 398

  Fly   410 FIMISRMAKPEEVLVVENENGEVVR-EFMKDTNSINLYKNMR----ETLVFLTHLDSVDTDRIMT 469
            ...::.:.|.......::.:.|..| :|..|.:....:.:.|    |.:.....||.        
Human   399 RASMTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQQGEVMRLACRLDP-------- 455

  Fly   470 LKLLNQVNGSEFSWKNLNTL--------CWAIGSISGAFCE---------EDEKRFLVTVI---- 513
             |...|:.|....:: |:|.        |.|:|:..|:.|.         |....||.:||    
Human   456 -KTSFQMAGEWLKYQ-LSTFLDAGSVNSCSAVGTGEGSLCSVFSPSFVQWEAMTLFLESVITQMF 518

  Fly   514 ----------KDLLGLCEQKKGKDNK-AIIASNIMYVVGQYPRFLRAHWKFLKTVVNKL-----F 562
                      .|.:.|.:.....|.| .:|.|.::..|.....|:....:||..|.:||     |
Human   519 RTLNREEIPVNDGIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRPEFLPQVFSKLFSSVTF 583

  Fly   563 EFMHETH-------DGVQDMACDTFIKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICD---L 617
            |.:.|:.       ..|:..||.:.||:   ||.|...:.||     .|.:...:..::.:   |
Human   584 ETVEESKAPRTRAVRNVRRHACSSIIKM---CRDYPQLVLPN-----FDMLYNHVKQLLSNELLL 640

  Fly   618 QPQQVHTFYEAVGYMISAQVDQVQ-QDVLIERYMQLPNQVWDDIISRASKNVDFLKNMTAVKQLG 681
            ...:.....||: .:||.|....: |.|.:|..|.....:|   :|:     |..:.::.|....
Human   641 TQMEKCALMEAL-VLISNQFKNYERQKVFLEELMAPVASIW---LSQ-----DMHRVLSDVDAFI 696

  Fly   682 SILKTNVAACKALGHAYVIQLGRIYLDMLNVYKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKE 746
            :.:.|:..:|.. |......|.|..:... ||.|                        :.|||:.
Human   697 AYVGTDQKSCDP-GLEDPCGLNRARMSFC-VYSI------------------------LGVVKRT 735

  Fly   747 TLNLISEWVSRSNDNQLVMDNFIPPLLDAILLDYQRCKVPSAREP---KVLSAMAIIVHKLRQHI 808
            .      |.:...:.:          ....::.|.....|..|.|   ::|..:..::..:|.|.
Human   736 C------WPTDLEEAK----------AGGFVVGYTSSGNPIFRNPCTEQILKLLDNLLALIRTHN 784

  Fly   809 TNEVPKIFDAVFECTLDMINKNFEDFPQHRLSFYELLQAVNAHCFKAFLNIPPAQFKL----VFD 869
            |...|           :|:.|..|.|.:    ..::|.|..:    |.|.:|....:|    ||.
Human   785 TLYAP-----------EMLAKMAEPFTK----ALDMLDAEKS----AILGLPQPLLELNDSPVFK 830

  Fly   870 SVVWAFKHTMRNVADMGLNILFKMLQNLDQHPGAAQSFYQTYFT--DILMQIFSVVTDTSHTAGL 932
            :|:...:.....:.:...:||.|          |..|..|.::|  |:..|:.|           
Human   831 TVLERMQRFFSTLYENCFHILGK----------AGPSMQQDFYTVEDLATQLLS----------- 874

  Fly   933 PNHAIILAYMFSLVENRKITVNLGPIPDN------MIFI------------QEYVASLLKSAFTH 979
                             ...|||..|||.      .:|:            :..|:.:|...||:
Human   875 -----------------SAFVNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLFTY 922

  Fly   980 LS---------DNQVKVFVTGLFNLDENVQAFKEHLRDFLIQI--RE------------------ 1015
            |.         .||..:........|||.:: :|.|.:.|:::  ||                  
Human   923 LHMRLSQKWQVINQRSLLCGEDEAADENPES-QEMLEEQLVRMLTREVMDLITVCCVSKKGADHS 986

  Fly  1016 ----ATGEDDSDLYLEEREAALAE 1035
                |.|:|:..:..|...:|:||
Human   987 SAPPADGDDEEMMATEVTPSAMAE 1010

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
embNP_001303316.1 CRM1 13..1023 CDD:227432 221/1115 (20%)
IBN_N 43..109 CDD:197981 16/45 (36%)
Xpo1 120..265 CDD:285575 28/144 (19%)
CRM1_C 701..1015 CDD:285920 61/351 (17%)
XPO5NP_065801.1 Necessary for interaction with Ran 2..108 17/54 (31%)
CRM1 64..>353 CDD:227432 75/333 (23%)
Xpo1 109..248 CDD:400614 36/180 (20%)
Necessary for interaction with ILF3 533..640 26/114 (23%)